Objective
As wild fish stocks are dwindling, aquaculture is increasingly relied upon to supply the growing world demand for fish. However aquaculture operations are largely impeded by our limited understanding of the mechanisms that control reproduction in farmed fish. The gonadotropins LH, FSH and their main stimulator GnRH are key regulators of the reproductive axis in vertebrates. We propose to utilize the unique anatomical traits and rich toolbox of the zebrafish model to dissect the mechanisms driving the differential regulation of LH and FSH. We will adopt a transgenic approach combined with state-of-the-art live imaging techniques to investigate the intricate interplay between GnRH and gonadotropes in the teleost pituitary. Taking advantage of the unique anatomy of the zebrafish, in which LH and FSH are discreet cell types, and the unique expertise of Mollard’s lab in cellular in vivo imaging of the hypothalamus-pituitary tract, we will investigate the functional role of both the circulation and direct contacts (GnRH terminals which directly abut onto gonadotropes) in delivering GnRH signals to target cells and reveal how these signals are interpreted by the gonadotropes to differentially activate LH or FSH cells. The results of the project are expected to provide new insights into the evolution and function of gonadotropin regulation in vertebrates and yield new approaches to control and manipulate the reproductive axis of commercially important species.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- agricultural sciences agriculture, forestry, and fisheries fisheries
- natural sciences biological sciences biochemistry biomolecules
- natural sciences chemical sciences inorganic chemistry alkaline earth metals
- natural sciences biological sciences zoology mammalogy
- natural sciences biological sciences reproductive biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2014
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75794 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.