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Novel Gene Therapy Based on the Activation of Endogenous Genes for the Treatment of Ischemia - Concepts of endogenetherapy, release of promoter pausing, promoter-targeted ncRNAs and nuclear RNAi

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Publications

Advances and Challenges in Cardiovascular Gene Therapy

Author(s): Johanna Lähteenvuo, Seppo Ylä-Herttuala
Published in: Human Gene Therapy, Issue 28/11, 2017, Page(s) 1024-1032, ISSN 1043-0342
DOI: 10.1089/hum.2017.129

Activating the Chromatin by Noncoding RNAs

Author(s): Nihay Laham-Karam, Pia Laitinen, Tiia A. Turunen, Seppo Ylä-Herttuala
Published in: Antioxidants & Redox Signaling, 2012, ISSN 1523-0864
DOI: 10.1089/ars.2017.7248

Differential regulation of angiogenic cellular processes and claudin-5 by histamine and VEGF via PI3K-signaling, transcription factor SNAI2 and interleukin-8

Author(s): Johanna P. Laakkonen, Jari P. Lappalainen, Thomas L. Theelen, Pyry I. Toivanen, Tiina Nieminen, Suvi Jauhiainen, Minna U. Kaikkonen, Judith C. Sluimer, Seppo Ylä-Herttuala
Published in: Angiogenesis, Issue 20/1, 2017, Page(s) 109-124, ISSN 0969-6970
DOI: 10.1007/s10456-016-9532-7

Intramyocardial Gene Therapy Directed to Hibernating Heart Muscle Using a Combination of Electromechanical Mapping and Positron Emission Tomography

Author(s): Iiro Hassinen, Antti Kivelä, Antti Hedman, Antti Saraste, Juhani Knuuti, Juha Hartikainen, Seppo Ylä-Herttuala
Published in: Human Gene Therapy, Issue 27/10, 2016, Page(s) 830-834, ISSN 1043-0342
DOI: 10.1089/hum.2016.131

AdVEGF-B 186 and AdVEGF-D ΔNΔC induce angiogenesis and increase perfusion in porcine myocardium

Author(s): Jussi Nurro, Paavo J Halonen, Antti Kuivanen, Miikka Tarkia, Antti Saraste, Krista Honkonen, Johanna Lähteenvuo, Tuomas T Rissanen, Juhani Knuuti, Seppo Ylä-Herttuala
Published in: Heart, Issue 102/21, 2016, Page(s) 1716-1720, ISSN 1355-6037
DOI: 10.1136/heartjnl-2016-309373

Endothelial cell differentiation is encompassed by changes in long range interactions between inactive chromatin regions

Author(s): Henri Niskanen, Irina Tuszynska, Rafal Zaborowski, Merja Heinäniemi, Seppo Ylä-Herttuala, Bartek Wilczynski, Minna U Kaikkonen
Published in: Nucleic Acids Research, Issue 46/4, 2017, Page(s) 1724-1740, ISSN 0305-1048
DOI: 10.1093/nar/gkx1214

Genome-Wide Dynamics of Nascent Noncoding RNA Transcription in Porcine Heart After Myocardial InfarctionCLINICAL PERSPECTIVE

Author(s): Minna U. Kaikkonen, Paavo Halonen, Oscar Hsin-Fu Liu, Tiia A. Turunen, Juho Pajula, Pierre Moreau, Ilakya Selvarajan, Tomi Tuomainen, Einari Aavik, Pasi Tavi, Seppo Ylä-Herttuala
Published in: Circulation: Cardiovascular Genetics, Issue 10/3, 2017, Page(s) e001702, ISSN 1942-3268
DOI: 10.1161/CIRCGENETICS.117.001702

Cardiovascular Gene Therapy: Past, Present, and Future

Author(s): Seppo Ylä-Herttuala, Andrew H. Baker
Published in: Molecular Therapy, Issue 25/5, 2017, Page(s) 1095-1106, ISSN 1525-0016
DOI: 10.1016/j.ymthe.2017.03.027