Exoribonuclease-mediated degradation of nascent RNA in Malaria Parasites: A Novel Mechanism in Virulence Gene Silencing

Project Information

PlasmoSilencing

Grant agreement ID: 670301

DOI

10.3030/670301

Project closed

EC signature date 12 October 2015

Start date 1 November 2015

End date 31 October 2020

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 499 761,00

EU contribution

€ 2 499 761,00

Coordinated by

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (17)

Exploring the virulence gene interactome with CRISPR / dC as9 in the human malaria parasite

Author(s): Jessica M Bryant, Sebastian Baumgarten, Florent Dingli, Damarys Loew, Ameya Sinha, Aurélie Claës, Peter R Preiser, Peter C Dedon, Artur Scherf
Published in: Molecular Systems Biology, Issue 16/8, 2020, ISSN 1744-4292
Publisher: Nature Publishing Group
DOI: 10.15252/msb.20209569

A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection

Author(s): Gigliola Zanghì, Shruthi S. Vembar, Sebastian Baumgarten, Shuai Ding, Julien Guizetti, Jessica M. Bryant, Denise Mattei, Anja T.R. Jensen, Laurent Rénia, Yun Shan Goh, Robert Sauerwein, Cornelus C. Hermsen, Jean-François Franetich, Mallaury Bordessoulles, Olivier Silvie, Valérie Soulard, Olivier Scatton, Patty Chen, Salah Mecheri, Dominique Mazier, Artur Scherf
Published in: Cell Reports, Issue 22/11, 2018, Page(s) 2951-2963, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2018.02.075

Translational regulation in blood stages of the malaria parasite Plasmodium spp. : systems-wide studies pave the way

Author(s): Shruthi Sridhar Vembar, Dorothea Droll, Artur Scherf
Published in: Wiley Interdisciplinary Reviews: RNA, Issue 7/6, 2016, Page(s) 772-792, ISSN 1757-7004
Publisher: John Wiley and Sons Inc.
DOI: 10.1002/wrna.1365

Complete telomere-to-telomere de novo assembly of the Plasmodium falciparum genome through long-read (>11 kb), single molecule, real-time sequencing

Author(s): Shruthi Sridhar Vembar, Matthew Seetin, Christine Lambert, Maria Nattestad, Michael C. Schatz, Primo Baybayan, Artur Scherf, Melissa Laird Smith
Published in: DNA Research, Issue 23/4, 2016, Page(s) 339-351, ISSN 1340-2838
Publisher: Oxford University Press
DOI: 10.1093/dnares/dsw022

De Novo Genome Assembly of a Plasmodium falciparum NF54 Clone Using Single-Molecule Real-Time Sequencing

Author(s): Jessica M. Bryant, Sebastian Baumgarten, Audrey Lorthiois, Christine Scheidig-Benatar, Aurélie Claës, Artur Scherf
Published in: Genome Announcements, Issue 6/5, 2018, ISSN 2169-8287
Publisher: ASM
DOI: 10.1128/genomeA.01479-17

An ApiAP2 member regulates expression of clonally variant genes of the human malaria parasite Plasmodium falciparum

Author(s): Rafael M. Martins, Cameron R. Macpherson, Aurélie Claes, Christine Scheidig-Benatar, Hiroshi Sakamoto, Xue Yan Yam, Peter Preiser, Suchi Goel, Mats Wahlgren, Odile Sismeiro, Jean-Yves Coppée, Artur Scherf
Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-017-12578-y

Modifications at K31 on the lateral surface of histone H4 contribute to genome structure and expression in apicomplexan parasites

Author(s): Fabien Sindikubwabo, Shuai Ding, Tahir Hussain, Philippe Ortet, Mohamed Barakat, Sebastian Baumgarten, Dominique Cannella, Andrés Palencia, Alexandre Bougdour, Lucid Belmudes, Yohann Couté, Isabelle Tardieux, Cyrille Y Botté, Artur Scherf, Mohamed-ali Hakimi
Published in: eLife, Issue 6, 2017, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/eLife.29391

Trans-acting GC-rich non-coding RNA at var expression site modulates gene counting in malaria parasite

Author(s): Julien Guizetti, Anna Barcons-Simon, Artur Scherf
Published in: Nucleic Acids Research, 2016, Page(s) gkw664, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkw664

CRISPR/Cas9 Genome Editing Reveals That the Intron Is Not Essential for var2csa Gene Activation or Silencing in Plasmodium falciparum

