Deliverables
Developing disease understanding.
Evaluation of progression-informed network propagation models for prion disease. Implications for network models in other diseases, particularly dementia.
Test the prion hypothesis of disease propagation, among others.
Advanced estimation of subtypes to identify distinct phenotypes.
Provisionally titled: “Diagnosis, staging, and prognosis through disease progression modelling”. To include international speakers from science and industry, with personal invitations extended to Clinical Trial Management companies and Clinical Trial units. The dementia software tool will be demonstrated at the workshop, along with other models.
Demonstrating the system on clinical trial data.
Basic multimodal models to understand normal and abnormal neurological development.
Examine the potential of a model-based staging system for early assessment of the risk of neurodevelopment disorder.
Influence of genetics and clinical factors on neurodevelopment.
Providing fundamental new knowledge on dementia subtypes.
Dissemination of our framework.
Combining useful elements from basic models of MS.
ncluding dementia in our web-based application.
Communication (internal and external) of results, and for online meetings.
Getting a reference point (normal ageing) for sporadic neurological diseases.
Multimodal models of changes in prion disease.
Network models from WP4 exploring links between observed pathology.
Summarise the outcomes of EuroPOND (closely matching the Final Report).
Combining useful elements from basic models of neurodevelopment.
Combining useful elements from basic models of prion disease.
Developing disease understanding.
Dissemination of our unified modelling framework.
A new formulation of these models.
Shed light on debate over traditional clinical subtypes.
How such models fit into the framework.
Advancing models for features and robustness.
Answering key questions.
Models of dementia enhanced by inclusion of the effects of normal ageing, to highlight the pathological effects.
Update to the event-based model of disease progression.
Advanced estimation of subtypes to identify distinct phenotypes.
New knowledge on normal ageing for enhancing models of neurological diseases.
Multimodal models of changes in MS.
Influence of genetics and demographics on normal ageing and dementia.
This will have primary Impact within the research community, but will be developed with clinical usage in mind.
A new formulation of these models.
For ensuring consistency and soundness of conclusions across application areas.
Updated from earlier prototype in D6.2.
Searching for OpenAIRE data...
Publications
Author(s): Riccardo Pascuzzo, Vikram Venkatraghavan, Marco Moscatelli, Marina Grisoli, Esther E. Bron, Stefan Klein, Janis Blevins, Gianmarco Castelli, Lawrence B. Schonberger, Pierluigi Gambetti, Brian S. Appleby, Alberto Bizzi
Published in: 2020
Publisher: Mirasmart
Author(s): Riccardo Pascuzzo, Alexandra L. Young, Neil P. Oxtoby, Janis Blevins, Gianmarco Castelli, Pierluigi Gambetti, Brian S. Appleby, Daniel C. Alexander, and Alberto Bizzi
Published in: 2020
Publisher: Mirasmart
Author(s): Alexandre Bone, Olivier Colliot, Stanley Durrleman
Published in: 2018 IEEE/CVF Conference on Computer Vision and Pattern Recognition, 2018, Page(s) 9271-9280, ISBN 978-1-5386-6420-9
Publisher: IEEE
DOI: 10.1109/cvpr.2018.00966
Author(s): Jorge Samper-Gonzalez, Ninon Burgos, Simona Bottani, Marie-Odile Habert, Theodoros Evgeniou, Stephane Epelbaum, Olivier Colliot
Published in: Medical Imaging 2019: Image Processing, 2019, Page(s) 30, ISBN 9781-510625464
Publisher: SPIE
DOI: 10.1117/12.2512430
Author(s): Alexandre Bône, Olivier Colliot, Stanley Durrleman
Published in: 2019
Publisher: HAL Id
Author(s): Alexandre Bône, Benoît Martin, Maxime Louis, Olivier Colliot, Stanley
Durrleman
Published in: 2019
Publisher: HAL
Author(s): Manon Ansart, Stéphane Epelbaum, Giulia Bassignana, Alexandre Bône,
Simona Bottani, Tiziana Cattai, Raphael Couronne, Johann Faouzi, Igor
Koval, Maxime Louis, et al.
