Objective
The development of methods for the transition metal-catalysed functionalization of C-H bonds is revolutionizing synthetic organic chemistry by providing tools to simplify and accelerate the synthesis and modification of a myriad of known and still unknown organic molecules including aromatic compounds. However, in these processes, the ability to discriminate between C-H bonds for subsequent transformation into other functional groups still remains as a major challenge. To date, much progress has been made on developing strategies for the ortho-functionalization of arenes, mainly through the derivatization of the substrates with directing groups. meta-Functionalization approaches, on the other hand, are extremely scarce despite eta-substitution is a widespread motive amongst biologically active molecules.
The research outlined in this proposal aims at developing a process that makes use of CO2 as an invisible directing group leading to an array of novel direct meta-functionalization methodologies. To do so, we envision a one-pot strategy involving a carboxylation ortho to an R group followed by a tandem CO2H directed ortho-functionalization/decarboxylation process that affords the desired meta-functionalized products and releases again the CO2 employed as the directing group.
The realisation of the objectives of this project will push forward the state-of-the art in the area of C-H bond activation by providing step economical access to molecules that are difficult to prepare via conventional multistep routes.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine neurology dementia alzheimer
- natural sciences chemical sciences organic chemistry organic acids
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs
- natural sciences chemical sciences organic chemistry hydrocarbons
- natural sciences chemical sciences organic chemistry aromatic compounds
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
See all projects funded under this programme -
H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2014
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
M13 9PL Manchester
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.