Objective The mechanisms underlying metabolic cost of walking are unclear. This is important not only because they provide fundamental insight in human movement, but they are also essential to reduce increased cost of walking in the elderly and impaired. To understand these mechanisms, it is required to know the link between energetics at the human level and the energetics at the muscle level. Whereas the energetics at the human level is experimentally accessible, that at the muscle level is not. Current estimations greatly overestimate actual metabolic cost and hence there is no basis understanding metabolic cost of walking. In this project I will first ever directly measure oxygen consumption of dynamically contracting muscle fibres. These experiments will be conceptually linked to in vivo experiments measuring oxygen consumption during isolated movements as well as during walking. Using these data and state-of-the art optimization techniques applied to detailed neuro-musculoskeletal models I will link energetics at the muscle level to that of a walking human and provide insight in the mechanisms underlying the metabolic cost of walking. This grant would allow the applicant to return fully to a EU research environment and would have a very significant and direct impact on my career perspective. Fields of science natural scienceschemical sciencesinorganic chemistryalkaline earth metalsnatural sciencesphysical sciencesthermodynamicsmedical and health sciencesbasic medicinephysiologysocial scienceslawnatural sciencesmathematicsapplied mathematicsmathematical model Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Topic(s) MSCA-IF-2014-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF) Call for proposal H2020-MSCA-IF-2014 See other projects for this call Funding Scheme MSCA-IF-EF-RI - RI – Reintegration panel Coordinator STICHTING VU Net EU contribution € 177 598,80 Address De boelelaan 1105 1081 HV Amsterdam Netherlands See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
