Understanding nervous mechanisms of cardioprotection to save the ischaemic and failing hearts

Project Information

RESCUE THE HEART

Grant agreement ID: 654691

DOI 10.3030/654691

Project closed

EC signature date 22 April 2015

Start date 1 April 2016

End date 31 March 2018

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 195 454,80

EU contribution € 195 454,80

Coordinated by

UNIVERSITY COLLEGE LONDON
United Kingdom

Objective

This project is designed to use the latest advances in molecular biology and neuroscience to determine the role played by the nervous mechanisms in the development of cardiovascular pathology. The project spans across distinct research fields of myocardial ischaemia/reperfusion injury, innate cardioprotective mechanisms and fundamental neuroscience and includes newly developed transgenic mice models and latest advances in viral gene transfer technology, pharmaco- and optogenetics for selective manipulation of parasympathetic or sympathetic efferent outflows to the heart. These novel genetic models offer unprecedented resolution and specificity and will be used to determine the role played by the autonomic nervous system in modulation of the myocardial ischaemia/reperfusion injury and progression of chronic heart failure. Another important part of this study will determine the involvement of neural pathways in powerful innate mechanisms of cardioprotection underlying the (pre)conditioning phenomena. The results of the proposed experiments are expected to have an instant translational potential and may lead to the development of novel therapeutic strategies which recruit innate neural mechanisms of cardioprotection to limit myocardial injury and improve quality of life of individuals suffering from heart disease. RESCUE THE HEART project includes an intense program of research and training to be undertaken by the experienced researcher and will ultimately promote effective transfer of research expertise, new technologies and research philosophy across wider European research base.

Fields of science

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.

• natural sciences › biological sciences › neurobiology
• medical and health sciences › clinical medicine › cardiology › cardiovascular diseases › cardiac arrhythmia
• medical and health sciences › medical biotechnology › genetic engineering › gene therapy
• medical and health sciences › basic medicine › pathology
• natural sciences › biological sciences › molecular biology

Programme(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

• MSCA-IF-2014-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF)

Call for proposal

H2020-MSCA-IF-2014

Funding Scheme

MSCA-IF-EF-ST - Standard EF

Coordinator

UNIVERSITY COLLEGE LONDON

• Net EU contribution: € 195 454,80
• Address: GOWER STREET ; WC1E 6BT London ; United Kingdom
• Region: London › Inner London — West › Camden and City of London
• Activity type: Higher or Secondary Education Establishments
• Total cost: € 195 454,80