Molecular imaging and targeted therapy of the aggressive phenotype: development of uPAR theranostics for cancer patients

Project Information

uPET

Grant agreement ID: 670261

DOI 10.3030/670261

Project closed

EC signature date 7 September 2015

Start date 1 October 2015

End date 31 March 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 072 000,00

EU contribution € 2 072 000,00

Coordinated by

REGION HOVEDSTADEN
Denmark

Publications

Peer reviewed articles (9)

[68Ga]Ga-NODAGA-E[(cRGDyK)]2 PET and hyperpolarized [1-13C] pyruvate MRSI (hyperPET) in canine cancer patients: simultaneous imaging of angiogenesis and the Warburg effect

Author(s): Andreas Clemmensen, Adam E Hansen, Pernille Holst, Christina Schøier, Sissel Bisgaard, Helle H Johannesen, Jan Henrik Ardenkjær-Larsen, Annemarie T Kristensen, Andreas Kjaer
Published in: European Journal of Nuclear Medicine and Molecular Imaging, Issue 48/2, 2021, Page(s) 395-405, ISSN 1619-7070
Publisher: Springer Verlag
DOI: 10.1007/s00259-020-04881-0

Urokinase-Type Plasminogen Activator Receptor (uPAR) PET/MRI of Prostate Cancer for Noninvasive Evaluation of Aggressiveness: Comparison with Gleason Score in a Prospective Phase 2 Clinical Trial

Author(s): Marie Øbro Fosbøl, Sorel Kurbegovic, Helle Hjorth Johannesen, Martin Andreas Røder, Adam Espe Hansen, Jann Mortensen, Annika Loft, Peter Meidahl Petersen, Jacob Madsen, Klaus Brasso, Andreas Kjaer
Published in: Journal of Nuclear Medicine, Issue 62/3, 2021, Page(s) 354-359, ISSN 0161-5505
Publisher: Kexue Chubaneshe/Science Press
DOI: 10.2967/jnumed.120.248120

Improved surgical resection of metastatic pancreatic cancer using uPAR targeted in vivo fluorescent guidance: comparison with traditional white light surgery

Author(s): Karina Juhl, Anders Christensen, Niclas Rubek, Kirstine Kim Schmidt Karnov, Christian von Buchwald, Andreas Kjaer
Published in: Oncotarget, Issue 10/59, 2019, Page(s) 6308-6316, ISSN 1949-2553
Publisher: Impact Journals
DOI: 10.18632/oncotarget.27220

Combined hyperpolarized 13 C-pyruvate MRS and 18 F-FDG PET (hyperPET) estimates of glycolysis in canine cancer patients

Author(s): Adam E. Hansen, Henrik Gutte, Pernille Holst, Helle H. Johannesen, Sofie Rahbek, Andreas E. Clemmensen, Majbritt M.E. Larsen, Christina Schøier, Jan Ardenkjaer-Larsen, Thomas L. Klausen, Annemarie T. Kristensen, Andreas Kjaer
Published in: European Journal of Radiology, Issue 103, 2018, Page(s) 6-12, ISSN 0720-048X
Publisher: Elsevier BV
DOI: 10.1016/j.ejrad.2018.02.028

Molecular Targeted NIR-II Probe for Image-Guided Brain Tumor Surgery

Author(s): Sorel Kurbegovic, Karina Juhl, Hao Chen, Chunrong Qu, Bingbing Ding, Julie Maja Leth, Krzysztof Tadeusz Drzewiecki, Andreas Kjaer, Zhen Cheng
Published in: Bioconjugate Chemistry, Issue 29/11, 2018, Page(s) 3833-3840, ISSN 1043-1802
Publisher: American Chemical Society
DOI: 10.1021/acs.bioconjchem.8b00669

uPAR-targeted optical near-infrared (NIR) fluorescence imaging and PET for image-guided surgery in head and neck cancer: proof-of-concept in orthotopic xenograft model

Author(s): Christensen A, Juhl K, Persson M, Charabi BW, Mortensen J, Kiss K, Lelkaitis G, Rubek N, von Buchwald C, Kjær A
Published in: Oncotarget, 2017, ISSN 1949-2553
Publisher: Impact Journals
DOI: 10.18632/oncotarget.14282

Simultaneous PET/MRI with 13C magnetic resonance spectroscopic imaging (hyperPET): phantom-based evaluation of PET quantification

Author(s): Adam E. Hansen, Flemming L. Andersen, Sarah T. Henriksen, Alexandre Vignaud, Jan H. Ardenkjaer-Larsen, Liselotte Højgaard, Andreas Kjaer, Thomas L. Klausen
Published in: EJNMMI Physics, Issue 3/1, 2016, Page(s) 7 (13 pages), ISSN 2197-7364
Publisher: Springer Nature
DOI: 10.1186/s40658-016-0143-6

Improved positron emission tomography imaging of glioblastoma cancer using novel 68Ga-labeled peptides targeting the urokinase-type plasminogen activator receptor (uPAR)

Author(s): Loft MD, Sun Y, Liu C, Christensen C, Huang D, Kjaer A, Cheng Z
Published in: Amino Acids, Issue 49(6), 2017, Page(s) 1089-1100, ISSN 1438-2199
Publisher: Springer Vienna
DOI: 10.1007/s00726-017-2407-4

Safety, Dosimetry, and Tumor Detection Ability of 68Ga-NOTA-AE105: First-in-Human Study of a Novel Radioligand for uPAR PET Imaging

Author(s): Skovgaard D, Persson M, Brandt-Larsen M, Christensen C, Madsen J, Klausen TL, Holm S, Andersen FL, Loft A, Berthelsen AK, Pappot H, Brasso K, Kroman N, Højgaard L, Kjaer A
Published in: J Nucl Med, Issue 58(3), 2017, Page(s) 379-386, ISSN 2159-662X
Publisher: Society of Nuclear Medicine and Molecular Imaging
DOI: 10.2967/jnumed.116.178970