Published in: 2019
Publisher: HAL
Author(s): Alexandre Bône, Olivier Colliot, Stanley Durrleman
Published in: 2019
Publisher: https://hal.inria.fr/hal-02091549v4/document
Author(s): Igor Koval, Stéphanie Allassonnière, Stanley Durrleman
Published in: 2019
Publisher: HAL
Author(s): Marco Lorenzi, Maurizio Filippone, Daniel C. Alexander, Sebastien Ourselin
Published in: 2016
Publisher: Cornell University Library
Author(s): Alexandre Bône, Maxime Louis, Alexandre Routier, Jorge Samper, Michael
Bacci, Benjamin Charlier, Olivier Colliot, Stanley Durrleman
Published in: 2017
Publisher: https://hal.archives-ouvertes.fr/
Author(s): Alexandre Bône, Olivier Colliot, Stanley Durrleman
Published in: International Journal of Computer Vision, 128/12, 2020, Page(s) 2873-2896, ISSN 0920-5691
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s11263-020-01343-w
Author(s): Joana Sa de Almeida, Djalel-Eddine Meskaldji, Serafeim Loukas, Lara Lordier, Laura Gui, François Lazeyras, Petra S. Hüppi
Published in: NeuroImage, 225, 2021, Page(s) 117440, ISSN 1053-8119
Publisher: Academic Press
DOI: 10.1016/j.neuroimage.2020.117440
Author(s): Riccardo Pascuzzo, Neil P. Oxtoby, Alexandra L. Young, Janis Blevins, Gianmarco Castelli, Sara Garbarino, Mark L. Cohen, Lawrence B. Schonberger, Pierluigi Gambetti, Brian S. Appleby, Daniel C. Alexander, Alberto Bizzi
Published in: Acta Neuropathologica, 140/2, 2020, Page(s) 169-181, ISSN 0001-6322
Publisher: Springer Verlag
DOI: 10.1007/s00401-020-02168-0
Author(s): Alberto Bizzi, Riccardo Pascuzzo, Janis Blevins, Marco E. M. Moscatelli, Marina Grisoli, Raffaele Lodi, Fabio M. Doniselli, Gianmarco Castelli, Mark L. Cohen, Aymeric Stamm, Lawrence B. Schonberger, Brian S. Appleby, Pierluigi Gambetti
Published in: Annals of Neurology, 2020, ISSN 0364-5134
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/ana.25983
Author(s): Hanne Struyfs, Diana Maria Sima, Melissa Wittens, Annemie Ribbens, Nuno Pedrosa de Barros, Thanh Vân Phan, Maria Ines Ferraz Meyer, Lene Claes, Ellis Niemantsverdriet, Sebastiaan Engelborghs, Wim Van Hecke, Dirk Smeets
Published in: NeuroImage: Clinical, 26, 2020, Page(s) 102243, ISSN 2213-1582
Publisher: Elsevier BV
DOI: 10.1016/j.nicl.2020.102243
Author(s): Junhao Wen, Elina Thibeau-Sutre, Mauricio Diaz-Melo, Jorge Samper-González, Alexandre Routier, Simona Bottani, Didier Dormont, Stanley Durrleman, Ninon Burgos, Olivier Colliot
Published in: Medical Image Analysis, 63, 2020, Page(s) 101694, ISSN 1361-8415
Publisher: Elsevier BV
DOI: 10.1016/j.media.2020.101694
Author(s): L. Gui, S. Loukas, F. Lazeyras, P.S. Hüppi, D.E. Meskaldji, C. Borradori Tolsa
Published in: NeuroImage, 185, 2019, Page(s) 728-741, ISSN 1053-8119
Publisher: Academic Press
DOI: 10.1016/j.neuroimage.2018.06.034
Author(s): W. Huizinga, D.H.J. Poot, M.W. Vernooij, G.V. Roshchupkin, E.E. Bron, M.A. Ikram, D. Rueckert, W.J. Niessen, S. Klein
