Objective
This project develops a continuous flow microprocess for the synthesis of pure vitamin D3 from 7-dehydrocholesterol. Such approach will be achieved by applying a massive and combined photo-high-T intensification. Such conditions are only possible by employing microreactors according to Novel Process Windows postulates: The aim is to boost the reaction kinetics both by providing a high photon number density and through thermal intensification. In addition, supercritical conditions will be tested as third intensification option. Besides the normal time-invariant, continuous photon exposure, a new photochemical approach based on intense LED-photo-pulses will be tested to enhance the selectivity. To have a full process scheme covered, a continuous micro-plug-flow crystallization operating at fast mixing, short residence time and supersaturated conditions will be developed.
Vitamin D3 is a very important nutrient needed to prevent all types of disease. As its deficiency is now recognized in the developed world, a significant increase demand in the market is expected. That is why it is envisaged a multiple impact of this project mainly in European society, but also for pharmaceutical companies and SMEs, representing for both a ‘Window of Opportunity’. Particularly photo-high-T could be also tested in other photochemical reactions; such as the synthesis of vitamin D2 or, by using other photocatalysts such as TiO2, in the N-ethylation of benzylamine.
This multidisciplinary proposal includes Life-Cycle-Assessment (LCA) to holistically evaluate in ex-ante fashion different process intensification scenarios. At the project end, LCA will benchmark the flow achievements to the current batch production, looking towards its industrial transfer. For the fellow, this proposal means an extension of his previous research, but with novel and challenging additional aspects,providing with a range of training options in research and transferable skills for building his independent career.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology environmental engineering ecosystem-based management climatic change mitigation
- natural sciences chemical sciences inorganic chemistry transition metals
- natural sciences chemical sciences physical chemistry photochemistry
- natural sciences physical sciences optics laser physics
- natural sciences physical sciences theoretical physics particle physics photons
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-CAR - CAR – Career Restart panel
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2014
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
5612 AE Eindhoven
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.