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MicroRNAs as therapeutic targets for ARVC.

Objective

ARVC is a hereditary disease mainly characterised by the progressive substitution of the myocardium with fatty or fibro-fatty tissue involving predominantly the right ventricle. Clinically, ARVC shows wide variation between individuals. Together with modifier genes, common sequence variants, and environmental as well as endogenous factors, epigenetic modifiers such as miRNAs are hypothesized to be potential targets for disadvantageous environmental stimuli and may lead to the onset of complex and heterogeneous diseases such as ARVC. The main research objective of this EF is to assess and validate the relevance of disease mechanisms underlying the development of ARVC and to identify novel RNA-based targets in mouse models and ARVC patients. The EF programme comprises two tightly linked components – research and complementary training - that will be complemented with secondments in two (non-) academic organisations active in the field of molecular cardiology. The host organisations are strongly committed to enhancing the creative and innovative potential of the ER who wishes to diversify her individual competence in terms of skill acquisition to become a successful European scientist.

Fields of science (EuroSciVoc)

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Programme(s)

Multi-annual funding programmes that define the EU’s priorities for research and innovation.

Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

MSCA-IF-EF-ST - Standard EF

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Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) H2020-MSCA-IF-2014

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Coordinator

UNIVERSITEIT MAASTRICHT
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 165 598,80
Address
MINDERBROEDERSBERG 4
6200 MD Maastricht
Netherlands

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Region
Zuid-Nederland Limburg (NL) Zuid-Limburg
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 165 598,80
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