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Mechanisms of protein translocation in ER-associated protein degradation and the related protein import into the apicoplast of Plasmodium falciparum

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Hrd1 forms the retrotranslocation pore regulated by auto-ubiquitination and binding of misfolded proteins

Author(s): Vedran Vasic, Niels Denkert, Claudia C. Schmidt, Dietmar Riedel, Alexander Stein, Michael Meinecke
Published in: Nature Cell Biology, 2020, ISSN 1465-7392
DOI: 10.1038/s41556-020-0473-4

Quality Control of Protein Complex Assembly by a Transmembrane Recognition Factor

Author(s): Nivedita Natarajan, Ombretta Foresti, Kim Wendrich, Alexander Stein, Pedro Carvalho
Published in: Molecular Cell, Issue 77/1, 2020, Page(s) 108-119.e9, ISSN 1097-2765
DOI: 10.1016/j.molcel.2019.10.003

Doa10 is a membrane protein retrotranslocase in ER-associated protein degradation

Author(s): Claudia C Schmidt, Vedran Vasic, Alexander Stein
Published in: eLife, Issue 9, 2020, ISSN 2050-084X
DOI: 10.7554/elife.56945

Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3

Author(s): Stefan Schoebel, Wei Mi, Alexander Stein, Sergey Ovchinnikov, Ryan Pavlovicz, Frank DiMaio, David Baker, Melissa G. Chambers, Huayou Su, Dongsheng Li, Tom A. Rapoport, Maofu Liao
Published in: Nature, Issue 548/7667, 2017, Page(s) 352-355, ISSN 0028-0836
DOI: 10.1038/nature23314