OlfSwitch: Neural circuit switches from molecules to behaviour

Project Information

OlfSwitch

Grant agreement ID: 649111

DOI

10.3030/649111

Project closed

EC signature date 23 June 2015

Start date 1 July 2015

End date 31 December 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 990 791,00

EU contribution

€ 1 990 791,00

Coordinated by

UNITED KINGDOM RESEARCH AND INNOVATION
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (20)

Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly

Author(s): Li, Hongjie; Janssens, Jasper; De Waegeneer, Maxime; Kolluru, Sai Saroja; Davie, Kristofer; Gardeux, Vincent; Saelens, Wouter; David, Fabrice P. A.; Brbić, Maria; Spanier, Katina; Leskovec, Jure; McLaughlin, Colleen N.; Xie, Qijing; Jones, Robert C.; Brueckner, Katja; Shim, Jiwon; Tattikota, Sudhir Gopal; Schnorrer, Frank; Rust, Katja; Nystul, Todd G.; Carvalho-Santos, Zita; Ribeiro, Carlos; Pal,
Published in: Science, Issue 375, 2022, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abk2432

BAcTrace a new tool for retrograde tracing of neuronal circuits

Author(s): Sebastian Cachero; Marina Gkantia; Alexander Shakeel Bates; Shahar Frechter; Laura Blackie; Laura Blackie; Amy McCarthy; Amy McCarthy; Ben Sutcliffe; Alessio Strano; Alessio Strano; Yoshinori Aso; Gregory S.X.E. Jefferis
Published in: Nature Methods, Issue 17, 2020, Page(s) 1254–1261, ISSN 1548-7091
Publisher: Nature Publishing Group
DOI: 10.1038/s41592-020-00989-1

Complete connectomic reconstruction of olfactory projection neurons in the fly brain

Author(s): Bates, A.S.; Schlegel, P.; Roberts, R.J.V.; Drummond, N.; Tamimi, I.F.M.; Turnbull, R.; Zhao, X.; Marin, E.C.; Popovici, P.D.; Dhawan, S.; Jamasb, A.; Javier, A.; Li, F.; Rubin, G.M.; Waddell, S.; Bock, D.D.; Costa, M.; Jefferis, G.S.X.E.
Published in: Current Biology, Issue 3, 2020, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1101/2020.01.19.911453

Olfactory Neurons and Brain Centers Directing Oviposition Decisions in Drosophila

Author(s): Sonia G. Chin; Sarah E. Maguire; Paavo Huoviala; Gregory S.X.E. Jefferis; Christopher Potter
Published in: Cell Reports, Vol 24, Iss 6, Pp 1667-1678 (2018), Issue 3, 2018, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2018.07.018

A Complete Electron Microscopy Volume of the Brain of Adult Drosophila melanogaster.

Author(s): Zhihao Zheng; J. Scott Lauritzen; Eric Perlman; Camenzind G. Robinson; Matthew Nichols; Daniel E. Milkie; O. N. Torrens; J.H. Price; Corey B. Fisher; Nadiya Sharifi; Steven A. Calle-Schuler; Lucia Kmecova; Iqbal J. Ali; Bill Karsh; Eric T. Trautman; John A. Bogovic; Philipp Hanslovsky; Gregory S.X.E. Jefferis; Michael Kazhdan; Khaled Khairy; Stephan Saalfeld; Richard D. Fetter; Davi D. Bock
Published in: Cell, Issue 174, 2018, Page(s) 730-743, ISSN 1097-4172
Publisher: Cell Press
DOI: 10.17863/cam.36240

A Neural Circuit Arbitrates between Persistence and Withdrawal in Hungry Drosophila

Author(s): Sayin, Sercan; De Backer, Jean-Francois; Siju, KP; Wosniack, Marina E; Lewis, Laurence P; Frisch, Lisa-Marie; Gansen, Benedikt; Schlegel, Philipp; Edmondson-Stait, Amelia; Sharifi, Nadiya; Fisher, Corey B; Calle-Schuler, Steven A; Lauritzen, J Scott; Bock, Davi D; Costa, Marta; Jefferis, Gregory; Gjorgjieva, Julijana; Grunwald Kadow, Ilona C
Published in: Neuron, Issue 3, 2019, Page(s) 432-435, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.17863/cam.48744

Optimization of fluorophores for chemical tagging and immunohistochemistry of Drosophila neurons.

