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Novel Gene Therapy Based on the Activation of Endogenous Genes for the Treatment of Ischemia - Concepts of endogenetherapy, release of promoter pausing, promoter-targeted ncRNAs and nuclear RNAi

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Publications

Efficient Nuclease-Directed Integration of Lentivirus Vectors into the Human Ribosomal DNA Locus

Author(s): Diana Schenkwein, Saira Afzal, Alisa Nousiainen, Manfred Schmidt, Seppo Ylä-Herttuala
Published in: Molecular Therapy, 28/8, 2020, Page(s) 1858-1875, ISSN 1525-0016
Publisher: Nature Publishing Group
DOI: 10.1016/j.ymthe.2020.05.019

Deletion of Lymphangiogenic and Angiogenic Growth Factor VEGF-D Leads to Severe Hyperlipidemia and Delayed Clearance of Chylomicron Remnants

Author(s): Annakaisa Tirronen, Taina Vuorio, Sanna Kettunen, Krista Hokkanen, Bastian Ramms, Henri Niskanen, Hanne Laakso, Minna U. Kaikkonen, Matti Jauhiainen, Philip L.S.M. Gordts, Seppo Ylä-Herttuala
Published in: Arteriosclerosis, Thrombosis, and Vascular Biology, 38/10, 2018, Page(s) 2327-2337, ISSN 1079-5642
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.118.311549

Doxycycline modulates VEGF-A expression: Failure of doxycycline-inducible lentivirus shRNA vector to knockdown VEGF-A expression in transgenic mice

Author(s): Mari Merentie, Riina Rissanen, Line Lottonen-Raikaslehto, Jenni Huusko, Erika Gurzeler, Mikko P. Turunen, Lari Holappa, Petri Mäkinen, Seppo Ylä-Herttuala
Published in: PLOS ONE, 13/1, 2018, Page(s) e0190981, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0190981

Susceptibility to Cardiac Arrhythmias and Sympathetic Nerve Growth in VEGF-B Overexpressing Myocardium

Author(s): Johanna Lähteenvuo, Olli-Pekka Hätinen, Antti Kuivanen, Jenni Huusko, Jussi Paananen, Markku Lähteenvuo, Jussi Nurro, Marja Hedman, Juha Hartikainen, Nihay Laham-Karam, Petri Mäkinen, Markus Räsänen, Kari Alitalo, Anthony Rosenzweig, Seppo Ylä-Herttuala
Published in: Molecular Therapy, 28/7, 2020, Page(s) 1731-1740, ISSN 1525-0016
Publisher: Nature Publishing Group
DOI: 10.1016/j.ymthe.2020.03.011

Adenoviral Gene Transfer of Gremlin Modulates Vascular Endothelial Growth Factor-A-Induced Angiogenesis in Porcine Myocardium

Author(s): Juho J. Pajula, Paavo J. Halonen, Olli-Pekka Hätinen, Seppo Ylä-Herttuala, Jussi Nurro
Published in: Human Gene Therapy, 31/3-4, 2020, Page(s) 211-218, ISSN 1043-0342
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/hum.2019.229

Advances and Challenges in Cardiovascular Gene Therapy

Author(s): Johanna Lähteenvuo, Seppo Ylä-Herttuala
Published in: Human Gene Therapy, 28/11, 2017, Page(s) 1024-1032, ISSN 1043-0342
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/hum.2017.129

Activating the Chromatin by Noncoding RNAs

Author(s): Nihay Laham-Karam, Pia Laitinen, Tiia A. Turunen, Seppo Ylä-Herttuala
Published in: Antioxidants & Redox Signaling, 2012, ISSN 1523-0864
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/ars.2017.7248

Differential regulation of angiogenic cellular processes and claudin-5 by histamine and VEGF via PI3K-signaling, transcription factor SNAI2 and interleukin-8

