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Principles of Polarity – Integrating genetic, biophysical and computational approaches to understand cell and tissue polarity

Objective

The ability of cells to polarize underlies the most basic biological functions such as motility and response to external challenges, but also the formation and maintenance of tissues in a multicellular organism. The importance of cell polarity is underscored by the fact that cell polarity is essential for animal development and is perturbed in disease states such as cancer. Understanding cell polarity requires knowledge of the molecular players involved and a quantitative description of their biochemical interactions, as well as the mechanical processes underlying polarity establishment. PolarNet brings together academic and private partners from 7 European countries to establish a multidisciplinary, intersectoral training and research programme that will study the basic principles of cell polarity. The research will combine complementary model systems ranging from fungi and cultured mammalian cells to whole organisms, and employ a broad set of approaches such as advanced genetics, protein biochemistry, high-resolution live imaging and image analysis, biophysics and theoretical modelling. This setting provides an opportunity to train early stage researchers in a unique combination of experimental and theoretical approaches. This will provide an excellent starting point for a successful career in the rapidly expanding field of multidisciplinary or ‘integrative’ biology. Training Europe’s next generation of scientists at the forefront of cell and organismal polarity research is crucial for progress in several medically important fields, including cancer research and stem cell biology. The tight collaboration with non-academic partners will strengthen the technological base of different projects and provide early stage researchers with insights into the translation potential of the performed studies and the career development opportunities in biomedical industry.

Field of science

  • /natural sciences/biological sciences/cell biology
  • /medical and health sciences/medical biotechnology/cells technologies/stem cells
  • /natural sciences/biological sciences/cell biology/cell polarity
  • /natural sciences/biological sciences/genetics and heredity
  • /natural sciences/biological sciences/microbiology/mycology
  • /natural sciences/biological sciences/microbiology/mycology/ethnomycology
  • /natural sciences/biological sciences/biophysics
  • /natural sciences/biological sciences/biochemistry
  • /medical and health sciences/clinical medicine/oncology/cancer

Call for proposal

H2020-MSCA-ITN-2015
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

UNIVERSITEIT UTRECHT
Address
Heidelberglaan 8
3584 CS Utrecht
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 276 871,40

Participants (8)

TECHNISCHE UNIVERSITAET DRESDEN
Germany
EU contribution
€ 249 216,48
Address
Helmholtzstrasse 10
01069 Dresden
Activity type
Higher or Secondary Education Establishments
INSTITUT CURIE
France
EU contribution
€ 262 875,60
Address
Rue D'ulm 26
75231 Paris
Activity type
Research Organisations
THE FRANCIS CRICK INSTITUTE LIMITED
United Kingdom
EU contribution
€ 273 287,88
Address
1 Midland Road
NW1 1AT London
Activity type
Research Organisations
CARDIFF UNIVERSITY
United Kingdom
EU contribution
€ 546 575,76
Address
Newport Road 30-36
CF24 ODE Cardiff
Activity type
Higher or Secondary Education Establishments
UNIVERSITY COLLEGE LONDON
United Kingdom
EU contribution
€ 273 287,88
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
INSTITUT PASTEUR
France
EU contribution
€ 525 751,20
Address
Rue Du Docteur Roux 25-28
75724 Paris Cedex 15
Activity type
Research Organisations
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 262 875,60
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
UNIVERSITAT BASEL
Switzerland
EU contribution
€ 265 226,76
Address
Petersplatz 1
4051 Basel
Activity type
Higher or Secondary Education Establishments

Partners (4)

ELEVATE BV
Netherlands
Address
Heidelberglaan 8
3584 CS Utrecht
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
NDS Ltd.
United Kingdom
Address
8Th Floor Eastgate House
CF240AB Cardiff
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Union Biometrica BVBA
Belgium
Address
Cipalstraat 3
2440 Geel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Scientific Volume Imaging BV
Netherlands
Address
Laapersveld 63
1213 VB Hilversum
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)