Author(s): Meissner, Geoffrey W.; Grimm, Jonathan B.; Johnston, Rebecca M.; Sutcliffe, Ben; Ng, Julian; Jefferis, Gregory S. X. E.; Cachero, Sebastian; Lavis, Luke D.; Malkesman, Oz
Published in: PLoS ONE, Issue 1, 2018, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.17863/cam.38098

Neurogenetic dissection of the Drosophila lateral horn reveals major outputs, diverse behavioural functions, and interactions with the mushroom body.

Author(s): Michael-John Dolan; Shahar Frechter; Alexander Shakeel Bates; Chuntao Dan; Paavo Huoviala; Ruairí JV Roberts; Philipp Schlegel; Serene Dhawan; Remy Tabano; Heather Dionne; Christina Christoforou; Kari Close; Ben Sutcliffe; Bianca Giuliani; Feng Li; Marta Costa; Gudrun Ihrke; Geoffrey Wilson Meissner; Davi D Bock; Yoshinori Aso; Gerald M Rubin; Gregory SXE Jefferis
Published in: eLife, Issue 3, 2019, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.43079

Information flow, cell types and stereotypy in a full olfactory connectome.

Author(s): Philipp Schlegel; Philipp Schlegel; Alexander Shakeel Bates; Tomke Stürner; Sridhar R. Jagannathan; Nikolas Drummond; Joseph Hsu; Joseph Hsu; Laia Serratosa Capdevila; Alexandre Javier; Elizabeth C. Marin; Asa Barth-Maron; Imaan F.M. Tamimi; Feng Li; Gerald M. Rubin; Stephen M. Plaza; Marta Costa; Gregory S.X.E. Jefferis; Gregory S.X.E. Jefferis
Published in: eLife, Issue 3, 2021, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.66018

Facilitating Neuron-Specific Genetic Manipulations in Drosophila melanogaster Using a Split GAL4 Repressor

Author(s): Michael-John Dolan, Haojiang Luan, William C. Shropshire, Ben Sutcliffe, Benjamin Cocanougher, Robert L. Scott, Shahar Frechter, Marta Zlatic, Gregory S. X. E. Jefferis, Benjamin H. White
Published in: Genetics, Issue 206/2, 2017, Page(s) 775-784, ISSN 0016-6731
Publisher: Genetics Society of America
DOI: 10.1534/genetics.116.199687

Second-Generation Drosophila Chemical Tags: Sensitivity, Versatility, and Speed

Author(s): Ben Sutcliffe, Julian Ng, Thomas O. Auer, Mathias Pasche, Richard Benton, Gregory S. X. E. Jefferis, Sebastian Cachero
Published in: Genetics, Issue 205/4, 2017, Page(s) 1399-1408, ISSN 0016-6731
Publisher: Genetics Society of America
DOI: 10.1534/genetics.116.199281

Pheromone processing in Drosophila

Author(s): Johannes Kohl, Paavo Huoviala, Gregory SXE Jefferis
Published in: Current Opinion in Neurobiology, Issue 34, 2015, Page(s) 149-157, ISSN 0959-4388
Publisher: Elsevier BV
DOI: 10.1016/j.conb.2015.06.009

Automatic Segmentation of Drosophila Neural Compartments Using GAL4 Expression Data Reveals Novel Visual Pathways

Author(s): Karin Panser; Laszlo Tirian; Florian Schulze; Santiago Villalba; Gregory S.X.E. Jefferis; Katja Bühler; Andrew D. Straw
Published in: Current Biology, Issue 2, 2016, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2016.05.052

Genetically targeted 3D visualisation ofDrosophilaneurons under Electron Microscopy and X-Ray Microscopy using miniSOG

Author(s): Julian Ng; Alyssa Browning; Lorenz Lechner; Masako Terada; Gillian Howard; Gregory Jefferis
Published in: Scientific Reports, Issue 4, 2016, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1101/070755

NBLAST: Rapid, Sensitive Comparison of Neuronal Structure and Construction of Neuron Family Databases

Author(s): Marta Costa; James D. Manton; Aaron D. Ostrovsky; Steffen Prohaska; Gregory S.X.E. Jefferis
Published in: Neuron, Issue 3, 2016, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2016.06.012

Communication from Learned to Innate Olfactory Processing Centers Is Required for Memory Retrieval in Drosophila.