Author(s): Johanna P. Laakkonen, Jari P. Lappalainen, Thomas L. Theelen, Pyry I. Toivanen, Tiina Nieminen, Suvi Jauhiainen, Minna U. Kaikkonen, Judith C. Sluimer, Seppo Ylä-Herttuala
Published in: Angiogenesis, 20/1, 2017, Page(s) 109-124, ISSN 0969-6970
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10456-016-9532-7

Intramyocardial Gene Therapy Directed to Hibernating Heart Muscle Using a Combination of Electromechanical Mapping and Positron Emission Tomography

Author(s): Iiro Hassinen, Antti Kivelä, Antti Hedman, Antti Saraste, Juhani Knuuti, Juha Hartikainen, Seppo Ylä-Herttuala
Published in: Human Gene Therapy, 27/10, 2016, Page(s) 830-834, ISSN 1043-0342
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/hum.2016.131

AdVEGF-B 186 and AdVEGF-D ΔNΔC induce angiogenesis and increase perfusion in porcine myocardium

Author(s): Jussi Nurro, Paavo J Halonen, Antti Kuivanen, Miikka Tarkia, Antti Saraste, Krista Honkonen, Johanna Lähteenvuo, Tuomas T Rissanen, Juhani Knuuti, Seppo Ylä-Herttuala
Published in: Heart, 102/21, 2016, Page(s) 1716-1720, ISSN 1355-6037
Publisher: BMJ Publishing Group
DOI: 10.1136/heartjnl-2016-309373

Endothelial cell differentiation is encompassed by changes in long range interactions between inactive chromatin regions

Author(s): Henri Niskanen, Irina Tuszynska, Rafal Zaborowski, Merja Heinäniemi, Seppo Ylä-Herttuala, Bartek Wilczynski, Minna U Kaikkonen
Published in: Nucleic Acids Research, 46/4, 2017, Page(s) 1724-1740, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkx1214

Genome-Wide Dynamics of Nascent Noncoding RNA Transcription in Porcine Heart After Myocardial InfarctionCLINICAL PERSPECTIVE

Author(s): Minna U. Kaikkonen, Paavo Halonen, Oscar Hsin-Fu Liu, Tiia A. Turunen, Juho Pajula, Pierre Moreau, Ilakya Selvarajan, Tomi Tuomainen, Einari Aavik, Pasi Tavi, Seppo Ylä-Herttuala
Published in: Circulation: Cardiovascular Genetics, 10/3, 2017, Page(s) e001702, ISSN 1942-3268
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCGENETICS.117.001702

Cardiovascular Gene Therapy: Past, Present, and Future

Author(s): Seppo Ylä-Herttuala, Andrew H. Baker
Published in: Molecular Therapy, 25/5, 2017, Page(s) 1095-1106, ISSN 1525-0016
Publisher: Nature Publishing Group
DOI: 10.1016/j.ymthe.2017.03.027

Downregulation of VEGFR3 signaling alters cardiac lymphatic vessel organization and leads to a higher mortality after acute myocardial infarction

Author(s): Taina Vuorio, Elias Ylä-Herttuala, Johanna P. Laakkonen, Svetlana Laidinen, Timo Liimatainen, Seppo Ylä-Herttuala
Published in: Scientific Reports, 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-34770-4

Differential but Complementary HIF1α and HIF2α Transcriptional Regulation

Author(s): Nicholas L. Downes, Nihay Laham-Karam, Minna U. Kaikkonen, Seppo Ylä-Herttuala
Published in: Molecular Therapy, 26/7, 2018, Page(s) 1735-1745, ISSN 1525-0016
Publisher: Nature Publishing Group
DOI: 10.1016/j.ymthe.2018.05.004

Axon Guidance-Related Factor FLRT3 Regulates VEGF-Signaling and Endothelial Cell Function

Author(s): Suvi Jauhiainen, Johanna P. Laakkonen, Kirsi Ketola, Pyry I. Toivanen, Tiina Nieminen, Takeshi Ninchoji, Anna-Liisa Levonen, Minna U. Kaikkonen, Seppo Ylä-Herttuala
Published in: Frontiers in Physiology, 10, 2019, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2019.00224