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Integration of herpesvirus into telomeres: From the mechanism of genome integration and mobilization to therapeutic intervention

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Publications

Left-handed DNA-PAINT for improved superresolution imaging in the nucleus.

Author(s): Hylkje Geertsema; Giulia Aimola; Valentin Fabricius; Jens Peter Fuerste; Benedikt B. Kaufer; Helge Ewers
Published in: Nature Biotechnology, 1, 2021, ISSN 1087-0156
Publisher: Nature Publishing Group
DOI: 10.1101/2020.03.28.010553

Unbiased optical mapping of telomere-integrated endogenous human herpesvirus 6

Author(s): Darren J. Wight; Giulia Aimola; Amr Aswad; Chi-Yu Jill Lai; Christian Bahamon; Karl Hong; Joshua A. Hill; Benedikt B. Kaufer
Published in: PNAS, 117 (49), 2022, Page(s) 31410-31416, ISSN 1091-6490
Publisher: National Academy of Science
DOI: 10.1073/pnas.2011872117

A Cell Culture System to Investigate Marek’s Disease Virus Integration into Host Chromosomes

Author(s): Yu You; Tereza Vychodil; Giulia Aimola; Renato L Previdelli; Thomas W. Göbel; Luca D. Bertzbach; Benedikt B. Kaufer
Published in: Microorganisms, Vol 9, Iss 2489, p 2489 (2021), 1, 2022, ISSN 2076-2607
Publisher: MDPI
DOI: 10.3390/microorganisms9122489

Selective inhibition of miRNA processing by a herpesvirus-encoded miRNA

Author(s): Thomas Hennig, Archana B. Prusty, Benedikt B. Kaufer, Adam W. Whisnant, Manivel Lodha, Antje Enders, Julius Thomas, Francesca Kasimir, Arnhild Grothey, Teresa Klein, Stefanie Herb, Christopher Jürges, Markus Sauer, Utz Fischer, Thomas Rudel, Gunter Meister, Florian Erhard, Lars Dölken & Bhupesh K. Prusty
Published in: Nature, Nature, 04 May 2022, 2022, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-04667-4

Visualization of Marek’s Disease Virus Genomes in Living Cells during Lytic Replication and Latency

Author(s): Tereza Vychodil, Darren J. Wight, Mariana Nascimento, Fabian Jolmes, Thomas Korte, Andreas Herrmann and Benedikt B. Kaufer
Published in: Viruses, 2022, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v14020287

Evolutionary history of endogenous Human Herpesvirus 6 reflects human migration out of Africa

Author(s): Amr Aswad, Giulia Aimola, Darren Wight, Pavitra Roychoudhury, Cosima Zimmermann, Joshua Hill, Dirk Lassner, Hong Xie, Meei-Li Huang, Nicholas F Parrish, Heinz-Peter Schultheiss, Cristina Venturini, Susanne Lager, Gordon C S Smith, D Stephen Charnock-Jones, Judith Breuer, Alexander L Greninger, Benedikt B Kaufer
Published in: Molecular Biology and Evolution, msaa190, 2020, Page(s) 190, ISSN 0737-4038
Publisher: Oxford University Press
DOI: 10.1093/molbev/msaa190

The ND10 Complex Represses Lytic Human Herpesvirus 6A Replication and Promotes Silencing of the Viral Genome

Author(s): Anirban Sanyal, Nina Wallaschek, Mandy Glass, Louis Flamand, Darren Wight, Benedikt Kaufer
Published in: Viruses, 10/8, 2018, Page(s) 401, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v10080401

The putative U94 integrase is dispensable for human herpesvirus 6 (HHV-6) chromosomal integration

Author(s): Nina Wallaschek, Annie Gravel, Louis Flamand, Benedikt B. Kaufer
Published in: Journal of General Virology, 97/8, 2016, Page(s) 1899-1903, ISSN 0022-1317
Publisher: Society for General Microbiology
DOI: 10.1099/jgv.0.000502

