Dynamic Penetrating Peptide Adaptamers

Project Information

DYNAP

Grant agreement ID: 677786

DOI

10.3030/677786

Project closed

EC signature date 16 December 2015

Start date 1 February 2016

End date 31 July 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 492 525,00

EU contribution

€ 1 492 525,00

Coordinated by

UNIVERSIDAD DE SANTIAGO DE COMPOSTELA
Spain

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (34)

Spatially Controlled Supramolecular Polymerization of Peptide Nanotubes by Microfluidics

Author(s): Alejandro Méndez-Ardoy, Alfonso Bayón-Fernández, Ziyi Yu, Chris Abell, Juan R. Granja, Javier Montenegro
Published in: Angewandte Chemie International Edition, Issue 59 (17), 2020, Page(s) 6902-6908, ISSN 1521-3773
Publisher: Wiley VCH Verlag GmBH
DOI: 10.1002/anie.202000103

Stronger Together: Multivalent Phage Capsids Inhibit Virus Entry

Author(s): Iván Gallego, Irene Lostalé-Seijo, Javier Montenegro
Published in: ChemBioChem, Issue 22, 2021, Page(s) 478-480, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202000536

A 3D Peptide/[60]Fullerene Hybrid for Multivalent Recognition

Author(s): Iván Gallego, Javier Ramos-Soriano, Alejandro Méndez-Ardoy, Justo Cabrera-González, Irene Lostalé-Seijo, Beatriz M. Illescas, Jose J. Reina, Nazario Martín, Javier Montenegro
Published in: Angewandte Chemie International Edition, Issue 61 (41), 2022, Page(s) e202210043, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202210043

Bottom-up supramolecular assembly in two dimensions

Author(s): Ignacio Insua; Julian Bergueiro; Alejandro Méndez-Ardoy; Irene Lostalé-Seijo; Javier Montenegro
Published in: Chemical Science, Issue 13, 2021, Page(s) 3057-3068, ISSN 2041-6539
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1sc05667k

Supramolecular caging for cytosolic delivery of anionic probes

Author(s): Héctor Fernández-Caro; Irene Lostalé-Seijo; Miguel Martínez-Calvo; Jesús Mosquera; José L. Mascareñas; Javier Montenegro
Published in: Chemical Science, Issue 10, 2019, Page(s) 8930-8938, ISSN 2041-6539
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9sc02906k

Boron clusters as broadband membrane carriers

Author(s): Andrea Barba-Bon, Giulia Salluce, Irene Lostalé-Seijo, Khaleel. I. Assaf, Andreas Hennig, Javier Montenegro, Werner M. Nau
Published in: Nature, Issue 603, 2022, Page(s) 637-642, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-04413-w

Synthesis and Supramolecular Functional Assemblies of Ratiometric pH Probes

Author(s): Alejandro Méndez-Ardoy, José J. Reina, Javier Montenegro
Published in: Chemistry - A European Journal, Issue 26 (34), 2020, Page(s) 7516-7536, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201904834

An Adhesive Peptide from the C-Terminal Domain of α-Synuclein for Single-Layer Adsorption of Nanoparticles onto Substrates

Author(s): Ghibom Bhak, Alejandro Méndez-Ardoy, Albert Escobedo, Xavier Salvatella, Javier Montenegro
Published in: Bioconjugate Chemistry, Issue 31 (12), 2020, Page(s) 2759-2766, ISSN 1043-1802
Publisher: American Chemical Society
DOI: 10.1021/acs.bioconjchem.0c00544

Péptidos penetrantes celulares: descripción, mecanismo y aplicaciones

Author(s): Alicia Rioboo, Iván Gallego, Javier Montenegro
Published in: Anales de Química de la RSEQ, Issue 115, 2019, Page(s) 9-21, ISSN 2792-5250
Publisher: Real Sociedad Española de Química

1D to 2D Self Assembly of Cyclic Peptides

Author(s): Ignacio Insua, Javier Montenegro
Published in: Journal of the American Chemical Society, Issue 00027863, 2020, Page(s) 300-307, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.9b10582

Supramolecular fibrillation of peptide amphiphiles induces environmental responses in aqueous droplets

Author(s): Richard Booth, Ignacio Insua, Sahnawaz Ahmed, Alicia Rioboo, Javier Montenegro
Published in: Nature Communications, Issue 20411723, 2021, Page(s) 6421, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-26681-2

Monitoring the Formation of Amyloid Oligomers Using Photoluminescence Anisotropy.

