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Molecular mechanisms of neuronal connectivity - the synaptic code for variability and stereotypy

Objective

Behaviour emerges from an interplay of various brain regions and billions of neurons forming a network. The brain acquires its organization by a series of developmental events. The correct wiring of the brain is crucially important for all brain functions. Nevertheless, the brain is both stereotyped and variable across individuals. Currently only a subset of genes have been identified that shape specificity in connectivity and it is highly elusive what promotes variability in synaptic connectivity and whether this is behaviourally relevant. To work on these questions I have chosen the Drosophila olfactory system, which is well-defined both on the levels of circuitry and behaviour and as such well-suited to answer these question. Furthermore, from the perspective of circuitry, it is particularly appropriate as it is comprised of both deterministic and non-deterministic synaptic connectivity. In a first step to tackle the question, I will perform a screen to identify genes shaping deterministic and non-deterministic neural connectivity. In parallel, I will investigate olfactory behavioural variability in the fly and correlate this to circuitry variations on the morphological, synaptic and electrophysiological level. After identifying genes that are important for connectivity and correlating circuit to behavioural variability, I aim to modify circuit variability to alter behaviour.

Field of science

  • /natural sciences/biological sciences/cell biology/cell signaling
  • /natural sciences/computer and information sciences/artificial intelligence/computer vision
  • /social sciences/psychology
  • /natural sciences/biological sciences/neurobiology

Call for proposal

H2020-MSCA-IF-2014
See other projects for this call

Funding Scheme

MSCA-IF-EF-ST - Standard EF

Coordinator

FREIE UNIVERSITAET BERLIN
Address
Kaiserswerther Strasse 16-18
14195 Berlin
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 142 884

Participants (1)

VIB VZW

Participation ended

Belgium
EU contribution
€ 28 800
Address
Rijvisschestraat 120
9052 Zwijnaarde - Gent
Activity type
Research Organisations