Dynamic Penetrating Peptide Adaptamers

Project Information

DYNAP

Grant agreement ID: 677786

DOI 10.3030/677786

Project closed

EC signature date 16 December 2015

Start date 1 February 2016

End date 31 July 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 492 525,00

EU contribution € 1 492 525,00

Coordinated by

UNIVERSIDAD DE SANTIAGO DE COMPOSTELA
Spain

Publications

Peer reviewed articles (34)

Spatially Controlled Supramolecular Polymerization of Peptide Nanotubes by Microfluidics

Author(s): Alejandro Méndez-Ardoy, Alfonso Bayón-Fernández, Ziyi Yu, Chris Abell, Juan R. Granja, Javier Montenegro
Published in: Angewandte Chemie International Edition, Issue 15213773, 2020, Page(s) 6902-6908, ISSN 1521-3773
Publisher: Wiley VCH Verlag GmBH
DOI: 10.1002/anie.202000103

Stronger Together: Multivalent Phage Capsids Inhibit Virus Entry

Author(s): Iván Gallego, Irene Lostalé-Seijo, Javier Montenegro
Published in: ChemBioChem, Issue 14394227, 2021, Page(s) 478-480, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202000536

A 3D Peptide/[60]Fullerene Hybrid for Multivalent Recognition

Author(s): Iván Gallego, Javier Ramos-Soriano, Alejandro Méndez-Ardoy, Justo Cabrera-González, Irene Lostalé-Seijo, Beatriz M. Illescas, Jose J. Reina, Nazario Martín, Javier Montenegro
Published in: Angewandte Chemie International Edition, Issue 14337851, 2022, Page(s) e202210043, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202210043

Bottom-up supramolecular assembly in two dimensions

Author(s): Ignacio Insua; Julian Bergueiro; Alejandro Méndez-Ardoy; Irene Lostalé-Seijo; Javier Montenegro
Published in: Chemical Science, Issue 20416539, 2021, Page(s) 3057-3068, ISSN 2041-6539
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1sc05667k

Supramolecular caging for cytosolic delivery of anionic probes

Author(s): Héctor Fernández-Caro; Irene Lostalé-Seijo; Miguel Martínez-Calvo; Jesús Mosquera; José L. Mascareñas; Javier Montenegro
Published in: Chemical Science, Issue 20416539, 2019, Page(s) 8930-8938, ISSN 2041-6539
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9sc02906k

Boron clusters as broadband membrane carriers

Author(s): Andrea Barba-Bon, Giulia Salluce, Irene Lostalé-Seijo, Khaleel. I. Assaf, Andreas Hennig, Javier Montenegro, Werner M. Nau
Published in: Nature, Issue 00280836, 2022, Page(s) 637-642, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-04413-w

Synthesis and Supramolecular Functional Assemblies of Ratiometric pH Probes

Author(s): Alejandro Méndez-Ardoy, José J. Reina, Javier Montenegro
Published in: Chemistry - A European Journal, Issue 09476539, 2020, Page(s) 7516-7536, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201904834

An Adhesive Peptide from the C-Terminal Domain of α-Synuclein for Single-Layer Adsorption of Nanoparticles onto Substrates

Author(s): Ghibom Bhak, Alejandro Méndez-Ardoy, Albert Escobedo, Xavier Salvatella, Javier Montenegro
Published in: Bioconjugate Chemistry, Issue 10431802, 2020, Page(s) 2759-2766, ISSN 1043-1802
Publisher: American Chemical Society
DOI: 10.1021/acs.bioconjchem.0c00544

Péptidos penetrantes celulares: descripción, mecanismo y aplicaciones

Author(s): Alicia Rioboo, Iván Gallego, Javier Montenegro
Published in: Anales de Química de la RSEQ, Issue 115, 2019, Page(s) 9-21, ISSN 2792-5250
Publisher: Real Sociedad Española de Química

1D to 2D Self Assembly of Cyclic Peptides

Author(s): Ignacio Insua, Javier Montenegro
Published in: Journal of the American Chemical Society, Issue 00027863, 2020, Page(s) 300-307, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.9b10582

Supramolecular fibrillation of peptide amphiphiles induces environmental responses in aqueous droplets

Author(s): Richard Booth, Ignacio Insua, Sahnawaz Ahmed, Alicia Rioboo, Javier Montenegro
Published in: Nature Communications, Issue 20411723, 2021, Page(s) 6421, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-26681-2

Monitoring the Formation of Amyloid Oligomers Using Photoluminescence Anisotropy.

