Signaling Cascades in Metabolic Diseases

Project Information

SiCMetabol

Grant agreement ID: 678119

DOI 10.3030/678119

Project closed

EC signature date 11 April 2016

Start date 1 June 2016

End date 30 November 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 499 128,00

EU contribution € 1 499 128,00

Coordinated by

INSTYTUT BIOLOGII DOSWIADCZALNEJ IM. M. NENCKIEGO POLSKIEJ AKADEMII NAUK
Poland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (8)

Diacylglycerol-evoked activation of PKC and PKD isoforms in regulation of glucose and lipid metabolism: a review

Author(s): Katarzyna Kolczynska, Angel Loza-Valdes, Izabela Hawro, Grzegorz Sumara
Published in: Lipids in Health and Disease, Issue 19/1, 2020, ISSN 1476-511X
Publisher: BioMed Central
DOI: 10.1186/s12944-020-01286-8

The kinase PKD3 provides negative feedback on cholesterol and triglyceride synthesis by suppressing insulin signaling

Author(s): Alexander E Mayer, Mona C Löffler, Angel E Loza Valdés, Werner Schmitz, Rabih El-Merahbi, Jonathan Trujillo Viera, Manuela Erk, Thianzhou Zhang, Ursula Braun, Mathias Heikenwalder, Michael Leitges, Almut Schulze, Grzegorz Sumara
Published in: Science Signaling, 2019, ISSN 1945-0877
Publisher: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/scisignal.aav9150

A phosphoproteomic approach reveals that PKD3 controls PKA-mediated glucose and tyrosine metabolism

Author(s): Angel Loza-Valdes, Alexander E Mayer, Toufic Kassouf, Jonathan Trujillo-Viera, Werner Schmitz, Filip Dziaczkowski, Michael Leitges, Andreas Schlosser, Grzegorz Sumara
Published in: Life Science Alliance, Issue 4/8, 2021, Page(s) e202000863, ISSN 2575-1077
Publisher: Life Science Alliance, LLC
DOI: 10.26508/lsa.202000863

Impact of Conventional and Atypical MAPKs on the Development of Metabolic Diseases

Author(s): Toufic Kassouf, Grzegorz Sumara
Published in: Biomolecules, Issue 10/9, 2020, Page(s) 1256, ISSN 2218-273X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/biom10091256

Ndrg1 promotes adipocyte differentiation and sustains their function

Author(s): Kai Cai, Rabih El-Merahbi, Mona Loeffler, Alexander E. Mayer, Grzegorz Sumara
Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-017-07497-x

Protein kinase D1 deletion in adipocytes enhances energy dissipation and protects against adiposity

Author(s): Mona C Löffler, Alexander E Mayer, Jonathan Trujillo Viera, Angel Loza Valdes, Rabih El‐Merahbi, Carsten P Ade, Till Karwen, Werner Schmitz, Anja Slotta, Manuela Erk, Sudha Janaki‐Raman, Nuria Matesanz, Jorge L Torres, Miguel Marcos, Guadalupe Sabio, Martin Eilers, Almut Schulze, Grzegorz Sumara
Published in: The EMBO Journal, Issue 37/22, 2018, Page(s) e99182, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.201899182

The adrenergic-induced ERK3 pathway drives lipolysis and suppresses energy dissipation

Author(s): Rabih El-Merahbi, Jonathan Trujillo Viera, Angel Loza Valdes, Katarzyna Kolczynska, Saskia Reuter, Mona C. Löffler, Manuela Erk, Carsten P. Ade, Till Karwen, Alexander E. Mayer, Martin Eilers, Grzegorz Sumara
Published in: Genes & Development, Issue 34/7-8, 2020, Page(s) 495-510, ISSN 0890-9369
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.333617.119

Protein Kinase D2 drives chylomicron‐mediated lipid transport in the intestine and promotes obesity

Author(s): Jonathan Trujillo‐Viera, Rabih El‐Merahbi, Vanessa Schmidt, Till Karwen, Angel Loza‐Valdes, Akim Strohmeyer, Saskia Reuter, Minhee Noh, Magdalena Wit, Izabela Hawro, Sabine Mocek, Christina Fey, Alexander E Mayer, Mona C Löffler, Ilka Wilhelmi, Marco Metzger, Eri Ishikawa, Sho Yamasaki, Monika Rau, Andreas Geier, Mohammed Hankir, Florian Seyfried, Martin Klingenspor, Grzegorz Sumara
Published in: EMBO Molecular Medicine, Issue 13/5, 2021, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202013548