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Principles of Polarity – Integrating genetic, biophysical and computational approaches to understand cell and tissue polarity

Objective

The ability of cells to polarize underlies the most basic biological functions such as motility and response to external challenges, but also the formation and maintenance of tissues in a multicellular organism. The importance of cell polarity is underscored by the fact that cell polarity is essential for animal development and is perturbed in disease states such as cancer. Understanding cell polarity requires knowledge of the molecular players involved and a quantitative description of their biochemical interactions, as well as the mechanical processes underlying polarity establishment. PolarNet brings together academic and private partners from 7 European countries to establish a multidisciplinary, intersectoral training and research programme that will study the basic principles of cell polarity. The research will combine complementary model systems ranging from fungi and cultured mammalian cells to whole organisms, and employ a broad set of approaches such as advanced genetics, protein biochemistry, high-resolution live imaging and image analysis, biophysics and theoretical modelling. This setting provides an opportunity to train early stage researchers in a unique combination of experimental and theoretical approaches. This will provide an excellent starting point for a successful career in the rapidly expanding field of multidisciplinary or ‘integrative’ biology. Training Europe’s next generation of scientists at the forefront of cell and organismal polarity research is crucial for progress in several medically important fields, including cancer research and stem cell biology. The tight collaboration with non-academic partners will strengthen the technological base of different projects and provide early stage researchers with insights into the translation potential of the performed studies and the career development opportunities in biomedical industry.

Coordinator

UNIVERSITEIT UTRECHT
Net EU contribution
€ 1 276 871,40
Address
Heidelberglaan 8
3584 CS Utrecht
Netherlands

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Region
West-Nederland Utrecht Utrecht
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00

Participants (8)

TECHNISCHE UNIVERSITAET DRESDEN
Germany
Net EU contribution
€ 249 216,48
Address
Helmholtzstrasse 10
01069 Dresden

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Region
Sachsen Dresden Dresden, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
INSTITUT CURIE
France
Net EU contribution
€ 262 875,60
Address
Rue D Ulm 26
75231 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 0,00
THE FRANCIS CRICK INSTITUTE LIMITED
United Kingdom
Net EU contribution
€ 273 287,88
Address
1 Midland Road
NW1 1AT London

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Region
London Inner London — West Camden and City of London
Activity type
Research Organisations
Other funding
€ 0,00
CARDIFF UNIVERSITY
United Kingdom
Net EU contribution
€ 546 575,76
Address
Newport Road 30 36
CF24 0DE Cardiff

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Region
Wales East Wales Cardiff and Vale of Glamorgan
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
UNIVERSITY COLLEGE LONDON
United Kingdom
Net EU contribution
€ 273 287,88
Address
Gower Street
WC1E 6BT London

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Region
London Inner London — West Camden and City of London
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
INSTITUT PASTEUR
France
Net EU contribution
€ 525 751,20
Address
Rue Du Docteur Roux 25-28
75724 Paris Cedex 15

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 0,00
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
Net EU contribution
€ 262 875,60
Address
Rue Michel Ange 3
75794 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 0,00
UNIVERSITAT BASEL
Switzerland
Net EU contribution
€ 265 226,76
Address
Petersplatz 1
4051 Basel

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Region
Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00

Partners (4)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

ELEVATE BV
Netherlands
Net EU contribution
€ 0,00
Address
Newtonlaan 203
3584 BH Utrecht

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
West-Nederland Utrecht Utrecht
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

NDS Ltd.
United Kingdom
Net EU contribution
€ 0,00
Address
8th Floor Eastgate House
CF240AB Cardiff

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Region
Wales East Wales Cardiff and Vale of Glamorgan
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

Union Biometrica BVBA
Belgium
Net EU contribution
€ 0,00
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

Scientific Volume Imaging BV
Netherlands
Net EU contribution
€ 0,00
Address
Laapersveld 63
1213 VB Hilversum

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Region
West-Nederland Noord-Holland Het Gooi en Vechtstreek
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00