Objective
All metazoans harbour considerable numbers of commensal microorganisms in the gut, named microbiota, that contribute to many aspects of normal host physiology. Scientific research has provided invaluable contributions to our understanding of the relationship between host and its microbiota; however, the molecular mechanisms through which the microbiota exerts its beneficial influence are still largely undefined. The meta’omics revolution is promoting an explosion of interest in how the gut bacterial community impacts physiology and propensity to disease. In addition, gnotobiotic model organisms provide unique opportunities to study host-microbiota interplay with a level of experimental control that is not achievable in human studies. The coupling of those two approaches should allow to pinpoint key mechanisms underlying this mutually beneficial relationship. This research proposal aims to use those approaches to understand the bacterial genetic pathways mediating host benefits. To this end, we will apply in vivo experimental evolution to mutualistic bacteria, using gnotobiotic animal models. The work will investigate the association between the host model Drosophila melanogaster and one of its most abundant commensal bacteria, Lactobacillus plantarum, which was demonstrated to be beneficial to its host physiology by promoting juvenile growth and maturation.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences nutrition
- medical and health sciences basic medicine pathology
- medical and health sciences basic medicine physiology
- medical and health sciences clinical medicine embryology
- natural sciences biological sciences microbiology bacteriology bacteriomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2014
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75794 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.