European Nanomedicine Characterization Laboratory

Deliverables

Documents, reports (27)

Liaison activities with external stakeholders –final report

A final report on the Liaison activities with external stakeholders will be prepared.

1st scientific report on Structure Activity Relationship studies

2nd report on reviews of QMS of EU-NCL

2nd scientific report on mode of action studies

Liaison activities with external stakeholders – 1st report

2nd Prioritized list of candidate technologies

3rd report on reviews of QMS of EU-NCL

1st completed survey with regulatory bodies

Activities to promote innovation through partnership with industry– 3rd report

2nd Completed survey with regulatory bodies

1st report on reviews of QMS of EU-NCL

CMS implemented

1st Data management plan

1st List of candidate technologies

2nd Data management plan

2nd report on the testing and optimization of novel technologies

1st report on modeling of analytical decision process

3rd Completed survey with regulatory bodies

3rd Data Management Plan

3rd Sample Management Report

1st report on the testing and optimization of novel technologies

Activities to promote innovation through partnership with industry – 2nd report

Activities to promote innovation through partnership with industry– 2nd report

Activities to promote innovation through partnership with industry– 1st report

2nd List of candidate technologies

2nd scientific report on Structure Activity Relationship studies

1st Prioritized list of candidate technologies

1st scientific report on mode of action studies

2nd report on modeling of analytical decision process

Websites, patent fillings, videos etc. (9)

Publication of 2nd TNA open call

EU-NCL annual workshop –year 3

Publication of 1st TNA open call

Publication of “State-of-the-art” manuscript – version 1

EU-NCL annual workshop –year 2

Publication of “State-of-the-art” manuscript – version 2

EU-NCL annual workshop – year 4

EU-NCL website

Publication of 3rd TNA open call

Demonstrators, pilots, prototypes (5)

3rd Collection of approved measurement SOPs

2nd Collection of approved measurement SOPs

1st Collection of approved measurement SOPs

Sample receiving laboratory installed

4th Collection of approved measurement SOPs

Other (3)

TNA “guide for applicant” & evaluation form

CMS developed

Appointment of the peer review evaluation board

Publications

Peer reviewed articles (6)

Analytical ultracentrifugation for analysis of doxorubicin loaded liposomes

Author(s): Dora Mehn, Patrizia Iavicoli, Noelia Cabaleiro, Sven Even Borgos, Fanny Caputo, Otmar Geiss, Luigi Calzolai, François Rossi, Douglas Gilliland
Published in: International Journal of Pharmaceutics, 523/1, 2017, Page(s) 320-326, ISSN 0378-5173
Publisher: Elsevier BV
DOI: 10.1016/j.ijpharm.2017.03.046

Measuring Particle Size Distribution by Asymmetric Flow Field Flow Fractionation: A Powerful Method for the Preclinical Characterization of Lipid-Based Nanoparticles

Author(s): Fanny Caputo, Amandine Arnould, Maria Bacia, Wai Li Ling, Emilie Rustique, Isabelle Texier, Adriele Prina Mello, Anne-Claude Couffin
Published in: Molecular Pharmaceutics, 16/2, 2018, Page(s) 756-767, ISSN 1543-8384
Publisher: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.8b01033

Are existing standard methods suitable for the evaluation of nanomedicines: some case studies

Author(s): Sabrina Gioria, Fanny Caputo, Patricia Urbán, Ciarán Manus Maguire, Susanne Bremer-Hoffmann, Adriele Prina-Mello, Luigi Calzolai, Dora Mehn
Published in: Nanomedicine, 13/5, 2018, Page(s) 539-554, ISSN 1743-5889
Publisher: Future Medicine Ltd.
DOI: 10.2217/nnm-2017-0338

Larger or more? Nanoparticle characterisation methods for recognition of dimers

Author(s): D. Mehn, F. Caputo, M. Rösslein, L. Calzolai, F. Saint-Antonin, T. Courant, P. Wick, D. Gilliland
Published in: RSC Advances, 7/44, 2017, Page(s) 27747-27754, ISSN 2046-2069
Publisher: Royal Society of Chemistry
DOI: 10.1039/c7ra02432k

Measuring particle size distribution of nanoparticle enabled medicinal products, the joint view of EUNCL and NCI-NCL. A step by step approach combining orthogonal measurements with increasing complexity

Author(s): F. Caputo, J. Clogston, L. Calzolai, M. Rösslein, A. Prina-Mello
Published in: Journal of Controlled Release, 299, 2019, Page(s) 31-43, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2019.02.030

Sound understanding of environmental, health and safety, clinical, and market aspects is imperative to clinical translation of nanomedicines

Author(s): Matthias Rösslein, Neill J. Liptrott, Andrew Owen, Patrick Boisseau, Peter Wick, Inge K. Herrmann
Published in: Nanotoxicology, 11/2, 2017, Page(s) 147-149, ISSN 1743-5390
Publisher: Informa Healthcare
DOI: 10.1080/17435390.2017.1279361

Book chapters (1)

Multiparametric Preclinical Assessment of Theranostics Materials

Author(s): Adriele Prina-Mello
Published in: Handbook of Nanomaterials for Cancer Theranostics, 2018, Page(s) 517-535, ISBN 9780-128133392
Publisher: Elsevier
DOI: 10.1016/b978-0-12-813339-2.00017-7