Published in: NeuroImage, 169, 2018, Page(s) 11-22, ISSN 1053-8119
Publisher: Academic Press
DOI: 10.1016/j.neuroimage.2017.10.040
Author(s): Elisabeth J. Vinke, Marius de Groot, Vikram Venkatraghavan, Stefan Klein, Wiro J. Niessen, M. Arfan Ikram, Meike W. Vernooij
Published in: Neurobiology of Aging, 71, 2018, Page(s) 32-40, ISSN 0197-4580
Publisher: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2018.07.001
Author(s): Igor Koval, Jean-Baptiste Schiratti, Alexandre Routier, Michael Bacci, Olivier Colliot, Stéphanie Allassonnière, Stanley Durrleman
Published in: Frontiers in Neurology, 9, 2018, ISSN 1664-2295
Publisher: Frontiers Research Foundation
DOI: 10.3389/fneur.2018.00235
Author(s): Arman Eshaghi, Razvan V Marinescu, Alexandra L Young, Nicholas C Firth, Ferran Prados, M Jorge Cardoso, Carmen Tur, Floriana De Angelis, Niamh Cawley, Wallace J Brownlee, Nicola De Stefano, M Laura Stromillo, Marco Battaglini, Serena Ruggieri, Claudio Gasperini, Massimo Filippi, Maria A Rocca, Alex Rovira, Jaume Sastre-Garriga, Jeroen J G Geurts, Hugo Vrenken, Viktor Wottschel, Cyra E Leurs, Berna
Published in: Brain, 141/6, 2018, Page(s) 1665-1677, ISSN 0006-8950
Publisher: Oxford University Press
DOI: 10.1093/brain/awy088
Author(s): Anne Bertrand, Junhao Wen, Daisy Rinaldi, Marion Houot, Sabrina Sayah, Agnès Camuzat, Clémence Fournier, Sabrina Fontanella, Alexandre Routier, Philippe Couratier, Florence Pasquier, Marie-Odile Habert, Didier Hannequin, Olivier Martinaud, Paola Caroppo, Richard Levy, Bruno Dubois, Alexis Brice, Stanley Durrleman, Olivier Colliot, Isabelle Le Ber
Published in: JAMA Neurology, 75/2, 2018, Page(s) 236, ISSN 2168-6149
Publisher: American Medical Association
DOI: 10.1001/jamaneurol.2017.4266
Author(s): Vikram Venkatraghavan, Esther E. Bron, Wiro J. Niessen, Stefan Klein
Published in: NeuroImage, 186, 2019, Page(s) 518-532, ISSN 1053-8119
Publisher: Academic Press
DOI: 10.1016/j.neuroimage.2018.11.024
Author(s): Neil P Oxtoby, Alexandra L Young, David M Cash, Tammie L S Benzinger, Anne M Fagan, John C Morris, Randall J Bateman, Nick C Fox, Jonathan M Schott, Daniel C Alexander
Published in: Brain, 141/5, 2018, Page(s) 1529-1544, ISSN 0006-8950
Publisher: Oxford University Press
DOI: 10.1093/brain/awy050
Author(s): Alexandra L Young, Razvan V Marinescu, Neil P Oxtoby, Martina Bocchetta, Keir Yong, Nicholas C Firth, David M Cash, David L Thomas, Katrina M Dick, Jorge Cardoso, John van Swieten, Barbara Borroni, Daniela Galimberti, Mario Masellis, Maria Carmela Tartaglia, James B Rowe, Caroline Graff, Fabrizio Tagliavini, Giovanni B Frisoni, Robert Laforce, Elizabeth Finger, Alexandre de Mendonça, Sandro Sorbi
Published in: Nature Communications, 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-05892-0
Author(s): Marco Lorenzi, Maurizio Filippone, Giovanni B. Frisoni, Daniel C. Alexander, Sebastien Ourselin
Published in: NeuroImage, 190, 2019, Page(s) 56-68, ISSN 1053-8119
