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Polymeric Analogs to Biolubrication Systems

Project description

Mimicking the cartilage-synovial fluid lubrication system with advanced polymers

Nature is often an inspiration for human engineering, be it for industrial or medical applications. The cartilage-synovial fluid system is a complex lubrication system whose tribological properties are unparalleled. Highly confined and hydrated charged polymers play an essential role in the mechanical properties of cartilage. The European Research Council-funded POLYBIOLUB project will attempt to mimic the mechanisms at work in cartilage by synthesising functionally similar polymeric structures via controlled radical polymerisation in a flow environment. Not only is the research expected to shed light on the relationship of structure and function in cartilage, but it could also lead to pioneering biomimetic and naturally lubricated low-wear materials with industrial and clinical applications.

Objective

Lubrication in nature is based on water, but only functions due to the presence of a host of biomolecules. In articular (e.g. hip) joints, it appears that the lubrication system is even more complex than previously believed, involving multiple gradients in structures and properties. Gels and brushes appear to play an important role in biolubrication, while highly confined, highly hydrated charged polymers are key to the important mechanical properties of cartilage. Components such as hyaluronic acid, glycoproteins, and lipids all appear to act synergistically to yield the extraordinary tribological properties of the cartilage-synovial-fluid system. POLYBIOLUB seeks to mimic the mechanisms revealed by the latest studies of cartilage, by means of the synthesis of functionally similar polymeric structures. This is a completely novel approach to the problem, which has the promise not only of revealing structural dependencies of cartilage function, but also of yielding radically new, biomimetic, lubricious, low-wear materials that could find applications in either industrial or clinical environments. The principal synthetic tool will be controlled radical polymerization in a flow environment, involving in situ growth monitoring, followed by a series of postmodification and grafting steps, to yield structures that are lubricious, wear resistant, and tough. These efforts will be accompanied by extensive characterization of composition, structure and mechanical/tribological properties at each stage.

Our group has extensive experience in controlled radical polymerization in a flow system, postmodification of polymers, brush-gel and layered polymer systems,. We also have over a decade of experience in water-based lubrication, natural lubrication, synovial-joint studies, and multidimensional gradient systems. The challenge now is to combine these skills to fabricate a completely new biomimetic material.

Host institution

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Net EU contribution
€ 2 456 570,00
Address
Raemistrasse 101
8092 Zuerich
Switzerland

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Region
Schweiz/Suisse/Svizzera Zürich Zürich
Activity type
Higher or Secondary Education Establishments
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Total cost
€ 2 456 570,00

Beneficiaries (1)