Author(s): Bo Jiang; Amir Aliyan; Nathan P. Cook; Andrea Augustine; Ghibom Bhak; Rodrigo R. Maldonado; Ashleigh D. Smith McWilliams; Erick I. Saavedra Flores; Nicolas Mendez; Mohammad Shahnawaz; Fernando Godoy; Javier Montenegro; Ines Moreno-Gonzalez; Ines Moreno-Gonzalez; Angel A. Martí
Published in: Journal of the American Chemical Society, Issue 141 (39), 2019, Page(s) 15605-15610, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.9b06966

Sequence Decoding of 1D to 2D Self‐Assembling Cyclic Peptides

Author(s): Sandra Díaz, Ignacio Insua, Ghibom Bhak, Javier Montenegro
Published in: Chemistry - A European journal, Issue 26 (64), 2020, Page(s) 14765-14770, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202003265

Short oligoalanine helical peptides for supramolecular nanopore assembly and protein cytosolic delivery

Author(s): Marta Pazo, Giulia Salluce, Irene Lostalé-Seijo, Marisa Juanes, Francisco Gonzalez, Rebeca Garcia-Fandiño, Javier Montenegro
Published in: RSC Chemical Biology, Issue 2, 2021, Page(s) 503-512, ISSN 2633-0679
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0cb00103a

Oligoalanine helical callipers for cell penetration

Author(s): Marta Pazo, Marisa Juanes, Irene Lostalé-Seijo, Javier Montenegro
Published in: Chemical Communications, Issue 54/50, 2018, Page(s) 6919-6922, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8cc02304b

Supramolecular Recognition and Selective Protein Uptake by Peptide Hybrids

Author(s): Marisa Juanes, Irene Lostalé-Seijo, Juan R. Granja, Javier Montenegro
Published in: Chemistry - A European Journal, Issue 24/42, 2018, Page(s) 10689-10698, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201800706

pH-Triggered self-assembly and hydrogelation of cyclic peptide nanotubes confined in water micro-droplets

Author(s): Alejandro Méndez-Ardoy, Juan R. Granja, Javier Montenegro
Published in: Nanoscale Horizons, Issue 3/4, 2018, Page(s) 391-396, ISSN 2055-6756
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8nh00009c

Novel Supramolecular Nanoparticles Derived from Cucurbit[7]uril and Zwitterionic Surfactants

Author(s): J. Fernández-Rosas, Marcia Pessêgo, Angel Acuña, Carlos Vázquez-Vázquez, Javier Montenegro, Mercedes Parajó, Pedro Rodríguez-Dafonte, Faruk Nome, Luis Garcia-Rio
Published in: Langmuir, Issue 34/11, 2018, Page(s) 3485-3493, ISSN 0743-7463
Publisher: American Chemical Society
DOI: 10.1021/acs.langmuir.7b04234

Glycosyl Aldehydes: New Scaffolds for the Synthesis of Neoglycoconjugates via Bioorthogonal Oxime Bond Formation

Author(s): Javier Montenegro, José Reina, Alicia Rioboo
Published in: Synthesis, Issue 50/04, 2018, Page(s) 831-845, ISSN 0039-7881
Publisher: Georg Thieme Verlag
DOI: 10.1055/s-0036-1591082

Peptide/Cas9 nanostructures for ribonucleoprotein cell membrane transport and gene edition

Author(s): Irene Lostalé-Seijo, Iria Louzao, Marisa Juanes, Javier Montenegro
Published in: Chemical Science, Issue 8/12, 2017, Page(s) 7923-7931, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/c7sc03918b

Highlights from the 52nd EUCHEM conference on stereochemistry, Bürgenstock, Switzerland, May 2017

Author(s): Javier Montenegro, Robert J. Phipps
Published in: Chemical Communications, Issue 53/72, 2017, Page(s) 9960-9966, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/c7cc90258a

Where in the cell is our cargo? Current methods to study intracellular cytosolic localization.

Author(s): Alejandro Méndez Ardoy, Irene Lostalé-Seijo, Javier Montenegro
Published in: ChemBioChem, 2018, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201800390

Different-Length Hydrazone Activated Polymers for Plasmid DNA Condensation and Cellular Transfection

Author(s): Juan M. Priegue, Irene Lostalé-Seijo, Daniel Crisan, Juan R. Granja, Francisco Fernández-Trillo, Javier Montenegro
Published in: Biomacromolecules, Issue 19/7, 2018, Page(s) 2638-2649, ISSN 1525-7797
Publisher: American Chemical Society
DOI: 10.1021/acs.biomac.8b00252

Self-assembled micro-fibres by oxime connection of linear peptide amphiphiles

Author(s): Richard Booth, Ignacio Insua, Ghibom Bhak, Javier Montenegro
Published in: Organic & Biomolecular Chemistry, Issue 17/7, 2019, Page(s) 1984-1991, ISSN 1477-0520
Publisher: Royal Society of Chemistry
DOI: 10.1039/C8OB02243G

Synthetic materials at the forefront of gene delivery

Author(s): Irene Lostalé-Seijo, Javier Montenegro
Published in: Nature Reviews Chemistry, Issue 2/10, 2018, Page(s) 258-277, ISSN 2397-3358
Publisher: Springer Nature
DOI: 10.1038/s41570-018-0039-1

