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Controlled Singlet Oxygen Release Photosensitizers in Photodynamic Therapy

Objective

Photodynamic therapy is a form of phototherapy which uses light-sensitive compounds (photosensitizers) that are exposed selectively to light, whereupon they become toxic to targeted malignant and other diseased cells. The photosensitizer creates a highly reactive singlet oxygen species which rapidly reacts with any nearby biomolecules leading to destructive reactions resulting in cell death through apoptosis or necrosis. However, prolonged exposure of tissue to light irradiation causes photosensitivity in patients’ skin. Side effects may include, pain, burning/stinging sensation, itchiness. This proposal aims to develop a conceptually new approach towards photodynamic therapy through an introduction of new type of photosensitizers and corresponding nanomaterials which are capable to generate singlet oxygen upon irradiation, store it by means of binding to special molecular subunits and slowly release singlet oxygen within tissue on a timescale from several hours to several days after light irradiation treatment. The application of such novel material will allow for increasing therapeutic effect and reduced side-effects with respect to conventional PDT due to shorter light treatment duration. Proof of concept will be attained by demonstration of delayed singlet oxygen formation in cancer cells after the light treatment using in vitro models. The project builds on the strengths of the applicant in organic chemistry, photophysics and material science and combines these with new training in biomedicine and drug development to open a new research direction and to enhance cross-European collaboration.

Field of science

  • /natural sciences/chemical sciences/organic chemistry
  • /medical and health sciences/clinical medicine/oncology/cancer
  • /natural sciences/biological sciences/biochemistry/biomolecules
  • /engineering and technology/nanotechnology/nano-materials

Call for proposal

H2020-MSCA-IF-2014
See other projects for this call

Funding Scheme

MSCA-IF-EF-ST - Standard EF

Coordinator

THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Address
College Green
2 Dublin
Ireland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 187 866