Objective Generating appropriate behavioural responses to sensory cues is crucial to ensure the survival of species, and relies on synaptic integration – the process by which individual neurons convert synaptic input into action potential output. How the brain performs the computations that produce specific behaviours is an essential question in Neuroscience and has direct relevance to human health and well-being. The aim of this project is to determine mechanisms of synaptic integration in a circuit underlying aggressive behaviour in the mouse, and analyse how single neurons in the ventromedial hypothalamic nucleus (VMH) contribute to computations leading to aggressive behaviour. By combining behavioural, genetic, electrophysiological and optical techniques, this project will determine: (i) the biophysical properties and local connectivity of VMH neurons, (ii) the anatomical localization of synaptic inputs along their dendritic tree, and (iii) how VMH neurons that drive aggressive behaviour integrate synaptic input from anatomically and molecularly-defined pathways. Recent in vitro studies have uncovered a previously unknown degree of complexity of information processing that single neurons can perform. While a lot of these studies combining electrophysiological, optical and computational approaches have focused on cortical circuits important for learned behaviours, innate behaviours have not benefited from such experimental and analysis framework. This project will become the first to implement such multidisciplinary approach to determine the mechanisms of synaptic integration in the hypothalamus. The results of this study will provide mechanisms of how VMH neurons generate patterns of activity that lead to aggression, which will advance our understanding of information processing in fundamental innate circuits and contribute to development of solutions for control of aggressive behaviour. Fields of science natural sciencesbiological sciencesneurobiologymedical and health sciencesmedical biotechnologygenetic engineeringgene therapynatural scienceschemical sciencesinorganic chemistryalkaline earth metalsnatural sciencescomputer and information sciencesdata sciencedata processingnatural sciencesbiological sciencesmolecular biology Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Topic(s) MSCA-IF-2014-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF) Call for proposal H2020-MSCA-IF-2014 See other projects for this call Funding Scheme MSCA-IF-EF-ST - Standard EF Coordinator UNIVERSITY COLLEGE LONDON Net EU contribution € 53 096,11 Address GOWER STREET WC1E 6BT London United Kingdom See on map Region London Inner London — West Camden and City of London Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 53 096,12 Participants (1) Sort alphabetically Sort by Net EU contribution Expand all Collapse all UNITED KINGDOM RESEARCH AND INNOVATION Participation ended United Kingdom Net EU contribution € 142 358,69 Address POLARIS HOUSE NORTH STAR AVENUE SN2 1FL Swindon See on map Region South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Swindon Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 142 358,69