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Macroporous Polymer Monoliths as a Low-Cost Bioanalytical Platform for Biopharmaceutical Glycoprotein

Objective

Glycoprotein therapeutics are widely seen as the next generation of drugs. 80% of new therapeutic drugs in phase 3 development are ‘biologics’. However, the early detection of critical glycosylation changes in biopharma pro-duction (i.e. in the drug producing cells) and the rapid and sensitive identification and separation of closely relat-ed protein-drug glycoforms presents an industry wide problem. This project aims to develop a low-cost and easy-to-produce glycopeptide separation platform. This will be based on highly porous polyHIPE structures obtained from fast and scalable polymerisation and subsequently functionalised with reactive groups. The latter will be employed in the conjugation with novel recombinant lectins that have very selective carbohydrate-binding prop-erties. The separation of closely related glycoproteins will be investigated. Moreover, the integration of the lectin conjugated porous polymers into a device format will be addressed. This is a highly interdisciplinary project at the interface of polymer and material science, biotechnology and separation science. The applicants diverse experi-ence in academic and industrially informed projects makes him an ideal match for this project. It provides a unique environment for the researcher to develop his skills supported by unique scientific and complementary training and accelerate his academic career in applied material science. The dissemination of research results will target the professional audience as well the general public through outreach activities.

Coordinator

ROYAL COLLEGE OF SURGEONS IN IRELAND
Net EU contribution
€ 175 866,00
Address
St Stephen's Green 123
2 Dublin
Ireland

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Region
Ireland Northern and Western Border
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (1)

DUBLIN CITY UNIVERSITY

Participation ended

Ireland
Net EU contribution
€ 0,00
Address
Glasnevin
9 Dublin

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Region
Ireland Eastern and Midland Dublin
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00