Novel Gene Therapy Based on the Activation of Endogenous Genes for the Treatment of Ischemia - Concepts of endogenetherapy, release of promoter pausing, promoter-targeted ncRNAs and nuclear RNAi

Project Information

CleverGenes

Grant agreement ID: 670951

DOI 10.3030/670951

Project closed

EC signature date 27 October 2015

Start date 1 November 2015

End date 30 April 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 437 500,00

EU contribution € 2 437 500,00

Coordinated by

ITA-SUOMEN YLIOPISTO
Finland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (16)

Efficient Nuclease-Directed Integration of Lentivirus Vectors into the Human Ribosomal DNA Locus

Author(s): Diana Schenkwein, Saira Afzal, Alisa Nousiainen, Manfred Schmidt, Seppo Ylä-Herttuala
Published in: Molecular Therapy, Issue 28/8, 2020, Page(s) 1858-1875, ISSN 1525-0016
Publisher: Nature Publishing Group
DOI: 10.1016/j.ymthe.2020.05.019

Deletion of Lymphangiogenic and Angiogenic Growth Factor VEGF-D Leads to Severe Hyperlipidemia and Delayed Clearance of Chylomicron Remnants

Author(s): Annakaisa Tirronen, Taina Vuorio, Sanna Kettunen, Krista Hokkanen, Bastian Ramms, Henri Niskanen, Hanne Laakso, Minna U. Kaikkonen, Matti Jauhiainen, Philip L.S.M. Gordts, Seppo Ylä-Herttuala
Published in: Arteriosclerosis, Thrombosis, and Vascular Biology, Issue 38/10, 2018, Page(s) 2327-2337, ISSN 1079-5642
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.118.311549

Doxycycline modulates VEGF-A expression: Failure of doxycycline-inducible lentivirus shRNA vector to knockdown VEGF-A expression in transgenic mice

Author(s): Mari Merentie, Riina Rissanen, Line Lottonen-Raikaslehto, Jenni Huusko, Erika Gurzeler, Mikko P. Turunen, Lari Holappa, Petri Mäkinen, Seppo Ylä-Herttuala
Published in: PLOS ONE, Issue 13/1, 2018, Page(s) e0190981, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0190981

Susceptibility to Cardiac Arrhythmias and Sympathetic Nerve Growth in VEGF-B Overexpressing Myocardium

Author(s): Johanna Lähteenvuo, Olli-Pekka Hätinen, Antti Kuivanen, Jenni Huusko, Jussi Paananen, Markku Lähteenvuo, Jussi Nurro, Marja Hedman, Juha Hartikainen, Nihay Laham-Karam, Petri Mäkinen, Markus Räsänen, Kari Alitalo, Anthony Rosenzweig, Seppo Ylä-Herttuala
Published in: Molecular Therapy, Issue 28/7, 2020, Page(s) 1731-1740, ISSN 1525-0016
Publisher: Nature Publishing Group
DOI: 10.1016/j.ymthe.2020.03.011

Adenoviral Gene Transfer of Gremlin Modulates Vascular Endothelial Growth Factor-A-Induced Angiogenesis in Porcine Myocardium

Author(s): Juho J. Pajula, Paavo J. Halonen, Olli-Pekka Hätinen, Seppo Ylä-Herttuala, Jussi Nurro
Published in: Human Gene Therapy, Issue 31/3-4, 2020, Page(s) 211-218, ISSN 1043-0342
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/hum.2019.229

Advances and Challenges in Cardiovascular Gene Therapy

Author(s): Johanna Lähteenvuo, Seppo Ylä-Herttuala
Published in: Human Gene Therapy, Issue 28/11, 2017, Page(s) 1024-1032, ISSN 1043-0342
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/hum.2017.129

Activating the Chromatin by Noncoding RNAs

Author(s): Nihay Laham-Karam, Pia Laitinen, Tiia A. Turunen, Seppo Ylä-Herttuala
Published in: Antioxidants & Redox Signaling, 2012, ISSN 1523-0864
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/ars.2017.7248

Differential regulation of angiogenic cellular processes and claudin-5 by histamine and VEGF via PI3K-signaling, transcription factor SNAI2 and interleukin-8

