CORDIS - EU research results

Cofactor Binding Antibodies – Basic Aspects and Therapeutic Innovations


Assessment of the breadth of binding promiscuity of heme towards human proteins

Author(s): Lubka T. Roumenina, Jordan D. Dimitrov
Published in: Biological Chemistry, Issue 403, 2022, Page(s) 1083–1090, ISSN 1431-6730
Publisher: Walter de Gruyter GmbH & Co. KG
DOI: 10.1515/hsz-2022-0226

Evolutionary trajectory of receptor binding specificity and promiscuity of the spike protein of SARS-CoV-2

Author(s): Cyril Planchais, Alejandra Reyes-Ruiz, Robin Lacombe, Alessandra Zarantonello, Maxime Lecerf, Margot Revel, Lubka T. Roumenina, Boris P. Atanasov, Hugo Mouquet, Jordan D. Dimitrov
Published in: Protein Science, Issue 31, 2022, Page(s) e4447, ISSN 1469-896X
Publisher: John Wiley & Sons, Inc.
DOI: 10.1002/pro.4447

Aromatic Guanylhydrazones for the Control of Heme-Induced Antibody Polyreactivity

Author(s): Nina Božinović, Vladimir Ajdačić, Jelena Lazic, Maxime Lecerf, Victoria Daventure, Jasmina Nikodinovic-Runic, Igor M. Opsenica, Jordan D. Dimitrov
Published in: ACS Omega, Issue 4/24, 2019, Page(s) 20450-20458, ISSN 2470-1343
Publisher: American Chemical Society
DOI: 10.1021/acsomega.9b01548

Oxidized hemoglobin triggers polyreactivity and autoreactivity of human IgG via transfer of heme

Author(s): Cyril Planchais, Remi Noe, Marie Gilbert, Maxime Lecerf, Srini V. Kaveri, Sébastien Lacroix-Desmazes, Lubka T. Roumenina & Jordan D. Dimitrov
Published in: Communications Biology, Issue 6/168, 2023, ISSN 2399-3642
Publisher: Nature Publishing Group
DOI: 10.1038/s42003-023-04535-5

Interaction of clinical-stage antibodies with heme predicts their physiochemical and binding qualities

Author(s): Maxime Lecerf, Alexia Kanyavuz, Sofia Rossini, Jordan D. Dimitrov
Published in: Communications Biology, Issue 4/1, 2021, ISSN 2399-3642
Publisher: Springer Nature
DOI: 10.1038/s42003-021-01931-7

HIV-1 Envelope Recognition by Polyreactive and Cross-Reactive Intestinal B Cells

Author(s): Cyril Planchais, Ayrin Kök, Alexia Kanyavuz, Valérie Lorin, Timothée Bruel, Florence Guivel-Benhassine, Tim Rollenske, Julie Prigent, Thierry Hieu, Thierry Prazuck, Laurent Lefrou, Hedda Wardemann, Olivier Schwartz, Jordan D. Dimitrov, Laurent Hocqueloux, Hugo Mouquet
Published in: Cell Reports, Issue 27/2, 2019, Page(s) 572-585.e7, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.03.032

P-selectin drives complement attack on endothelium during intravascular hemolysis in TLR-4/heme-dependent manner

Author(s): Nicolas S. Merle, Romain Paule, Juliette Leon, Marie Daugan, Tania Robe-Rybkine, Victoria Poillerat, Carine Torset, Véronique Frémeaux-Bacchi, Jordan D. Dimitrov, Lubka T. Roumenina
Published in: Proceedings of the National Academy of Sciences, Issue 116/13, 2019, Page(s) 6280-6285, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1814797116

Anti-inflammatory activity of intravenous immunoglobulin through scavenging of heme

Author(s): Marie Wiatr, Nicolas S. Merle, Idris Boudhabhay, Victoria Poillerat, Sofia Rossini, Maxime Lecerf, Srini V. Kaveri, Sébastian Lacroix-Desmazes, Lubka T. Roumenina, Jordan D. Dimitrov
Published in: Molecular Immunology, Issue 111, 2019, Page(s) 205-208, ISSN 0161-5890
Publisher: Pergamon Press
DOI: 10.1016/j.molimm.2019.04.020

Breaking the law: unconventional strategies for antibody diversification

Author(s): Alexia Kanyavuz, Annaelle Marey-Jarossay, Sébastien Lacroix-Desmazes, Jordan D. Dimitrov
Published in: Nature Reviews Immunology, 2019, ISSN 1474-1733
Publisher: Nature Publishing Group
DOI: 10.1038/s41577-019-0126-7

Use of cysteine as a spectroscopic probe for determination of heme-scavenging capacity of serum proteins and whole human serum

Author(s): Rémi Noé, Nina Bozinovic, Maxime Lecerf, Sébastien Lacroix-Desmazes, Jordan D. Dimitrov
Published in: Journal of Pharmaceutical and Biomedical Analysis, Issue 172, 2019, Page(s) 311-319, ISSN 0731-7085
Publisher: Elsevier BV
DOI: 10.1016/j.jpba.2019.05.013

Hyperoxidized Species of Heme Have a Potent Capacity to Induce Autoreactivity of Human IgG Antibodies

Author(s): Marie Wiatr, Maya Hadzhieva, Maxime Lecerf, Rémi Noé, Sune Justesen, Sébastien Lacroix-Desmazes , Marie-Agnès Dragon-Durey, Jordan D Dimitrov
Published in: International Journal of Molecular Sciences, Issue 24, 2023, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24043416

Functional Changes of Therapeutic Antibodies upon Exposure to Pro-Oxidative Agents

Author(s): Maxime Lecerf, Robin Lacombe, Alexia Kanyavuz, Jordan D Dimitrov
Published in: Antibodies (Basel), Issue 11, 2022, ISSN 2073-4468
Publisher: MDPI
DOI: 10.3390/antib11010011

Intellectual Property Rights


Application/Publication number: 19 762816
Date: 2019-09-09

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