Glycosylated Cell Penetrating Peptides, GCPPs

Author(s): Ivan Gallego, Alicia Rioboo, Jose J Reina, Bernardo Díaz, Ángeles Canales, F Javier Cañada, Jorge Guerra-Varela, Laura Sánchez, Javier Montenegro
Published in: ChemBioChem, Issue 20 (11), 2019, Page(s) 1400-1409, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201800720

Supramolecular functional assemblies: dynamic membrane transporters and peptide nanotubular composites

Author(s): Alberto Fuertes, Marisa Juanes, Juan R. Granja, Javier Montenegro
Published in: Chem. Commun., Issue 53/56, 2017, Page(s) 7861-7871, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/C7CC02997G

Hydrazone-modulated peptides for efficient gene transfection

Author(s): Iria Louzao, Rebeca García-Fandiño, Javier Montenegro
Published in: J. Mater. Chem. B, Issue 5/23, 2017, Page(s) 4426-4434, ISSN 2050-7518
Publisher: Royal Society of Chemistry
DOI: 10.1039/C7TB00179G

In Situ Functionalized Polymers for siRNA Delivery

Author(s): Juan M. Priegue, Daniel N. Crisan, José Martínez-Costas, Juan R. Granja, Francisco Fernandez-Trillo, Javier Montenegro
Published in: Angewandte Chemie International Edition, Issue 55/26, 2016, Page(s) 7492-7495, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201601441

Poly(acryloyl hydrazide), a versatile scaffold for the preparation of functional polymers: synthesis and post-polymerisation modification

Author(s): Daniel N. Crisan, Oliver Creese, Ranadeb Ball, Jose Luis Brioso, Ben Martyn, Javier Montenegro, Francisco Fernandez-Trillo
Published in: Polym. Chem., Issue 8/31, 2017, Page(s) 4576-4584, ISSN 1759-9954
Publisher: Royal Society of Chemistry
DOI: 10.1039/C7PY00535K

Tuning the Properties of Penetrating Peptides by Oxime Conjugation

Author(s): Javier Montenegro, Marta Pazo, Héctor Fernández-Caro, Juan Priegue, Irene Lostalé-Seijo
Published in: Synlett, Issue 28/08, 2017, Page(s) 924-928, ISSN 0936-5214
Publisher: Georg Thieme Verlag
DOI: 10.1055/s-0036-1588689

Messenger RNA delivery by hydrazone-activated polymers

Author(s): Marisa Juanes; Oliver Creese; Paco Fernandez-Trillo; Javier Montenegro
Published in: MedChemComm, Issue 20402511, 2019, Page(s) 1138-1144, ISSN 2040-2511
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9md00231f

The emergence of order: A closer look at peptide assembly and its complexity

Author(s): Alejandro Méndez-Ardoy, Julian Bergueiro, Javier Montenegro
Published in: Matter, Issue 4 (10), 2021, Page(s) P3081-3083, ISSN 2590-2393
Publisher: Elsevier
DOI: 10.1016/j.matt.2021.09.009

Synthetic Supramolecular Systems in Life-like Materials and Protocell Models

Author(s): Ignacio Insua, Javier Montenegro
Published in: Chem, Issue 24519294, 2020, Page(s) 1652-1682, ISSN 2451-9294
Publisher: Cell Press
DOI: 10.1016/j.chempr.2020.06.005

Book chapters (1)

Cyclization and self-assembly of cyclic peptides

Author(s): Alejandro Méndez-Ardoy, Ignacio Insua, Juan R. Granja, Javier Montenegro
Published in: Peptide Macrocycles. Methods in Molecular Biology., Issue 2371, 2022, Page(s) 449-466, ISBN 978-1-0716-1689-5
Publisher: Humana Press
DOI: 10.1007/978-1-0716-1689-5_24

Intellectual Property Rights

Patent (2)

USE OF A BORON CLUSTER AS TRANSMEMBRANE CARRIER

Application/Publication number: 20 21065748
Date: 2021-06-11
Applicant(s): UNIVERSIDAD DE SANTIAGO DE COMPOSTELA

AQUEOUS SYNTHESIS AND IN-SITU RAPID SCREENING OF AMPHIPHILIC POLYMERS

Application/Publication number: EP 16822404
Date: 2016-12-14
Applicant(s): UNIVERSIDAD DE SANTIAGO DE COMPOSTELA

Other (2)

Cell penetrating peptides

Application/Publication number: EP183822168 EP183822168
Date: 2018-04-18
Applicant(s): UNIVERSIDAD DE SANTIAGO DE COMPOSTELA

Cationic Peptides for intracellular delivery

Application/Publication number: """EP" "22382596"""
Date: 2022-06-23
Applicant(s): UNIVERSIDAD DE SANTIAGO DE COMPOSTELA