Periodic Reporting for period 2 - PANINI (Physical Activity and Nutrition INfluences In ageing)
Reporting period: 2018-01-01 to 2019-12-31
Across PANINI it was possible to combine and share datasets and test key markers of ageing, and model the contribution of factors such as genetics and muscle metabolomics to muscle function, frailty and survival. PANINI researchers have studied in detail the predictors of different measures of health and wellbeing among middle-aged and older people including hormones, muscle strength and function, genetics, and stress. The biological mechanisms have been investigated including how these factors interact with nutrition choices and physical activity engagement. PANINI has also explored the factors predicting knowledge and choice of different dietary and physical activity advice, providing vital information regarding the potential targets for intervention and policy guidance. Finally, PANINI has developed and tested nutritional and physical activity interventions in a range of settings and older adult populations in terms of their impact on cognitive, psychological, social, and physical function measures, leading to conclusions regarding the feasibility of such interventions as well as the impact of intervention adherence. The PANINI project has been addressing the impact of physical activity and nutrition on healthy ageing from diverse but interlinked perspectives. It emphasises the importance of using standardized measures and the advantages of combining data to compare biomarkers and interventions across different settings and typologies of older adults. As the projects conclude, the current results and final data will form part of a shared dataset, which will be made open access for other researchers into ageing processes.
The PANINI project is filling a key knowledge gap by considering the impact of lifestyle factors on healthy ageing and disease, specifically physical activity and nutrition. These factors and their influence on various bodily systems and the net effect on the individual should not be considered in isolation. Consequently, the PANINI project is an innovative multi-disciplinary training and research network examining the influence of physical activity and nutrition on age-related changes from gene to societal level. As a result, PANINI is very diverse in the nature of research conducted. However, it devised a toolkit of multi-factorial important measures of physical activity, nutrition, physical function and wellbeing in ageing using existing gold standards and/or previously validated and commonly used measures across existing datasets. This means that each project, as far as was possible, has integrated the measurement of a standard set or part of a standard set of measures for comparison across populations in addition to answering their own specific research questions.
• Enhancing research and innovation-related human resources, skills, and working conditions to realise the potential of individuals and to provide new career perspectives
• Key Skills, Career Prospects, Employability
• Fostering Creativity and Entrepreneurial Skills
• Contribution of the non-academic sector to the doctoral research training, as appropriate to the implementation mode and research
• Effectiveness of the proposed communication and dissemination of results
• Communication and public engagement strategy of the project
• Dissemination of the research results:
• Exploitation of results and intellectual property (IP)
To meet these impact goals we ensured that our ESRs were trained in complementary skills as well as specific and generic research skills at the individual beneficiary sites as well as through the ATCs and secondments. ATCs were developed to offer careers advice, enhance employability and entrepreneurship as well as increasing their ability to organise a conference. The group and lab secondments involved our non-academic partners in training and secondments, giving them access and experience in a range of different settings. PANINI have continued to exploit our research through its articles, community based research and event presentations. The ESRs have received formal and informal training that will enhance their CVs to make them more employable in academia and industry.