Objective
Puberty, a key developmental period when the reproductive capacity is attained and sexual and somatic maturation completed, is under the control of a complex series of regulatory mechanisms that are sensitive to endogenous factors and environmental cues. However, characterization of the neuro-hormonal basis of puberty remains incomplete. A wealth of evidence has demonstrated the existence of reciprocal communications between glial cells and neurons; glial cells having an essential role in regulation of the functional activity of the nervous system. In this context, it is well establish that glial cells play an important role in neuroendocrine regulation and participate in sexual differentiation of neuronal connectivity of brain regions involved in the control of puberty. In addition, preliminary studies have demonstrated that kisspeptins induce changes in markers of glial cell activity. Based on this preliminary data, the aim of this proposal is to provide better knowledge of the role of glial cells in the control of puberty and their interplay with kisspeptins, as major gatekeepers of puberty onset in mammals. To this end, we will used both Kiss1 KO and Gpr54-βgal models generated by the host laboratory, which will allow the study of direct effects of kisspeptins on glial cells. In addition, we will generate a mouse model with deletion of Gpr54 (kisspeptin receptor) only in glial cells, to define their precise role in the control of puberty. Implementation of this project will expand our knowledge of the mechanisms for the control of puberty and its deviations, whose prevalence has notably increased worldwide.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- medical and health sciences clinical medicine oncology
- medical and health sciences basic medicine physiology
- medical and health sciences clinical medicine endocrinology
- medical and health sciences health sciences nutrition obesity
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2014
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
CB2 1TN CAMBRIDGE
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.