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Predicting Cardiotoxicity Induced by Kinase Inhibitors: From Systems Biology to Systems Pharmacology

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Mechanistic Systems Modeling to Improve Understanding and Prediction of Cardiotoxicity Caused by Targeted Cancer Therapeutics

Author(s): Jaehee V. Shim, Bryan Chun, Johan G. C. van Hasselt, Marc R. Birtwistle, Jeffrey J. Saucerman, Eric A. Sobie
Published in: Frontiers in Physiology, 8, 2017, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2017.00651

Systems pharmacology-based identification of pharmacogenomic determinants of adverse drug reactions using human iPSC-derived cell lines

Author(s): J.G. Coen van Hassselt, Ravi Iyengar
Published in: Current Opinion in Systems Biology, 4, 2017, Page(s) 9-15, ISSN 2452-3100
Publisher: Elsevier
DOI: 10.1016/j.coisb.2017.05.006