Objective Metabolomics is a relatively new technology that provides information about levels of human metabolites, the low molecule products at the end (downstream) of the metabolic pathways of human physiology. In theory, metabolite profiles may more closely reflect the clinical phenotype and thus potentially improve risk prediction. Another advantage is that that they can be performed on non-invasive biofluids like urine. Several metabolomics studies have suggested that the metabolite profile of an individual can be used as a predictor of type 2 diabetes. However, evidence from large-scale population-based studies with comprehensive phenotypes of diabetes and thyroid disease is limited. The aim of the project is to identify urine metabolite profiles associated with risk of diabetes and thyroid disease and to investigate pathogenetic pathways by identifying genetic determinants of these metabolites. The project takes advantage of the long tradition of population-based and registry-based epidemiological research in Denmark. The experienced researcher will complete a training program supervised by two recognised Danish research institutions with complementary expertise in the fields of epidemiology and genetics, respectively. Hereby the experienced researcher will achieve competences in the field of statistical modelling of epidemiological data with repeated measures and use of the unique Danish registries for research. Furthermore, during the secondment at the partner institution the experienced researcher will receive training in genetic epidemiology. In return, knowledge of metabolomics will be translated to the beneficiary and partner organizations. It is expected that the results will provide novel insights into the pathophysiology of diabetes and thyroid disease and identify novel biomarkers to improve risk prediction in individuals. Fields of science medical and health scienceshealth sciencespublic healthepidemiologymedical and health sciencesbasic medicinephysiologypathophysiologymedical and health sciencesclinical medicineendocrinologydiabetesmedical and health sciencesclinical medicinehepatologynatural scienceschemical sciencesorganic chemistryamines Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Topic(s) MSCA-IF-2014-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF) Call for proposal H2020-MSCA-IF-2014 See other projects for this call Funding Scheme MSCA-IF-EF-ST - Standard EF Coordinator REGION HOVEDSTADEN Net EU contribution € 200 194,80 Address Kongens vaenge 2 3400 Hillerod Denmark See on map Region Danmark Hovedstaden Nordsjælland Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