Publisher: Academic Press
DOI: 10.1016/j.neuroimage.2017.08.059
Author(s): Neil P. Oxtoby, Sara Garbarino, Nicholas C. Firth, Jason D. Warren, Jonathan M. Schott, Daniel C. Alexander
Published in: Frontiers in Neurology, 8, 2017, ISSN 1664-2295
Publisher: Frontiers Research Foundation
DOI: 10.3389/fneur.2017.00580
Author(s): Jorge Samper-González, Ninon Burgos, Simona Bottani, Sabrina Fontanella, Pascal Lu, Arnaud Marcoux, Alexandre Routier, Jérémy Guillon, Michael Bacci, Junhao Wen, Anne Bertrand, Hugo Bertin, Marie-Odile Habert, Stanley Durrleman, Theodoros Evgeniou, Olivier Colliot
Published in: NeuroImage, 183, 2018, Page(s) 504-521, ISSN 1053-8119
Publisher: Academic Press
DOI: 10.1016/j.neuroimage.2018.08.042
Author(s): Răzvan V. Marinescu, Arman Eshaghi, Marco Lorenzi, Alexandra L. Young, Neil P. Oxtoby, Sara Garbarino, Sebastian J. Crutch, Daniel C. Alexander
Published in: NeuroImage, 192, 2019, Page(s) 166-177, ISSN 1053-8119
Publisher: Academic Press
DOI: 10.1016/j.neuroimage.2019.02.053
Author(s): Meike W. Vernooij, Bas Jasperse, Rebecca Steketee, Marcel Koek, Henri Vrooman, M. Arfan Ikram, Janne Papma, Aad van der Lugt, Marion Smits, Wiro J. Niessen
Published in: NeuroImage: Clinical, 20, 2018, Page(s) 374-379, ISSN 2213-1582
Publisher: Elsevier BV
DOI: 10.1016/j.nicl.2018.08.004
Author(s): Lotte G. M. Cremers, Wyke Huizinga, Wiro J. Niessen, Gabriel P. Krestin, Dirk H. J. Poot, M. Arfan Ikram, Jyrki Lötjönen, Stefan Klein, Meike W. Vernooij
Published in: Frontiers in Aging Neuroscience, 11, 2020, ISSN 1663-4365
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnagi.2019.00379
Author(s): Damiano Archetti, Silvia Ingala, Vikram Venkatraghavan, Viktor Wottschel, Alexandra L. Young, Maura Bellio, Esther E. Bron, Stefan Klein, Frederik Barkhof, Daniel C. Alexander, Neil P. Oxtoby, Giovanni B. Frisoni, Alberto Redolfi
Published in: NeuroImage: Clinical, 24, 2019, Page(s) 101954, ISSN 2213-1582
Publisher: Elsevier BV
DOI: 10.1016/j.nicl.2019.101954
Author(s): Sara Garbarino, Marco Lorenzi, Neil P Oxtoby, Elisabeth J Vinke, Razvan V Marinescu, Arman Eshaghi, M Arfan Ikram, Wiro J Niessen, Olga Ciccarelli, Frederik Barkhof, Jonathan M Schott, Meike W Vernooij, Daniel C Alexander
Published in: eLife, 8, 2019, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.49298
Author(s): Elisabeth J. Vinke, Wyke Huizinga, Martin Bergtholdt, Hieab H. Adams, Rebecca M.E. Steketee, Janne M. Papma, Frank J. de Jong, Wiro J. Niessen, M. Arfan Ikram, Fabian Wenzel, Meike W. Vernooij
Published in: Neurobiology of Aging, 84, 2019, Page(s) 9-16, ISSN 0197-4580
Publisher: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2019.07.008
Author(s): Viktor Wottschel, Declan T. Chard, Christian Enzinger, Massimo Filippi, Jette L. Frederiksen, Claudio Gasperini, Antonio Giorgio, Maria A. Rocca, Alex Rovira, Nicola De Stefano, Mar Tintoré, Daniel C. Alexander, Frederik Barkhof, Olga Ciccarelli
