The main result from the project is the development of a short and efficient synthetic route for the generation of truncated tirandamycin derivatives (Fig 1). The development of the synthetic strategy turned out to be extremely challenging and time consuming due to e.g. instability of initial key intermediates and the need to develop entirely new reaction sequences, and have generated a short and highly efficient synthetic protocol for the prepapration of truncated tiranadmycin derivatives on gram scale (month 0-24).
The synthetic developments have been guided by computational chemistry (docking; month 12-20) and in part biological testing (still ongoing; month 20-24).
A manuscript based on the results generated by the researcher Dr. Tania Jiménez throughout the project will be submitted (manuscript in preparation) to a high impact journal (e.g. Angewant Chemie) as soon as the biological evaluation of the truncated tirandamycin derivatives are completed.
Parts of the results have been presented at international research conferences: Bienal de quimica organica in Huelva, Spain (14-17 June 2016), The SISOC XI in Basque Country (13-15 July 2016) and ACS international conference in San Francisco, USA (3-6 April 2017).
In addition the researcher has completed a training program, that included learning new techniques (e.g. how to run enzymatic assays and carry out docking), project management, leadership training (being responsible for two graduate students) and gaining skills such as motivating others, communication, reviewing progress, applying practical strategies to get the best from a research team, getting and managing finances, writing papers, projects and grant proposals, and presenting scientific results. The researcher has been involved in the organization and implementation of the annual ¨day of open door¨ aiming at closing the gap between academia and the broad public and at demonstrating the impact of research on innovation, prosperity and public welfare. She had also given science master-classes during the Annual High School Days and had participated in the organization of the faculty´s job fair.
