Objective
Artificial cells are synthetic compartments that are able to mimic one or more properties of natural cells and provide valuable avenues for the study of fundamental cellular functions. However, thus far there are no examples of synthetic systems/materials that can achieve self-replication. Therefore the key aim of this project is to create artificial self-dividing protocells. I will build a platform that combines synthetic chemistry, cell biology and microfluidics to prepare cell-like systems. Monodisperse picoliter multiple all-aqueous droplet systems (e.g. liposomes) generated by microfluidics will be utilized to construct self-dividing protocells. To achieve division, the so-called Z-ring of the bacterial divisome will be incorporated in droplets, together with an energy-generation system. I have extensive experience in microfluidics research and especially in the preparation of multiple emulsions with complex compartments, which I will exploit in this project. At Radboud University (RU), I will obtain new skills and expertise in biochemistry and biology such as in vitro gene expression, chemical reaction networks, and bottom-up synthetic biology. Importantly, the reconstitution of an artificial cell divisome would lead to a deeper understanding of the biophysical principles of cellular behavior and will be the most fundamental step towards construction of artificial cells. I believe this in vitro reconstituted system provides a revolutionary new platform for biomimetic research.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences physical sciences classical mechanics fluid mechanics microfluidics
- natural sciences biological sciences synthetic biology
- natural sciences physical sciences optics microscopy
- natural sciences biological sciences biochemistry biomolecules lipids
- natural sciences chemical sciences physical chemistry
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2014
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
6525 XZ Nijmegen
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.