Author(s): Bo Jiang; Amir Aliyan; Nathan P. Cook; Andrea Augustine; Ghibom Bhak; Rodrigo R. Maldonado; Ashleigh D. Smith McWilliams; Erick I. Saavedra Flores; Nicolas Mendez; Mohammad Shahnawaz; Fernando Godoy; Javier Montenegro; Ines Moreno-Gonzalez; Ines Moreno-Gonzalez; Angel A. Martí
Published in: Journal of the American Chemical Society, Issue 00027863, 2019, Page(s) 15605-15610, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.9b06966

Sequence Decoding of 1D to 2D Self‐Assembling Cyclic Peptides

Author(s): Sandra Díaz, Ignacio Insua, Ghibom Bhak, Javier Montenegro
Published in: Chemistry - A European journal, Issue 09476539, 2020, Page(s) 14765-14770, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202003265

Short oligoalanine helical peptides for supramolecular nanopore assembly and protein cytosolic delivery

Author(s): Marta Pazo, Giulia Salluce, Irene Lostalé-Seijo, Marisa Juanes, Francisco Gonzalez, Rebeca Garcia-Fandiño, Javier Montenegro
Published in: RSC Chemical Biology, Issue 26330679, 2021, Page(s) 503-512, ISSN 2633-0679
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0cb00103a

Oligoalanine helical callipers for cell penetration

Author(s): Marta Pazo, Marisa Juanes, Irene Lostalé-Seijo, Javier Montenegro
Published in: Chemical Communications, Issue 54/50, 2018, Page(s) 6919-6922, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8cc02304b

Supramolecular Recognition and Selective Protein Uptake by Peptide Hybrids

Author(s): Marisa Juanes, Irene Lostalé-Seijo, Juan R. Granja, Javier Montenegro
Published in: Chemistry - A European Journal, Issue 24/42, 2018, Page(s) 10689-10698, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201800706

pH-Triggered self-assembly and hydrogelation of cyclic peptide nanotubes confined in water micro-droplets

Author(s): Alejandro Méndez-Ardoy, Juan R. Granja, Javier Montenegro
Published in: Nanoscale Horizons, Issue 3/4, 2018, Page(s) 391-396, ISSN 2055-6756
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8nh00009c

Novel Supramolecular Nanoparticles Derived from Cucurbit[7]uril and Zwitterionic Surfactants

Author(s): J. Fernández-Rosas, Marcia Pessêgo, Angel Acuña, Carlos Vázquez-Vázquez, Javier Montenegro, Mercedes Parajó, Pedro Rodríguez-Dafonte, Faruk Nome, Luis Garcia-Rio
Published in: Langmuir, Issue 34/11, 2018, Page(s) 3485-3493, ISSN 0743-7463
Publisher: American Chemical Society
DOI: 10.1021/acs.langmuir.7b04234

Glycosyl Aldehydes: New Scaffolds for the Synthesis of Neoglycoconjugates via Bioorthogonal Oxime Bond Formation

Author(s): Javier Montenegro, José Reina, Alicia Rioboo
Published in: Synthesis, Issue 50/04, 2018, Page(s) 831-845, ISSN 0039-7881
Publisher: Georg Thieme Verlag
DOI: 10.1055/s-0036-1591082

Peptide/Cas9 nanostructures for ribonucleoprotein cell membrane transport and gene edition

Author(s): Irene Lostalé-Seijo, Iria Louzao, Marisa Juanes, Javier Montenegro
Published in: Chemical Science, Issue 8/12, 2017, Page(s) 7923-7931, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/c7sc03918b

Highlights from the 52nd EUCHEM conference on stereochemistry, Bürgenstock, Switzerland, May 2017

Author(s): Javier Montenegro, Robert J. Phipps
Published in: Chemical Communications, Issue 53/72, 2017, Page(s) 9960-9966, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/c7cc90258a

Where in the cell is our cargo? Current methods to study intracellular cytosolic localization.

Author(s): Alejandro Méndez Ardoy, Irene Lostalé-Seijo, Javier Montenegro
Published in: ChemBioChem, 2018, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201800390

Different-Length Hydrazone Activated Polymers for Plasmid DNA Condensation and Cellular Transfection

Author(s): Juan M. Priegue, Irene Lostalé-Seijo, Daniel Crisan, Juan R. Granja, Francisco Fernández-Trillo, Javier Montenegro
Published in: Biomacromolecules, Issue 19/7, 2018, Page(s) 2638-2649, ISSN 1525-7797
Publisher: American Chemical Society
DOI: 10.1021/acs.biomac.8b00252

Self-assembled micro-fibres by oxime connection of linear peptide amphiphiles

Author(s): Richard Booth, Ignacio Insua, Ghibom Bhak, Javier Montenegro
Published in: Organic & Biomolecular Chemistry, Issue 17/7, 2019, Page(s) 1984-1991, ISSN 1477-0520
Publisher: Royal Society of Chemistry
DOI: 10.1039/C8OB02243G

Synthetic materials at the forefront of gene delivery

Author(s): Irene Lostalé-Seijo, Javier Montenegro
Published in: Nature Reviews Chemistry, Issue 2/10, 2018, Page(s) 258-277, ISSN 2397-3358
Publisher: Springer Nature
DOI: 10.1038/s41570-018-0039-1

Glycosylated Cell Penetrating Peptides, GCPPs

Author(s): Ivan Gallego, Alicia Rioboo, Jose J Reina, Bernardo Díaz, Ángeles Canales, F Javier Cañada, Jorge Guerra-Varela, Laura Sánchez, Javier Montenegro
Published in: ChemBioChem, 2019, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201800720

