Periodic Reporting for period 1 - IPEIBD (Identification of promoters and enhancers specific for inflammatory bowel disease and its subtypes)
Reporting period: 2015-06-01 to 2017-05-31
We identified a set of biomarkers (promoters and enhancers) that could predict IBD diagnosis (Crohn’s disease, ulcerative colitis or control) with an accuracy of 85%, using targeted microfluidics qPCR, where the prediction method was trained on one group of patients and evaluated in an independent group. This shows the potential for qPCR-based diagnostics methods for IBD, complementing current histology-based approaches. More generally, our results constitute a foundation for understanding the molecular pathology and genetics of IBD.