Published in: NeuroImage: Clinical, 24, 2019, Page(s) 102011, ISSN 2213-1582
Publisher: Elsevier BV
DOI: 10.1016/j.nicl.2019.102011
Author(s): Lara Lordier, Djalel-Eddine Meskaldji, Frédéric Grouiller, Marie P. Pittet, Andreas Vollenweider, Lana Vasung, Cristina Borradori-Tolsa, François Lazeyras, Didier Grandjean, Dimitri Van De Ville, Petra S. Hüppi
Published in: Proceedings of the National Academy of Sciences, 2019, Page(s) 201817536, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1817536116
Author(s): Claire Cury, Marco Lorenzi, David Cash, Jennifer M. Nicholas, Alexandre Routier, Jonathan Rohrer, Sebastien Ourselin, Stanley Durrleman, Marc Modat
Published in: Springer, 2016, Page(s) 63-75, ISSN 0018-1560
Publisher: Kluwer Academic Publishers
DOI: 10.1007/978-3-319-51237-2_6
Author(s): Razvan Valentin Marinescu, Alexandra L. Young, Neil P. Oxtoby, Nicholas C. Firth, Marco Lorenzi, Arman Eshaghi, Viktor Wottschel, M. Jorge Cardoso, Marc Modat, Keir Yong, Silvia Primativo, Nick C. Fox, Manja Lehmann, Timothy J. Shakespeare, Sebastian J. Crutch, Daniel C. Alexander
Published in: Alzheimer's & Dementia, 12/7, 2016, Page(s) P401-P402, ISSN 1552-5260
Publisher: Elsevier BV
DOI: 10.1016/j.jalz.2016.06.756
Author(s): Neil P. Oxtoby, Daniel C. Alexander
Published in: Current Opinion in Neurology, 30/4, 2017, Page(s) 371-379, ISSN 1350-7540
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/WCO.0000000000000460
Author(s): Iris Dekker, Menno M. Schoonheim, Vikram Venkatraghavan, Anand J.C. Eijlers, Iman Brouwer, Esther E. Bron, Stefan Klein, Mike P. Wattjes, Alle Meije Wink, Jeroen J.G. Geurts, Bernard M.J. Uitdehaag, Neil P. Oxtoby, Daniel C. Alexander, Hugo Vrenken, Joep Killestein, Frederik Barkhof, Viktor Wottschel
Published in: NeuroImage: Clinical, 29, 2021, Page(s) 102550, ISSN 2213-1582
Publisher: Elsevier BV
DOI: 10.1016/j.nicl.2020.102550
Author(s): Vikram Venkatraghavan, Stefan Klein, Lana Fani, Leontine S. Ham, Henri Vrooman, M. Kamran Ikram, Wiro J. Niessen, Esther E. Bron
Published in: NeuroImage, 227, 2021, Page(s) 117646, ISSN 1053-8119
Publisher: Academic Press
DOI: 10.1016/j.neuroimage.2020.117646
Author(s): I. Koval, J.-B. Schiratti, A. Routier, M. Bacci, O. Colliot, S. Allassonnière, S. Durrleman
Published in: Medical Image Computing and Computer Assisted Intervention − MICCAI 2017, 10433, 2017, Page(s) 451-459, ISBN 978-3-319-66181-0
Publisher: Springer International Publishing
DOI: 10.1007/978-3-319-66182-7_52
Author(s): Alexandre Bône, Maxime Louis, Benoît Martin, Stanley Durrleman
Published in: Shape in Medical Imaging - International Workshop, ShapeMI 2018, Held in Conjunction with MICCAI 2018, Granada, Spain, September 20, 2018, Proceedings, 11167, 2018, Page(s) 3-13, ISBN 978-3-030-04746-7
Publisher: Springer International Publishing
DOI: 10.1007/978-3-030-04747-4_1
