Objective
This proposal describes my aim to use a uniquely large multigenerational family to better understand the genetic underpinnings of mood disorders: the Brazilian Bipolar Family (BBF). The family has a high incidence of mood disorders, featuring diminishing age of onset over generations and assortative mating, whereby many of the marriages in the family are between individuals with a psychiatric disorder. Mood disorders are leading contributors to the global burden of disease. Bipolar disorder is characterized by periods of elevated mood and periods of depression. Major depressive disorder is characterized by pervasive and persistent low mood, low self-esteem and loss of interest or pleasure in normally enjoyable activities. Heritability estimates are 37% for MDD and up to 75% for BP. The current picture for complex disorders is of a genetic architecture consisting of both common and rare variants contributing risk. Genetic studies of mood disorders have not yet individual variants/genes accounting for a large increase in risk. The effect of common variants in the family context is unclear. I propose to utilize the BBF as a unique resource for studying both common and rare variation in mood disorders. Its size offers a powerful means for mapping genetic loci for mood disorders that are individually rare but common within the family. It also provides us with a unique model in which to analyse individual genetic risk profiles, utilizing the large sample size of and predictive ability of previous case-control association studies for each family member into a polygenic risk score. This will also allow me to assess assortative mating, which may act to increase polygenic risk to mood disorders over generations. I will develop an approach which will allow me to incorporate genome-wide case-control study results into family studies – something with broad utility for the field. My study will shed light on the genetic pathology of mood disorders, aiding prevention and treatment.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- social sciences sociology family studies
- social sciences sociology social issues social inequalities
- medical and health sciences basic medicine pathology
- medical and health sciences clinical medicine psychiatry schizophrenia
- natural sciences biological sciences genetics genomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2014
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
WC2R 2LS London
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.