Supramolecular functional assemblies: dynamic membrane transporters and peptide nanotubular composites

Author(s): Alberto Fuertes, Marisa Juanes, Juan R. Granja, Javier Montenegro
Published in: Chem. Commun., Issue 53/56, 2017, Page(s) 7861-7871, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/C7CC02997G

Hydrazone-modulated peptides for efficient gene transfection

Author(s): Iria Louzao, Rebeca García-Fandiño, Javier Montenegro
Published in: J. Mater. Chem. B, Issue 5/23, 2017, Page(s) 4426-4434, ISSN 2050-7518
Publisher: Royal Society of Chemistry
DOI: 10.1039/C7TB00179G

In Situ Functionalized Polymers for siRNA Delivery

Author(s): Juan M. Priegue, Daniel N. Crisan, José Martínez-Costas, Juan R. Granja, Francisco Fernandez-Trillo, Javier Montenegro
Published in: Angewandte Chemie International Edition, Issue 55/26, 2016, Page(s) 7492-7495, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201601441

Poly(acryloyl hydrazide), a versatile scaffold for the preparation of functional polymers: synthesis and post-polymerisation modification

Author(s): Daniel N. Crisan, Oliver Creese, Ranadeb Ball, Jose Luis Brioso, Ben Martyn, Javier Montenegro, Francisco Fernandez-Trillo
Published in: Polym. Chem., Issue 8/31, 2017, Page(s) 4576-4584, ISSN 1759-9954
Publisher: Royal Society of Chemistry
DOI: 10.1039/C7PY00535K

Tuning the Properties of Penetrating Peptides by Oxime Conjugation

Author(s): Javier Montenegro, Marta Pazo, Héctor Fernández-Caro, Juan Priegue, Irene Lostalé-Seijo
Published in: Synlett, Issue 28/08, 2017, Page(s) 924-928, ISSN 0936-5214
Publisher: Georg Thieme Verlag
DOI: 10.1055/s-0036-1588689

Messenger RNA delivery by hydrazone-activated polymers

Author(s): Marisa Juanes; Oliver Creese; Paco Fernandez-Trillo; Javier Montenegro
Published in: MedChemComm, Issue 20402511, 2019, Page(s) 1138-1144, ISSN 2040-2511
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9md00231f

The emergence of order: A closer look at peptide assembly and its complexity

Author(s): Alejandro Méndez-Ardoy, Julian Bergueiro, Javier Montenegro
Published in: Matter, Issue 25902393, 2021, Page(s) P3081-3083, ISSN 2590-2393
Publisher: Elsevier
DOI: 10.1016/j.matt.2021.09.009

Synthetic Supramolecular Systems in Life-like Materials and Protocell Models

Author(s): Ignacio Insua, Javier Montenegro
Published in: Chem, Issue 24519294, 2020, Page(s) 1652-1682, ISSN 2451-9294
Publisher: Cell Press
DOI: 10.1016/j.chempr.2020.06.005

Book chapters (1)

Cyclization and self-assembly of cyclic peptides

Author(s): Alejandro Méndez-Ardoy, Ignacio Insua, Juan R. Granja, Javier Montenegro
Published in: Peptide Macrocycles. Methods in Molecular Biology., Issue 2371, 2022, Page(s) 449-466, ISBN 978-1-0716-1689-5
Publisher: Humana Press
DOI: 10.1007/978-1-0716-1689-5_24

Intellectual Property Rights

Other (4)

Cell penetrating peptides

Application/Publication number: EP183822168 EP183822168
Date: 2018-04-18

Cationic Peptides for intracellular delivery

Application/Publication number: """EP" "22382596"""
Date: 2022-06-23
Applicant(s): UNIVERSIDAD DE SANTIAGO DE COMPOSTELA

Cell penetrating peptides

Application/Publication number: EP183822168 EP183822168
Date: 2018-04-18
Applicant(s): UNIVERSIDAD DE SANTIAGO DE COMPOSTELA

Cell penetrating peptides

Application/Publication number: EP183822168 EP183822168
Date: 2018-04-18

Patent (4)

AQUEOUS SYNTHESIS AND IN-SITU RAPID SCREENING OF AMPHIPHILIC POLYMERS

Application/Publication number: EP 16822404
Date: 2016-12-14

AQUEOUS SYNTHESIS AND IN-SITU RAPID SCREENING OF AMPHIPHILIC POLYMERS

Application/Publication number: EP 16822404
Date: 2016-12-14

USE OF A BORON CLUSTER AS TRANSMEMBRANE CARRIER

Application/Publication number: 20 21065748
Date: 2021-06-11
Applicant(s): UNIVERSIDAD DE SANTIAGO DE COMPOSTELA

AQUEOUS SYNTHESIS AND IN-SITU RAPID SCREENING OF AMPHIPHILIC POLYMERS

Application/Publication number: EP 16822404
Date: 2016-12-14
Applicant(s): UNIVERSIDAD DE SANTIAGO DE COMPOSTELA