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Chemical Biology in Zebrafish: Drug-Leads and New Targets in the Melanocyte Lineage and Melanoma


Mosaic RAS/MAPK variants cause sporadic vascular malformations which respond to targeted therapy

Author(s): Lara Al-Olabi, Satyamaanasa Polubothu, Katherine Dowsett, Katrina A. Andrews, Paulina Stadnik, Agnel P. Joseph, Rachel Knox, Alan Pittman, Graeme Clark, William Baird, Neil Bulstrode, Mary Glover, Kristiana Gordon, Darren Hargrave, Susan M. Huson, Thomas S. Jacques, Gregory James, Hannah Kondolf, Loshan Kangesu, Kim M. Keppler-Noreuil, Amjad Khan, Marjorie J. Lindhurst, Mark Lipson, Sahar Mansour,
Published in: Journal of Clinical Investigation, Issue 128/4, 2018, Page(s) 1496-1508, ISSN 0021-9738
DOI: 10.1172/JCI98589

Wilms Tumor 1b defines a wound-specific sheath cell subpopulation associated with notochord repair

Author(s): Juan Carlos Lopez-Baez, Daniel J Simpson, Laura LLeras Forero, Zhiqiang Zeng, Hannah Brunsdon, Angela Salzano, Alessandro Brombin, Cameron Wyatt, Witold Rybski, Leonie F A Huitema, Rodney M Dale, Koichi Kawakami, Christoph Englert, Tamir Chandra, Stefan Schulte-Merker, Nicholas D Hastie, E Elizabeth Patton
Published in: eLife, Issue 7, 2018, ISSN 2050-084X
DOI: 10.7554/eLife.30657

Location, Location, Location: Spatio-Temporal Cues That Define the Cell of Origin in Melanoma

Author(s): Maria S. Soengas, E. Elizabeth Patton
Published in: Cell Stem Cell, Issue 21/5, 2017, Page(s) 559-561, ISSN 1934-5909
DOI: 10.1016/j.stem.2017.10.009

Cell signalling: Red alert about lipid's role in skin cancer

Author(s): Ian J. Jackson, E. Elizabeth Patton
Published in: Nature, Issue 549/7672, 2017, Page(s) 337-339, ISSN 0028-0836
DOI: 10.1038/nature23550

Loss of the chromatin modifier Kdm2aa causes BrafV600E-independent spontaneous melanoma in zebrafish

Author(s): Catherine M. Scahill, Zsofia Digby, Ian M. Sealy, Sonia Wojciechowska, Richard J. White, John E. Collins, Derek L. Stemple, Till Bartke, Marie E. Mathers, E. Elizabeth Patton, Elisabeth M. Busch-Nentwich
Published in: PLOS Genetics, Issue 13/8, 2017, Page(s) e1006959, ISSN 1553-7404
DOI: 10.1371/journal.pgen.1006959

Fish from Head to Tail: The 9th European Zebrafish Meeting in Oslo

Author(s): Gareth Griffiths, Ferenc Müller, Johan Ledin, E. Elizabeth Patton, Tor Gjøen, Viola Hélène Lobert, Hanne Cecilie Winther-Larsen, Mary Mullins, Jean-Stephane Joly, Finn-Arne Weltzien, Charles McLean Press, Peter Aleström
Published in: Zebrafish, Issue 13/2, 2016, Page(s) 132-137, ISSN 1545-8547
DOI: 10.1089/zeb.2015.1212

ALDH1 Bio-activates Nifuroxazide to Eradicate ALDHHigh Melanoma-Initiating Cells

Author(s): Sana Sarvi, Richard Crispin, Yuting Lu, Lifan Zeng, Thomas D. Hurley, Douglas R. Houston, Alex von Kriegsheim, Che-Hong Chen, Daria Mochly-Rosen, Marco Ranzani, Marie E. Mathers, Xiaowei Xu, Wei Xu, David J. Adams, Neil O. Carragher, Mayumi Fujita, Lynn Schuchter, Asier Unciti-Broceta, Valerie G. Brunton, E. Elizabeth Patton
Published in: Cell Chemical Biology, 2018, ISSN 2451-9456
DOI: 10.1016/j.chembiol.2018.09.005

Assessment of biocompatibility of 3D printed photopolymers using zebrafish embryo toxicity assays

Author(s): N. P. Macdonald, F. Zhu, C. J. Hall, J. Reboud, P. S. Crosier, E. E. Patton, D. Wlodkowic, J. M. Cooper
Published in: Lab Chip, Issue 16/2, 2016, Page(s) 291-297, ISSN 1473-0197
DOI: 10.1039/C5LC01374G

Cross-species models of human melanoma

Published in: ISSN 0022-3417
DOI: 10.1002/path.4632

Rapid Discovery and Structure–Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase

Author(s): Craig Fraser, John C. Dawson, Reece Dowling, Douglas R. Houston, Jason T. Weiss, Alison F. Munro, Morwenna Muir, Lea Harrington, Scott P. Webster, Margaret C. Frame, Valerie G. Brunton, E. Elizabeth Patton, Neil O. Carragher, Asier Unciti-Broceta
Published in: Journal of Medicinal Chemistry, Issue 59/10, 2016, Page(s) 4697-4710, ISSN 0022-2623
DOI: 10.1021/acs.jmedchem.6b00065

Generation and analysis of zebrafish melanoma models

Author(s): S. Wojciechowska, E. van Rooijen, C. Ceol, E.E. Patton, R.M. White
Published in: Methods Cell Biol., 2016, Page(s) 531-549, ISSN 0091-679X
DOI: 10.1016/bs.mcb.2016.03.008

Let's make it happen: for gender equality in science!

Published in: ISSN 1755-1471
DOI: 10.1111/pcmr.12421

Melanoma Regression and Recurrence in Zebrafish

Author(s): Sonia Wojciechowska, Zhiqiang Zeng, James A. Lister, Craig J. Ceol, E. Elizabeth Patton
Published in: Methods Mol Biol., 2016, Page(s) 143-153, ISSN 1940-6029
DOI: 10.1007/978-1-4939-3771-4_10

Zebrafish MITF-Low Melanoma Subtype Models Reveal Transcriptional Subclusters and MITF-Independent Residual Disease

Author(s): Jana Travnickova, Sonia Wojciechowska, Ava Khamseh, Philippe Gautier, Daniel V. Brown, Thomas Lefevre, Alessandro Brombin, Ailith Ewing, Amy Capper, Michaela Spitzer, Ramile Dilshat, Colin A. Semple, Marie E. Mathers, James A. Lister, Eiríkur Steingrimsson, Thierry Voet, Chris P. Ponting, E. Elizabeth Patton
Published in: Cancer Research, Issue 79/22, 2019, Page(s) 5769-5784, ISSN 0008-5472
DOI: 10.1158/0008-5472.can-19-0037

Fishing for ancestry

Author(s): Hannah Brunsdon, E Elizabeth Patton
Published in: eLife, Issue 7, 2018, ISSN 2050-084X
DOI: 10.7554/elife.39524

Endothelin receptor Aa regulates proliferation and differentiation of Erb-dependent pigment progenitors in zebrafish

Author(s): Karen Camargo-Sosa, Sarah Colanesi, Jeanette Müller, Stefan Schulte-Merker, Derek Stemple, E. Elizabeth Patton, Robert N. Kelsh
Published in: PLOS Genetics, Issue 15/2, 2019, Page(s) e1007941, ISSN 1553-7404
DOI: 10.1371/journal.pgen.1007941

BRAF/MAPK and GSK3 signaling converges to control MITF nuclear export

Author(s): Kao Chin Ngeow, Hans J. Friedrichsen, Linxin Li, Zhiqiang Zeng, Sarah Andrews, Laurent Volpon, Hannah Brunsdon, Georgina Berridge, Sarah Picaud, Roman Fischer, Richard Lisle, Stefan Knapp, Panagis Filippakopoulos, Helen Knowles, Eiríkur Steingrímsson, Katherine L. B. Borden, E. Elizabeth Patton, Colin R. Goding
Published in: Proceedings of the National Academy of Sciences, Issue 115/37, 2018, Page(s) E8668-E8677, ISSN 0027-8424
DOI: 10.1073/pnas.1810498115

Bright insights into palladium-triggered local chemotherapy

Author(s): Thomas L. Bray, Mark Salji, Alessandro Brombin, Ana M. Pérez-López, Belén Rubio-Ruiz, Laura C. A. Galbraith, E. Elizabeth Patton, Hing Y. Leung, Asier Unciti-Broceta
Published in: Chemical Science, Issue 9/37, 2018, Page(s) 7354-7361, ISSN 2041-6520
DOI: 10.1039/c8sc02291g

Spotlight on zebrafish: the next wave of translational research

Published in: ISSN 1754-8403
DOI: 10.1242/dmm.039370

Notochord Injury Assays that Stimulate Transcriptional Responses in Zebrafish Larvae

Author(s): Zhiqiang Zeng, Juan Lopez-Baez, Laura Lleras-Forero, Hannah Brunsdon, Cameron Wyatt, Witold Rybski, Nicholas Hastie, Stefan Schulte-Merker, E Patton
Published in: BIO-PROTOCOL, Issue 8/23, 2018, ISSN 2331-8325
DOI: 10.21769/bioprotoc.3100

Supporting women in science at PCMR

Published in: ISSN 1755-1471
DOI: 10.1111/pcmr.12798