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Signaling Cascades in Metabolic Diseases


Diacylglycerol-evoked activation of PKC and PKD isoforms in regulation of glucose and lipid metabolism: a review

Author(s): Katarzyna Kolczynska, Angel Loza-Valdes, Izabela Hawro, Grzegorz Sumara
Published in: Lipids in Health and Disease, Issue 19/1, 2020, ISSN 1476-511X
Publisher: BioMed Central
DOI: 10.1186/s12944-020-01286-8

The kinase PKD3 provides negative feedback on cholesterol and triglyceride synthesis by suppressing insulin signaling

Author(s): Alexander E Mayer, Mona C Löffler, Angel E Loza Valdés, Werner Schmitz, Rabih El-Merahbi, Jonathan Trujillo Viera, Manuela Erk, Thianzhou Zhang, Ursula Braun, Mathias Heikenwalder, Michael Leitges, Almut Schulze, Grzegorz Sumara
Published in: Science Signaling, 2019, ISSN 1945-0877
Publisher: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/scisignal.aav9150

A phosphoproteomic approach reveals that PKD3 controls PKA-mediated glucose and tyrosine metabolism

Author(s): Angel Loza-Valdes, Alexander E Mayer, Toufic Kassouf, Jonathan Trujillo-Viera, Werner Schmitz, Filip Dziaczkowski, Michael Leitges, Andreas Schlosser, Grzegorz Sumara
Published in: Life Science Alliance, Issue 4/8, 2021, Page(s) e202000863, ISSN 2575-1077
Publisher: Life Science Alliance, LLC
DOI: 10.26508/lsa.202000863

Impact of Conventional and Atypical MAPKs on the Development of Metabolic Diseases

Author(s): Toufic Kassouf, Grzegorz Sumara
Published in: Biomolecules, Issue 10/9, 2020, Page(s) 1256, ISSN 2218-273X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/biom10091256

Ndrg1 promotes adipocyte differentiation and sustains their function

Author(s): Kai Cai, Rabih El-Merahbi, Mona Loeffler, Alexander E. Mayer, Grzegorz Sumara
Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-017-07497-x

Protein kinase D1 deletion in adipocytes enhances energy dissipation and protects against adiposity

Author(s): Mona C Löffler, Alexander E Mayer, Jonathan Trujillo Viera, Angel Loza Valdes, Rabih El‐Merahbi, Carsten P Ade, Till Karwen, Werner Schmitz, Anja Slotta, Manuela Erk, Sudha Janaki‐Raman, Nuria Matesanz, Jorge L Torres, Miguel Marcos, Guadalupe Sabio, Martin Eilers, Almut Schulze, Grzegorz Sumara
Published in: The EMBO Journal, Issue 37/22, 2018, Page(s) e99182, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.201899182

The adrenergic-induced ERK3 pathway drives lipolysis and suppresses energy dissipation

Author(s): Rabih El-Merahbi, Jonathan Trujillo Viera, Angel Loza Valdes, Katarzyna Kolczynska, Saskia Reuter, Mona C. Löffler, Manuela Erk, Carsten P. Ade, Till Karwen, Alexander E. Mayer, Martin Eilers, Grzegorz Sumara
Published in: Genes & Development, Issue 34/7-8, 2020, Page(s) 495-510, ISSN 0890-9369
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.333617.119

Protein Kinase D2 drives chylomicron‐mediated lipid transport in the intestine and promotes obesity

Author(s): Jonathan Trujillo‐Viera, Rabih El‐Merahbi, Vanessa Schmidt, Till Karwen, Angel Loza‐Valdes, Akim Strohmeyer, Saskia Reuter, Minhee Noh, Magdalena Wit, Izabela Hawro, Sabine Mocek, Christina Fey, Alexander E Mayer, Mona C Löffler, Ilka Wilhelmi, Marco Metzger, Eri Ishikawa, Sho Yamasaki, Monika Rau, Andreas Geier, Mohammed Hankir, Florian Seyfried, Martin Klingenspor, Grzegorz Sumara
Published in: EMBO Molecular Medicine, Issue 13/5, 2021, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202013548

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