Author(s): Johanna P. Laakkonen, Jari P. Lappalainen, Thomas L. Theelen, Pyry I. Toivanen, Tiina Nieminen, Suvi Jauhiainen, Minna U. Kaikkonen, Judith C. Sluimer, Seppo Ylä-Herttuala
Published in: Angiogenesis, Issue 20/1, 2017, Page(s) 109-124, ISSN 0969-6970
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10456-016-9532-7

Intramyocardial Gene Therapy Directed to Hibernating Heart Muscle Using a Combination of Electromechanical Mapping and Positron Emission Tomography

Author(s): Iiro Hassinen, Antti Kivelä, Antti Hedman, Antti Saraste, Juhani Knuuti, Juha Hartikainen, Seppo Ylä-Herttuala
Published in: Human Gene Therapy, Issue 27/10, 2016, Page(s) 830-834, ISSN 1043-0342
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/hum.2016.131

AdVEGF-B 186 and AdVEGF-D ΔNΔC induce angiogenesis and increase perfusion in porcine myocardium

Author(s): Jussi Nurro, Paavo J Halonen, Antti Kuivanen, Miikka Tarkia, Antti Saraste, Krista Honkonen, Johanna Lähteenvuo, Tuomas T Rissanen, Juhani Knuuti, Seppo Ylä-Herttuala
Published in: Heart, Issue 102/21, 2016, Page(s) 1716-1720, ISSN 1355-6037
Publisher: BMJ Publishing Group
DOI: 10.1136/heartjnl-2016-309373

Endothelial cell differentiation is encompassed by changes in long range interactions between inactive chromatin regions

Author(s): Henri Niskanen, Irina Tuszynska, Rafal Zaborowski, Merja Heinäniemi, Seppo Ylä-Herttuala, Bartek Wilczynski, Minna U Kaikkonen
Published in: Nucleic Acids Research, Issue 46/4, 2017, Page(s) 1724-1740, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkx1214

Genome-Wide Dynamics of Nascent Noncoding RNA Transcription in Porcine Heart After Myocardial InfarctionCLINICAL PERSPECTIVE

Author(s): Minna U. Kaikkonen, Paavo Halonen, Oscar Hsin-Fu Liu, Tiia A. Turunen, Juho Pajula, Pierre Moreau, Ilakya Selvarajan, Tomi Tuomainen, Einari Aavik, Pasi Tavi, Seppo Ylä-Herttuala
Published in: Circulation: Cardiovascular Genetics, Issue 10/3, 2017, Page(s) e001702, ISSN 1942-3268
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCGENETICS.117.001702

Cardiovascular Gene Therapy: Past, Present, and Future

Author(s): Seppo Ylä-Herttuala, Andrew H. Baker
Published in: Molecular Therapy, Issue 25/5, 2017, Page(s) 1095-1106, ISSN 1525-0016
Publisher: Nature Publishing Group
DOI: 10.1016/j.ymthe.2017.03.027

Downregulation of VEGFR3 signaling alters cardiac lymphatic vessel organization and leads to a higher mortality after acute myocardial infarction

Author(s): Taina Vuorio, Elias Ylä-Herttuala, Johanna P. Laakkonen, Svetlana Laidinen, Timo Liimatainen, Seppo Ylä-Herttuala
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-34770-4

Differential but Complementary HIF1α and HIF2α Transcriptional Regulation

Author(s): Nicholas L. Downes, Nihay Laham-Karam, Minna U. Kaikkonen, Seppo Ylä-Herttuala
Published in: Molecular Therapy, Issue 26/7, 2018, Page(s) 1735-1745, ISSN 1525-0016
Publisher: Nature Publishing Group
DOI: 10.1016/j.ymthe.2018.05.004

Axon Guidance-Related Factor FLRT3 Regulates VEGF-Signaling and Endothelial Cell Function

Author(s): Suvi Jauhiainen, Johanna P. Laakkonen, Kirsi Ketola, Pyry I. Toivanen, Tiina Nieminen, Takeshi Ninchoji, Anna-Liisa Levonen, Minna U. Kaikkonen, Seppo Ylä-Herttuala
Published in: Frontiers in Physiology, Issue 10, 2019, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2019.00224