Author(s): Jessica M. Bryant, Clément Regnault, Christine Scheidig-Benatar, Sebastian Baumgarten, Julien Guizetti, Artur Scherf
Published in: mBio, Issue 8/4, 2017, ISSN 2150-7511
Publisher: ASM
DOI: 10.1128/mBio.00729-17

Transcriptome-wide dynamics of extensive m6A mRNA methylation during Plasmodium falciparum blood-stage development

Author(s): Sebastian Baumgarten, Jessica M. Bryant, Ameya Sinha, Thibaud Reyser, Peter R. Preiser, Peter C. Dedon, Artur Scherf
Published in: Nature Microbiology, Issue 4/12, 2019, Page(s) 2246-2259, ISSN 2058-5276
Publisher: Nature
DOI: 10.1038/s41564-019-0521-7

Discovery of a new predominant cytosine DNA modification that is linked to gene expression in malaria parasites

Author(s): Elie Hammam, Guruprasad Ananda, Ameya Sinha, Christine Scheidig-Benatar, Mylene Bohec, Peter R Preiser, Peter C Dedon, Artur Scherf, Shruthi S Vembar
Published in: Nucleic Acids Research, Issue 48/1, 2019, Page(s) 184-199, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkz1093

DNA Methylation Bisubstrate Inhibitors Are Fast-Acting Drugs Active against Artemisinin-Resistant Plasmodium falciparum Parasites

Author(s): Flore Nardella, Ludovic Halby, Elie Hammam, Diane Erdmann, Véronique Cadet-Daniel, Roger Peronet, Didier Ménard, Benoit Witkowski, Salah Mecheri, Artur Scherf, Paola B. Arimondo
Published in: ACS Central Science, Issue 6/1, 2020, Page(s) 16-21, ISSN 2374-7943
Publisher: American Chemical Society
DOI: 10.1021/acscentsci.9b00874

Clipped histone H3 is integrated into nucleosomes of DNA replication genes in the human malaria parasite Plasmodium falciparum

Author(s): Abril Marcela Herrera‐Solorio, Shruthi Sridhar Vembar, Cameron Ross MacPherson, Daniela Lozano‐Amado, Gabriela Romero Meza, Beatriz Xoconostle‐Cazares, Rafael Miyazawa Martins, Patty Chen, Miguel Vargas, Artur Scherf, Rosaura Hernández‐Rivas
Published in: EMBO reports, Issue 20/4, 2019, ISSN 1469-221X
Publisher: Nature Publishing Group
DOI: 10.15252/embr.201846331

Disruption of the RNA exosome reveals the hidden face of the malaria parasite transcriptome

Author(s): Dorothea Droll, Guiying Wei, Gangqiang Guo, Yanting Fan, Sebastian Baumgarten, Yiqing Zhou, Youli Xiao, Artur Scherf, Qingfeng Zhang
Published in: RNA Biology, Issue 15/9, 2018, Page(s) 1206-1214, ISSN 1547-6286
Publisher: Landes Bioscience
DOI: 10.1080/15476286.2018.1517014

Plasmodium falciparum PfSET7: enzymatic characterization and cellular localization of a novel protein methyltransferase in sporozoite, liver and erythrocytic stage parasites

Author(s): Patty B. Chen, Shuai Ding, Gigliola Zanghì, Valérie Soulard, Peter A. DiMaggio, Matthew J. Fuchter, Salah Mecheri, Dominique Mazier, Artur Scherf, Nicholas A. Malmquist
Published in: Scientific Reports, Issue 6/1, 2016, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/srep21802

Laser capture microdissection enables transcriptomic analysis of dividing and quiescent liver stages of Plasmodium relapsing species

Author(s): Roger Cubi, Shruthi S. Vembar, Anne Biton, Jean-Francois Franetich, Mallaury Bordessoulles, Daniel Sossau, Gigliola Zanghi, Henriette Bosson-Vanga, Magalie Benard, Alicia Moreno, Nathalie Dereuddre-Bosquet, Roger Le Grand, Artur Scherf, Dominique Mazier
Published in: Cellular Microbiology, Issue 19/8, 2017, Page(s) e12735, ISSN 1462-5814
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/cmi.12735

CRISPR Interference of a Clonally Variant GC-Rich Noncoding RNA Family Leads to General Repression of var Genes in Plasmodium falciparum

Author(s): Anna Barcons-Simon, Carlos Cordon-Obras, Julien Guizetti, Jessica M. Bryant, Artur Scherf
Published in: mBio, Issue 11/1, 2020, ISSN 2150-7511
Publisher: ASM
DOI: 10.1128/mBio.03054-19