Objective
Axonal endoplasmic reticulum (ER) is a poorly characterised compartment that is mainly tubular, smooth, and forms a network for long distances along axons. Many mutations for the motor axon degeneration disease, hereditary spastic paraplegia (HSP), affect proteins that model ER shape. The Fellow will test the model that these proteins help form axonal ER, which is disrupted when these proteins are mutated. The time for this is opportune; the host lab has developed tools to detect impaired axon ER organisation in Drosophila; and new HSP genes, some encoding ER proteins of unknown function, are being identified continuously in human patients. To identify proteins involved in its formation, the Fellow will test ER-localized HSP gene products, both singly and in multiply mutant genotypes, for roles in ER organisation in larval motor axons. She will also test whether similar defects appear in long motor and sensory axons in live adults as they age. Finally she will test the effects of HSP protein loss on the finer structure of ER and its association with mitochondria. Through this work the Fellow will help pioneer characterisation of a poorly understood but important cell compartment: how it is formed and some effects of disrupting it. Along with the broader research and training environment, this will help her to develop a profile for her own work in this area.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences basic medicine pathology
- medical and health sciences health sciences nutrition obesity
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2014
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
CB2 1TN CAMBRIDGE
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.