Electrophile-Mediated Three-Component Enantiospecific Cross-Couplings

Project Information

EMTECS

Grant agreement ID: 652890

DOI 10.3030/652890

Project closed

EC signature date 25 March 2015

Start date 1 March 2015

End date 28 February 2017

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 195 454,80

EU contribution € 195 454,80

Coordinated by

UNIVERSITY OF BRISTOL
United Kingdom

Objective

One of the most challenging aspects of Suzuki-Miyaura reactions is the stereospecific cross-coupling of sp3 substituted boronic esters with aryl halides. Recently, the host group developed a metal-free, stereospecific cross-coupling reaction of chiral alkyl boronates with electron-rich aromatics, promoted by the use of electrophilic oxidants. This proposal seeks to substantially extend this cross-coupling chemistry through the application of a range of different electrophiles that will not only mediate the cross-coupling process, but also remain in the final product, creating multiple carbon–carbon bonds stereospecifically. In particular, the application of electrophilic organometallic species will be investigated so as to take advantage of the power of metal catalysts in the formation of carbon–carbon bonds. Through the use of this strategy, doubly functionalised enantiopure aromatic compounds may be formed in a very efficient three-component coupling process that utilises readily accessible enantiopure alkyl boronic esters, electron-rich aromatics and catalytically generated organometallic electrophiles.

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.

• medical and health sciences › basic medicine › pharmacology and pharmacy › drug discovery
• natural sciences › chemical sciences › electrochemistry › electrolysis
• natural sciences › chemical sciences › catalysis
• natural sciences › chemical sciences › organic chemistry › aromatic compounds
• natural sciences › chemical sciences › inorganic chemistry › metalloids

You need to log in or register to use this function

Programme(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

• MSCA-IF-2014-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF)

Call for proposal

H2020-MSCA-IF-2014

Funding Scheme

MSCA-IF-EF-ST - Standard EF

Coordinator

UNIVERSITY OF BRISTOL

• Net EU contribution: € 195 454,80
• Address: BEACON HOUSE QUEENS ROAD ; BS8 1QU Bristol ; United Kingdom
• Region: South West (England) › Gloucestershire, Wiltshire and Bristol/Bath area › Bristol, City of
• Activity type: Higher or Secondary Education Establishments
• Total cost: € 195 454,80