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A new generation of AptaSensors

Objective

The aim of this project is to design different next generation libraries of biosensors that will yield ready-to-go analytical tools against any target in unprecedented speed and high affinity. The project intends to focus on aptamers, a new generation of recognition elements that will be integrated into bioelectronics devices.
The huge number of candidates to be tested using a combinatorial trial and error approach will be radically reduced by rationalizing the strategy to design the aptamers. A new virtual screening process will be used for the generation of aptamers by the help of modern molecular modelling tools. The design and binding of large database will be created and screened by adding or mutating molecule bricks (amino acids and DNA), minimizing experimental tests and therefore reducing the research costs.
These sensor elements will be organized in medium to high density nucleic acid and peptide arrays with different transducing principles. In particular, we will design and produce an electrochemical sensor array platform based on screen printing technology together with suitable extraction- and pre-concentration procedures by coupling aptamers to nanoparticles.
The analytical procedures produced will be tested using first standards and then real samples. The target molecules will be analytes related to health and safety control (Xenobiotics: e.g. PCB, pesticides. Mycotoxins: e.g. patulin, nivalenol, Antioxidants: e.g. resveratrol, luteolin).
The proposal has strong focus on development of concrete evolutionary new biosensors for application to diagnostics, food, terrorism threat agents, environmental and new frontiers analysis such as bioanalysis in the space.

Field of science

  • /natural sciences/biological sciences/biochemistry/biomolecules/nucleic acid
  • /natural sciences/chemical sciences/organic chemistry/amines
  • /engineering and technology/environmental biotechnology/biosensing

Call for proposal

H2020-MSCA-IF-2014
See other projects for this call

Funding Scheme

MSCA-IF-GF - Global Fellowships

Coordinator

UNIVERSIDAD COMPLUTENSE DE MADRID
Address
Avenida De Seneca 2
28040 Madrid
Spain
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 239 191,20

Partners (1)

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
United States
Address
Franklin Street 1111, 12 Floor
94607 Oakland Ca
Activity type
Higher or Secondary Education Establishments