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Mimicking organs on chips for high throughput drug screening and basic research

Objective

MIMIC is an interdisciplinary European Industrial Doctorate at the interface of cell biology, engineering and drug development. MIMIC aims to develop and improve novel “organs on chips” technology. This technology combines modern cell biology with microfluidics and chip-based techniques with the goal to mimic organ functionality. There is a high demand by the pharmaceutical industry for more reliable tissue models to test drug toxicity and drug efficiency at early stages of drug development. Early reliable drug testing will have a major impact on drug development costs and human health. Furthermore, ethical considerations urge for the search for alternatives to replace animal tests in drug development and basic research. Organs on chips are a new exciting possibility to closer mimic human organ functionality in vitro than conventional 2D or 3D cell cultures.
Organs on chips allow both, the emulation of healthy organs as well as the emulation of specific disease conditions using corresponding engineered or patient derived human cells. Moreover, organs on chips are ideally suited for high-throughput drug screening. The EID-MIMIC will develop novel organs on chips prototypes, and validate their suitability for end-users for high throughput drug screening or basic research. MIMIC will train early stage researchers in cutting edge technologies, like novel chip based technologies e.g. cell micropatterning, soft-lithography and microfluidics technology, as well as state of the art microscopy like super resolution- and confocal spinning disc microscopy and modern genome editing techniques like CRISPR-technology. In addition, MIMIC has developed a 3 year modular curriculum including workshops on creativity and business skills, summer schools, business plan competitions and international conferences with a specific agenda of transferable skill training elements highly relevant for scientific communication, translational research and, in particular, entrepreneurship.

Field of science

  • /natural sciences/biological sciences/cell biology
  • /social sciences/economics and business
  • /social sciences/economics and business/business and management/entrepreneurship
  • /natural sciences/biological sciences/genetics and heredity/genome

Call for proposal

H2020-MSCA-ITN-2015
See other projects for this call

Funding Scheme

MSCA-ITN-EID - European Industrial Doctorates

Coordinator

THE UNIVERSITY OF SHEFFIELD
Address
Firth Court Western Bank
S10 2TN Sheffield
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 546 575,76

Participants (2)

MIMETAS BV
Netherlands
EU contribution
€ 255 374,28
Address
Jh Oortweg 19
2333CH Leiden
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
GALAPAGOS BV
Netherlands
EU contribution
€ 255 374,28
Address
Darwinweg 24
2333CR Leiden
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)

Partners (2)

INSTITUT CURIE
France
Address
Rue D'ulm 26
75231 Paris
Activity type
Research Organisations
Biotechnology Yes
United Kingdom
Address
University Park
NG7 2RD Nottingham
Activity type
Higher or Secondary Education Establishments