Objective
This project aims to offer a solid solution to the dwindling effectiveness of antibiotics against infectious diseases caused by the development of antimicrobial resistant (AMR) bacteria. The core of this proposal is to implement an innovative synthesis-oriented strategy to access truncated derivatives of abyssomicin C, a natural product that has shown especially promising antimicrobial activity against the most common strains of antimicrobial resistant bacteria. The multiple routes proposed for the synthesis of the truncated core scaffold are short, robust and amenable for many different variations. This will open up for the possibility to easily synthesise a library of differently adorned abyssomicin C truncated analogues whose antimicrobial activity will be evaluated. Structure activity relationship (SAR) studies aided by computational modeling will be used as an integrated action in the identification of new potent antimicrobial agents.
The complementary expertise of the applicant, the host laboratories and the leading experts that will collaborate within this project will be crucial for the realization of all aspects of this multifaceted project. The achievement of the project goals will have a deep impact not only in the scientific community but also on the healthcare systems in Europe and globally.
This EF postdoctoral training proposal will represent a unique opportunity to the candidate to expand his scientific network in both the academia and the industry, greatly broaden his spheres of action, strengthening his professional maturity.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- natural sciences biological sciences microbiology bacteriology
- medical and health sciences health sciences infectious diseases
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antibiotics
- medical and health sciences basic medicine pharmacology and pharmacy drug resistance antibiotic resistance
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2014
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
405 30 Goeteborg
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.