Omics Phenotyping of Endocrine Disease in the General Population

Objective

Metabolomics is a relatively new technology that provides information about levels of human metabolites, the low molecule products at the end (downstream) of the metabolic pathways of human physiology. In theory, metabolite profiles may more closely reflect the clinical phenotype and thus potentially improve risk prediction. Another advantage is that that they can be performed on non-invasive biofluids like urine. Several metabolomics studies have suggested that the metabolite profile of an individual can be used as a predictor of type 2 diabetes. However, evidence from large-scale population-based studies with comprehensive phenotypes of diabetes and thyroid disease is limited. The aim of the project is to identify urine metabolite profiles associated with risk of diabetes and thyroid disease and to investigate pathogenetic pathways by identifying genetic determinants of these metabolites. The project takes advantage of the long tradition of population-based and registry-based epidemiological research in Denmark. The experienced researcher will complete a training program supervised by two recognised Danish research institutions with complementary expertise in the fields of epidemiology and genetics, respectively. Hereby the experienced researcher will achieve competences in the field of statistical modelling of epidemiological data with repeated measures and use of the unique Danish registries for research. Furthermore, during the secondment at the partner institution the experienced researcher will receive training in genetic epidemiology. In return, knowledge of metabolomics will be translated to the beneficiary and partner organizations. It is expected that the results will provide novel insights into the pathophysiology of diabetes and thyroid disease and identify novel biomarkers to improve risk prediction in individuals.

Fields of science

• medical and health sciences › health sciences › public health › epidemiology
• medical and health sciences › basic medicine › physiology › pathophysiology
• medical and health sciences › clinical medicine › endocrinology › diabetes
• medical and health sciences › clinical medicine › hepatology
• natural sciences › chemical sciences › organic chemistry › amines

Programme(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

• MSCA-IF-2014-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF)

Call for proposal

H2020-MSCA-IF-2014

See other projects for this call

Funding Scheme

MSCA-IF-EF-ST - Standard EF

Coordinator

REGION HOVEDSTADEN

Net EU contribution

€ 200 194,80

Address

Kongens Vaenge 2
3400 Hillerod
Denmark

Region

Danmark › Hovedstaden › Nordsjælland

Activity type

Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)

Links

Other funding

€ 0,00