Objective
Recently, the discovery of new antibiotics has slowed, while the incidences of infections caused by bacteria that have become resistant to commonly used antibiotics are rising. There is therefore a growing clinical need for innovative approaches to developing novel anti-infective compounds. Hydrogen is an important energy substrate for a number of pathogenic bacteria and H2 oxidation is essential for the virulence of Salmonella enterica serovar Typhimurium. S. enterica expresses three different H2-uptake [NiFe]-hydrogenases and one of these (termed hydrogenase-5) belongs to a novel class of O2-tolerant hydrogenases that is synthesized aerobically and oxidizes H2 in the presence of O2. The Hyd-5 gene cluster encodes two accessory proteins, HydH and HydG, that are absent in anaerobic systems and are conserved in those systems in which hydrogenases are synthesized in the presence of oxygen. In other systems, HydH homologs have been proposed as scaffolding proteins that bind the immature [NiFe] cofactor prior its transfer to the large subunit of the enzyme. HydG-like proteins are hypothesised to assemble or stabilize the Fe-S clusters of small subunit during biosyntheis. This proposal aims to study the functional role of accessory proteins HydH and HydG in the biosynthesis of Hyd-5 and to design novel small molecule compounds that potentially inhibit hydrogenase activity and assembly. Understanding the mechanisms involved in the biosynthesis of Hyd-5 will allow the development of hydrogenase inhibitors and, as consequence, anti-infectives of virulence of Salmonella and other bacterial pathogens. This project addresses a key biomedical challenge and establishes [NiFe] hydrogenases as novel and credible drug targets.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology bacteriology
- natural sciences chemical sciences electrochemistry electrolysis
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antibiotics
- engineering and technology environmental engineering energy and fuels fuel cells
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2014
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
DD1 4HN Dundee
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.