Objective
The goal of the project is the development of new contrast agents for magnetic resonance imaging (MRI) based on the concepts of hyperpolarization and singlet state nuclear magnetic resonance (NMR). Hyperpolarization boosts the detectable NMR signal of the contrast agents by up to 4 orders magnitude and the generation of singlet states conserves the enhanced polarization for a long time, while not giving a directly detectable signal. The NMR signal can subsequently be obtained by chemically breaking the molecular symmetry or by applying radiofrequency pulses. This technique therefore allows for the detection of a NMR signal after minutes instead of seconds compared to state-of-the-art metabolic tracers. A combination of these techniques leads to a nanomolar detection limit of the tracers, which is a remarkable sensitivity for MRI. The chemical transformation which triggers the generation of a hyperpolarized NMR signal may be due to enzymes which are diagnostic of cancer cells. The project leads towards new agents for the in vivo detection and imaging of cancer without the use of ionizing radiation or contrast agents containing dangerous heavy metals. Overall it is planned to develop molecules with nanomolar detection limits upon hyperpolarization, that maintain their traceability for minutes and undergo chemical transformation induced by enzymes, which can be tracked utilizing MRI.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences physical sciences nuclear physics
- medical and health sciences clinical medicine oncology
- natural sciences chemical sciences organic chemistry alcohols
- natural sciences chemical sciences organic chemistry amines
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2014
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
SO17 1BJ SOUTHAMPTON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.