Author(s): Răzvan Valentin Marinescu, Arman Eshaghi, Marco Lorenzi, Alexandra L. Young, Neil P. Oxtoby, Sara Garbarino, Timothy J. Shakespeare, Sebastian J. Crutch, Daniel C. Alexander
Published in: Information Processing in Medical Imaging, 10265, 2017, Page(s) 134-145, ISBN 978-3-319-59049-3
Publisher: Springer International Publishing
DOI: 10.1007/978-3-319-59050-9_11
Author(s): Manon Ansart, Stéphane Epelbaum, Geoffroy Gagliardi, Olivier Colliot, Didier Dormont, Bruno Dubois, Harald Hampel, Stanley Durrleman
Published in: Deep Learning in Medical Image Analysis and Multimodal Learning for Clinical Decision Support, 10553, 2017, Page(s) 357-364, ISBN 978-3-319-67557-2
Publisher: Springer International Publishing
DOI: 10.1007/978-3-319-67558-9_41
Author(s): Alexandre Bône, Maxime Louis, Alexandre Routier, Jorge Samper, Michael Bacci, Benjamin Charlier, Olivier Colliot, Stanley Durrleman
Published in: Graphs in Biomedical Image Analysis, Computational Anatomy and Imaging Genetics, 10551, 2017, Page(s) 101-113, ISBN 978-3-319-67674-6
Publisher: Springer International Publishing
DOI: 10.1007/978-3-319-67675-3_10
Author(s): Vikram Venkatraghavan, Esther E. Bron, Wiro J. Niessen, Stefan Klein
Published in: Information Processing in Medical Imaging, 10265, 2017, Page(s) 121-133, ISBN 978-3-319-59049-3
Publisher: Springer International Publishing
DOI: 10.1007/978-3-319-59050-9_10
Author(s): Răzvan V. Marinescu, Neil P. Oxtoby, Alexandra L. Young, Esther E. Bron, Arthur W. Toga, Michael W. Weiner, Frederik Barkhof, Nick C. Fox, Polina Golland, Stefan Klein, Daniel C. Alexander
Published in: Predictive Intelligence in Medicine - Second International Workshop, PRIME 2019, Held in Conjunction with MICCAI 2019, Shenzhen, China, October 13, 2019, Proceedings, 11843, 2019, Page(s) 1-10, ISBN 978-3-030-32280-9
Publisher: Springer International Publishing
DOI: 10.1007/978-3-030-32281-6_1
Author(s): Vikram Venkatraghavan, Florian Dubost, Esther E. Bron, Wiro J. Niessen, Marleen de Bruijne, Stefan Klein
Published in: Information Processing in Medical Imaging - 26th International Conference, IPMI 2019, Hong Kong, China, June 2–7, 2019, Proceedings, 11492, 2019, Page(s) 169-180, ISBN 978-3-030-20350-4
Publisher: Springer International Publishing
DOI: 10.1007/978-3-030-20351-1_13
Author(s): Maxime Louis, Raphaël Couronné, Igor Koval, Benjamin Charlier, Stanley Durrleman
Published in: Information Processing in Medical Imaging - 26th International Conference, IPMI 2019, Hong Kong, China, June 2–7, 2019, Proceedings, 11492, 2019, Page(s) 542-553, ISBN 978-3-030-20350-4
Publisher: Springer International Publishing
DOI: 10.1007/978-3-030-20351-1_42
Author(s): Igor Koval, Alexandre Bône, Maxime Louis, Simona Bottani, Arnaud Marcoux, Jorge Samper-Gonzalez, Ninon Burgos, Benjamin Charlier, Anne Bertrand, Stéphane Epelbaum, Olivier Colliot, Stéphanie Allassonnière, Stanley Durrleman
Published in: 2018
Publisher: Inria