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Unraveling the mechanobiology of tissue growth in native and tissue-engineered heart valves

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Publications

Growth and remodeling play opposing roles during postnatal human heart valve development

Author(s): Pim J. A. Oomen, Maria A. Holland, Carlijn V. C. Bouten, Ellen Kuhl, Sandra Loerakker
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
DOI: 10.1038/s41598-018-19777-1

Mechanosensitivity of Jagged–Notch signaling can induce a switch-type behavior in vascular homeostasis

Author(s): Sandra Loerakker, Oscar M. J. A. Stassen, Fleur M. ter Huurne, Marcelo Boareto, Carlijn V. C. Bouten, Cecilia M. Sahlgren
Published in: Proceedings of the National Academy of Sciences, Issue 115/16, 2018, Page(s) E3682-E3691, ISSN 0027-8424
DOI: 10.1073/pnas.1715277115

Predicting and understanding collagen remodeling in human native heart valves during early development

Author(s): T. Ristori, C.V.C. Bouten, F.P.T. Baaijens, S. Loerakker
Published in: Acta Biomaterialia, 2018, ISSN 1742-7061
DOI: 10.1016/j.actbio.2018.08.040

Age-dependent changes of stress and strain in the human heart valve and their relation with collagen remodeling

Author(s): P.J.A. Oomen, S. Loerakker, D. van Geemen, J. Neggers, M.-J.T.H. Goumans, A.J. van den Bogaerdt, A.J.J.C. Bogers, C.V.C. Bouten, F.P.T. Baaijens
Published in: Acta Biomaterialia, Issue 29, 2016, Page(s) 161-169, ISSN 1742-7061
DOI: 10.1016/j.actbio.2015.10.044