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Automated synthesis of S. pneumoniae 7F capsular polysaccharide repeating unit as candidate for conjugate vaccines


The goal of this project is to develop an automated synthesis of the Streptococcus pneumoniae 7F capsular polysaccharide repeating unit, which is of high interest for synthetic vaccines against this pathogen. This structural motif has never been synthesized yet, not even by traditional solution techniques. Our approach is highly innovative in the application of automated oligosaccharide synthesis, which will make the synthetic procedure more time- and cost-effective.
In the course of the project, a series of orthogonally protected monosaccharide building blocks will be synthesized. The oligosaccharide will be assembled on oligosaccharide synthesizer. Photocleavage in a flow reactor and global deprotection will yield the target molecule. The oligosaccharide will be subjected to bioconjugation with a CRM197 carrier protein to produce conjugate vaccine candidate. This conjugate will be tested for the ability to induce an immune response against S. penumoniae 7F.

Field of science

  • /medical and health sciences/health sciences/public and environmental health/epidemics prevention/immunisation
  • /natural sciences/biological sciences/molecular biology
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/pharmaceutical drug/vaccines
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins
  • /natural sciences/biological sciences/biochemistry/biomolecules/carbohydrates

Call for proposal

See other projects for this call

Funding Scheme

MSCA-IF-EF-ST - Standard EF


Hofgartenstrasse 8
80539 Muenchen
Activity type
Research Organisations
EU contribution
€ 159 460,80