Cofactor Binding Antibodies – Basic Aspects and Therapeutic Innovations

Project Information

CoBABATI

Grant agreement ID: 678905

DOI 10.3030/678905

Project closed

EC signature date 12 July 2016

Start date 1 September 2016

End date 28 February 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 255 000,00

EU contribution € 1 255 000,00

Coordinated by

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

Publications

Peer reviewed articles (12)

Assessment of the breadth of binding promiscuity of heme towards human proteins

Author(s): Lubka T. Roumenina, Jordan D. Dimitrov
Published in: Biological Chemistry, Issue 403, 2022, Page(s) 1083–1090, ISSN 1431-6730
Publisher: Walter de Gruyter GmbH & Co. KG
DOI: 10.1515/hsz-2022-0226

Evolutionary trajectory of receptor binding specificity and promiscuity of the spike protein of SARS-CoV-2

Author(s): Cyril Planchais, Alejandra Reyes-Ruiz, Robin Lacombe, Alessandra Zarantonello, Maxime Lecerf, Margot Revel, Lubka T. Roumenina, Boris P. Atanasov, Hugo Mouquet, Jordan D. Dimitrov
Published in: Protein Science, Issue 31, 2022, Page(s) e4447, ISSN 1469-896X
Publisher: John Wiley & Sons, Inc.
DOI: 10.1002/pro.4447

Aromatic Guanylhydrazones for the Control of Heme-Induced Antibody Polyreactivity

Author(s): Nina Božinović, Vladimir Ajdačić, Jelena Lazic, Maxime Lecerf, Victoria Daventure, Jasmina Nikodinovic-Runic, Igor M. Opsenica, Jordan D. Dimitrov
Published in: ACS Omega, Issue 4/24, 2019, Page(s) 20450-20458, ISSN 2470-1343
Publisher: American Chemical Society
DOI: 10.1021/acsomega.9b01548

Oxidized hemoglobin triggers polyreactivity and autoreactivity of human IgG via transfer of heme

Author(s): Cyril Planchais, Remi Noe, Marie Gilbert, Maxime Lecerf, Srini V. Kaveri, Sébastien Lacroix-Desmazes, Lubka T. Roumenina & Jordan D. Dimitrov
Published in: Communications Biology, Issue 6/168, 2023, ISSN 2399-3642
Publisher: Nature Publishing Group
DOI: 10.1038/s42003-023-04535-5

Interaction of clinical-stage antibodies with heme predicts their physiochemical and binding qualities

Author(s): Maxime Lecerf, Alexia Kanyavuz, Sofia Rossini, Jordan D. Dimitrov
Published in: Communications Biology, Issue 4/1, 2021, ISSN 2399-3642
Publisher: Springer Nature
DOI: 10.1038/s42003-021-01931-7

HIV-1 Envelope Recognition by Polyreactive and Cross-Reactive Intestinal B Cells

Author(s): Cyril Planchais, Ayrin Kök, Alexia Kanyavuz, Valérie Lorin, Timothée Bruel, Florence Guivel-Benhassine, Tim Rollenske, Julie Prigent, Thierry Hieu, Thierry Prazuck, Laurent Lefrou, Hedda Wardemann, Olivier Schwartz, Jordan D. Dimitrov, Laurent Hocqueloux, Hugo Mouquet
Published in: Cell Reports, Issue 27/2, 2019, Page(s) 572-585.e7, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.03.032

P-selectin drives complement attack on endothelium during intravascular hemolysis in TLR-4/heme-dependent manner

Author(s): Nicolas S. Merle, Romain Paule, Juliette Leon, Marie Daugan, Tania Robe-Rybkine, Victoria Poillerat, Carine Torset, Véronique Frémeaux-Bacchi, Jordan D. Dimitrov, Lubka T. Roumenina
Published in: Proceedings of the National Academy of Sciences, Issue 116/13, 2019, Page(s) 6280-6285, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1814797116

Anti-inflammatory activity of intravenous immunoglobulin through scavenging of heme

Author(s): Marie Wiatr, Nicolas S. Merle, Idris Boudhabhay, Victoria Poillerat, Sofia Rossini, Maxime Lecerf, Srini V. Kaveri, Sébastian Lacroix-Desmazes, Lubka T. Roumenina, Jordan D. Dimitrov
Published in: Molecular Immunology, Issue 111, 2019, Page(s) 205-208, ISSN 0161-5890
Publisher: Pergamon Press
DOI: 10.1016/j.molimm.2019.04.020

Breaking the law: unconventional strategies for antibody diversification

Author(s): Alexia Kanyavuz, Annaelle Marey-Jarossay, Sébastien Lacroix-Desmazes, Jordan D. Dimitrov
Published in: Nature Reviews Immunology, 2019, ISSN 1474-1733
Publisher: Nature Publishing Group
DOI: 10.1038/s41577-019-0126-7

Use of cysteine as a spectroscopic probe for determination of heme-scavenging capacity of serum proteins and whole human serum

Author(s): Rémi Noé, Nina Bozinovic, Maxime Lecerf, Sébastien Lacroix-Desmazes, Jordan D. Dimitrov
Published in: Journal of Pharmaceutical and Biomedical Analysis, Issue 172, 2019, Page(s) 311-319, ISSN 0731-7085
Publisher: Elsevier BV
DOI: 10.1016/j.jpba.2019.05.013

Hyperoxidized Species of Heme Have a Potent Capacity to Induce Autoreactivity of Human IgG Antibodies

Author(s): Marie Wiatr, Maya Hadzhieva, Maxime Lecerf, Rémi Noé, Sune Justesen, Sébastien Lacroix-Desmazes , Marie-Agnès Dragon-Durey, Jordan D Dimitrov
Published in: International Journal of Molecular Sciences, Issue 24, 2023, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24043416

Functional Changes of Therapeutic Antibodies upon Exposure to Pro-Oxidative Agents

Author(s): Maxime Lecerf, Robin Lacombe, Alexia Kanyavuz, Jordan D Dimitrov
Published in: Antibodies (Basel), Issue 11, 2022, ISSN 2073-4468
Publisher: MDPI
DOI: 10.3390/antib11010011