Objective
Alterations in sleep/wakefulness behavior are among the most debilitating and highly prevalent non-motor symptoms of many neurological and psychiatric disorders that originate from perturbations of the Dopamine (DA) system. Currently, no effective therapeutic strategies are available to alleviate these symptoms. Inspired by my Ph.D results, the current proposal aims to investigate in detail the role of dopamine in the regulation of sleep and circadian rhythms. The main question under investigation is; By what mechanisms DA regulates sleep and circadian rhythms and how are these affected in diseases (such as Parkinson)? Two transgenic mouse models will be used; the first model (MitoPark) shows, like in Parkinson’s disease (PD) patients, a progressive age-dependent neurodegeneration of DA neurons. The second model (CircaDA) lacks functional clock gene oscillations selectively in DA neurons. Using polysomnography in MitoPark mice, a detailed investigation of the consequences of DA loss on sleep regulation will be performed. In-vivo multiunit electrophysiology will be used in both mouse models to study the role of the circadian changes in DA neurotransmission in driving and/or synchronizing the electrophysiological properties of striatal and cortical neurons. Finally, selective DA receptor drugs will be combined with in-vitro patch clamp electrophysiology and in-vitro Per2-bioluminescence to investigate the molecular pathways used by DA to modulate multiple electrophysiological correlates of clock gene oscillations. Collectively, this proposal holds promising fundamental and translational insights for sleep problems experienced by patients suffering from DA-related disorders and is expected to significantly contribute in fostering the academic career of the researcher and the competences of the hosting laboratory in Neurodegenerative diseases.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine psychiatry sleep disorders
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs
- medical and health sciences basic medicine pathology
- medical and health sciences basic medicine physiology
- medical and health sciences basic medicine neurology parkinson
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
See all projects funded under this programme -
H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2014
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
2333 ZA Leiden
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.