Viruses are the smallest form of life and are important not only in human health, but also as tools in genetics and molecular biology. The atomic-level characterization of viral particles can help designing antiviral treatments as well as advance our understanding of the fundamental basis of virus infection, replication, assembly and maturation. Over the last years, solid-state NMR (ssNMR) has developed into a powerful structural tool to study the structure and dynamics of solid biological samples at atomic resolution. However, proteins of large size or that are available in limited amounts were inaccessible to site-specific ssNMR studies. Exploiting the unique equipment available at the host institution, the project set out to remove the current bottlenecks and developped improved dynamic nuclear polarization (DNP)-enhanced ssNMR methodology to push forward the limits of applicability of this technique to macromolecular assemblies, opening new avenues to ssNMR in structural biology, particularly, for the characterization of viruses.