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Role of the sorting receptor SorCS1 in controlling excitation/inhibition balance in neural circuits.

Objective

Controlling the precise balance between excitation and inhibition (E/I balance) is critical for information processing in the brain. A perturbed E/I balance has been implicated in the etiology of a wide range of neuropsychiatric disorders. The factors that dictate the balance between excitatory and inhibitory synaptic transmission are still poorly defined, but trans-synaptic interactions between adhesion molecules such as neurexins and neuroligins are thought to be important. The host laboratory recently identified the sorting receptor SorCS1 as a key regulator of the synaptic abundance of glutamate receptors and adhesion molecules, including neurexins and neuroligins. SorCS1 has been associated with a variety of neural disorders, including autism, schizophrenia, and Alzheimer’s disease. I hypothesize that SorCS1 controls E/I balance in the brain by regulating the synaptic abundance of cell surface receptors. I shall test this hypothesis via the following specific aims:

Aim 1: To analyse whether SorCS1 regulates synaptic trafficking of adhesion molecules and neurotransmitter receptors under basal conditions and during synaptic activity.

Aim 2: To define how SorCS1 affects excitatory and inhibitory synapse function in vitro and in vivo.

Aim 3: To determine whether perturbed SorCS1 levels and disease-associated SorCS1 mutations affect E/I balance in neural circuits.

Fields of science (EuroSciVoc)

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Keywords

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Programme(s)

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Topic(s)

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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)

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Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) H2020-MSCA-IF-2014

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Coordinator

VIB VZW
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 160 800,00
Address
SUZANNE TASSIERSTRAAT 1
9052 ZWIJNAARDE - GENT
Belgium

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Region
Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent
Activity type
Research Organisations
Links
Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 160 800,00
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