Objective
The mechanisms underlying metabolic cost of walking are unclear. This is important not only because they provide fundamental insight in human movement, but they are also essential to reduce increased cost of walking in the elderly and impaired. To understand these mechanisms, it is required to know the link between energetics at the human level and the energetics at the muscle level. Whereas the energetics at the human level is experimentally accessible, that at the muscle level is not. Current estimations greatly overestimate actual metabolic cost and hence there is no basis understanding metabolic cost of walking.
In this project I will first ever directly measure oxygen consumption of dynamically contracting muscle fibres. These experiments will be conceptually linked to in vivo experiments measuring oxygen consumption during isolated movements as well as during walking. Using these data and state-of-the art optimization techniques applied to detailed neuro-musculoskeletal models I will link energetics at the muscle level to that of a walking human and provide insight in the mechanisms underlying the metabolic cost of walking.
This grant would allow the applicant to return fully to a EU research environment and would have a very significant and direct impact on my career perspective.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences inorganic chemistry alkaline earth metals
- natural sciences physical sciences thermodynamics
- natural sciences computer and information sciences artificial intelligence computer vision motion analysis
- medical and health sciences basic medicine physiology
- natural sciences mathematics applied mathematics mathematical model
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-RI - RI – Reintegration panel
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2014
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1081 HV Amsterdam
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.