Author(s): Dolan, Michael-John; Belliart-Guérin, Ghislain; Bates, Alexander Shakeel; Frechter, Shahar; Lampin-Saint-Amaux, Aurélie; Aso, Yoshinori; Roberts, Ruairí JV; Schlegel, Philipp; Wong, Allan; Hammad, Adnan; Bock, Davi; Rubin, Gerald M; Preat, Thomas; Plaçais, Pierre-Yves; Jefferis, Gregory
Published in: Neuron, Issue 3, 2018, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.17863/cam.38132

The natverse, a versatile toolbox for combining and analysing neuroanatomical data.

Author(s): Alexander Shakeel Bates; James D. Manton; Sridhar R. Jagannathan; Marta Costa; Marta Costa; Philipp Schlegel; Philipp Schlegel; Torsten Rohlfing; Gregory S.X.E. Jefferis; Gregory S.X.E. Jefferis
Published in: eLife, Issue 5, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.17863/cam.54736

Neuronal cell types in the fly: single-cell anatomy meets single-cell genomics.

Author(s): Alexander Shakeel Bates; Janssens J; Gregory S.X.E. Jefferis; Gregory S.X.E. Jefferis; Stein Aerts
Published in: Current Opinion in Neurobiology, Issue 56, 2019, Page(s) 125-134, ISSN 0959-4388
Publisher: Elsevier BV
DOI: 10.1016/j.conb.2018.12.012

Functional and Anatomical Specificity in a Higher Olfactory Centre

Author(s): Shahar Frechter; Alexander Shakeel Bates; Sina Tootoonian; Sina Tootoonian; Michael-John Dolan; Michael-John Dolan; James D. Manton; Arian R. Jamasb; Johannes Kohl; Davi D. Bock; Gregory S.X.E. Jefferis; Gregory S.X.E. Jefferis
Published in: eLife, Issue 9, 2019, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.44590

Learning from connectomics on the fly

Author(s): Schlegel, Philipp; Costa, Marta; Jefferis, Gregory SXE
Published in: Current Opinion in Insect Science, Issue 1, 2017, ISSN 2214-5745
Publisher: Elsevier BV
DOI: 10.1016/j.cois.2017.09.011

Other (4)

Neurotransmitter Classification from Electron Microscopy Images at Synaptic Sites in Drosophila

Author(s): Nils Eckstein; Alexander Shakeel Bates; Michelle Du; Volker Hartenstein; Gregory S.X.E. Jefferis; Jan Funke
Published in: bioRxiv, 2020
Publisher: bioRxiv
DOI: 10.1101/2020.06.12.148775

Generating parallel representations of position and identity in the olfactory system

Author(s): Taisz, István; Donà, Erika; Münch, Daniel; Bailey, Shanice N.; Morris, Billy J.; Meechan, Kimberly I.; Stevens, Katie M.; Varela, Irene; Gkantia, Marina; Schlegel, Philipp; Ribeiro, Carlos; Jefferis, Gregory S.X.E.; Galili, Dana S.
Published in: bioRxiv, Issue 1, 2022
Publisher: bioRxiv
DOI: 10.1101/2022.05.13.491877

Automated Reconstruction of a Serial-Section EM Drosophila Brain with Flood-Filling Networks and Local Realignment

Author(s): Li, Peter H.; Lindsey, Larry F.; Januszewski, Michał; Zheng, Zhihao; Bates, Alexander Shakeel; Taisz, István; Tyka, Mike; Nichols, Matthew; Li, Feng; Perlman, Eric; Maitin-Shepard, Jeremy; Blakely, Tim; Leavitt, Laramie; Jefferis, Gregory S.X.E.; Bock, Davi; Jain, Viren
Published in: bioRxiv, Issue 1, 2019
Publisher: bioRxiv
DOI: 10.1101/605634

Neural circuit basis of aversive odour processing in Drosophila from sensory input to descending output.

Author(s): Paavo Huoviala; Michael-John Dolan; Fiona M. Love; Philip Myers; Shahar Frechter; Shigehiro Namiki; Lovisa Pettersson; Ruairí J.V. Roberts; Robert Turnbull; Zane Mitrevica; Patrick Breads; Philipp Schlegel; Alexander Shakeel Bates; Tiago Rodrigues; Yoshinori Aso; Davi Bock; Gerald M. Rubin; Marcus Stensmyr; Gwyneth Card; Marta Costa; Gregory S.X.E. Jefferis
Published in: bioRxiv, Issue 2, 2020, ISSN 2692-8205
Publisher: bioRxiv
DOI: 10.1101/394403