Telomeres and Telomerase: Role in Marek’s Disease Virus Pathogenesis, Integration and Tumorigenesis

Author(s): Ahmed Kheimar, Renato Previdelli, Darren Wight, Benedikt Kaufer
Published in: Viruses, 9/7, 2017, Page(s) 173, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v9070173

Identification of the Receptor and Cellular Ortholog of the Marek's Disease Virus (MDV) CXC Chemokine

Author(s): Sonja Haertle, Ibrahim Alzuheir, Florian Busalt, Victoria Waters, Pete Kaiser, Benedikt B. Kaufer
Published in: Frontiers in Microbiology, 8, 2017, ISSN 1664-302X
Publisher: Frontiers Media
DOI: 10.3389/fmicb.2017.02543

Viral Proteins U41 and U70 of Human Herpesvirus 6A Are Dispensable for Telomere Integration

Author(s): Darren Wight, Nina Wallaschek, Anirban Sanyal, Sandra Weller, Louis Flamand, Benedikt Kaufer
Published in: Viruses, 10/11, 2018, Page(s) 656, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v10110656

Role for the shelterin protein TRF2 in human herpesvirus 6A/B chromosomal integration

Author(s): Shella Gilbert-Girard, Annie Gravel, Vanessa Collin, Darren J. Wight, Benedikt B. Kaufer, Eros Lazzerini-Denchi, Louis Flamand
Published in: PLOS Pathogens, 16/4, 2020, Page(s) e1008496, ISSN 1553-7374
Publisher: PLoS
DOI: 10.1371/journal.ppat.1008496

Chromatin Profiles of Chromosomally Integrated Human Herpesvirus-6A

Author(s): Anthony J. Saviola, Cosima Zimmermann, Michael P. Mariani, Sylvia A. Signorelli, Diana L. Gerrard, Joseph R. Boyd, Darren J. Wight, Guillaume Morissette, Annie Gravel, Isabelle Dubuc, Louis Flamand, Benedikt B. Kaufer, Seth Frietze
Published in: Frontiers in Microbiology, 10, 2019, ISSN 1664-302X
Publisher: Frontiers Media
DOI: 10.3389/fmicb.2019.01408

Comparative Analysis of Roseoloviruses in Humans, Pigs, Mice, and Other Species

Author(s): Joachim Denner, Tarin M. Bigley, Tuan L. Phan, Cosima Zimmermann, Xiaofeng Zhou, Benedikt B. Kaufer
Published in: Viruses, 11/12, 2019, Page(s) 1108, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v11121108

The Telomeric Repeats of Human Herpesvirus 6A (HHV-6A) Are Required for Efficient Virus Integration

Author(s): Nina Wallaschek, Anirban Sanyal, Fabian Pirzer, Annie Gravel, Yasuko Mori, Louis Flamand, Benedikt B. Kaufer
Published in: PLOS Pathogens, 12/5, 2016, Page(s) e1005666, ISSN 1553-7374
Publisher: PLOS
DOI: 10.1371/journal.ppat.1005666

Higher-Order Chromatin Structures of Chromosomally Integrated HHV-6A Predict Integration Sites

Author(s): Michael Mariani, Cosima Zimmerman, Princess Rodriguez, Ellie Hasenohr, Diana L. Gerrard, Alyssa Richman, Andrea Dest, Louis Flamand, Benedikt Kaufer, Seth Frietze
Published in: Front. Cell. Infect. Microbiol., 2021, ISSN 2235-2988
Publisher: Frontiers Media S. A.
DOI: 10.3389/fcimb.2021.612656

The Promyelocytic Leukemia Protein facilitates human herpesvirus 6B chromosomal integration, immediate-early 1 protein multiSUMOylation and its localization at telomeres

Author(s): Vanessa Collin, Annie Gravel, Benedikt B. Kaufer, Louis Flamand
Published in: PLOS Pathogens, 16/7, 2020, Page(s) e1008683, ISSN 1553-7374
Publisher: PLoS Pathogens
DOI: 10.1371/journal.ppat.1008683