PRINCIPLES OF AXIAL POLARITY-DRIVEN VASCULAR PATTERNING

Project Information

AXIAL.EC

Grant agreement ID: 679368

DOI 10.3030/679368

Project closed

EC signature date 23 February 2016

Start date 1 September 2016

End date 28 February 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 618 750,00

EU contribution € 1 618 750,00

Coordinated by

INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES
Portugal

Publications

Conference proceedings (2)

Synthetic Generation of 3D Microscopy Images using Generative Adversarial Networks

Author(s): Hemaxi Narotamo; Marie Ouarne; Claudio Areias Franco; Margarida Silveira
Published in: Annu Int Conf IEEE Eng Med Biol Soc., Issue 1, 2022, ISBN 978-1-7281-2782-8
Publisher: IEEE
DOI: 10.1109/embc48229.2022.9871631

Joint Segmentation and Pairing of Nuclei and Golgi in 3D Microscopy Images

Author(s): Hemaxi Narotamo, Marie Ouarné, Cláudio Areias Franco, Margarida Silveira
Published in: IEEE Engineering in Medicine & Biology Society (EMBC), Issue 43rd Annual International Conference, 2021, ISBN 978-1-7281-1179-7
Publisher: IEEE
DOI: 10.1109/embc46164.2021.9630362

Peer reviewed articles (20)

Phosphoinositide 3-Kinase–Regulated Pericyte Maturation Governs Vascular Remodeling

Author(s): Ana M. Figueiredo, Pilar Villacampa, Rodrigo Diéguez-Hurtado, Juan José Lozano, Piotr Kobialka, Ana Rosa Cortazar, Anabel Martinez-Romero, Ana Angulo-Urarte, Claudio A. Franco, Marc Claret, Ana María Aransay, Ralf H. Adams, Arkaitz Carracedo, Mariona Graupera
Published in: Circulation, Issue 142/7, 2020, Page(s) 688-704, ISSN 0009-7322
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.119.042354

Endothelial cells on the move: dynamics in vascular morphogenesis and disease

Author(s): Catarina G Fonseca, Pedro Barbacena, Claudio A Franco
Published in: Vascular Biology, Issue 2/1, 2020, Page(s) H29-H43, ISSN 2516-5658
Publisher: Bioscientifica
DOI: 10.1530/vb-20-0007

On the preservation of vessel bifurcations during flow-mediated angiogenic remodelling

Author(s): Lowell T. Edgar, Claudio A. Franco, Holger Gerhardt, Miguel O. Bernabeu
Published in: PLOS Computational Biology, Issue 17/2, 2021, Page(s) e1007715, ISSN 1553-7358
Publisher: PLOS
DOI: 10.1371/journal.pcbi.1007715

From remodeling to quiescence: The transformation of the vascular network

Author(s): Marie Ouarné, Andreia Pena, Cláudio Areias Franco
Published in: Cells & Development, 2021, Page(s) 203735, ISSN 2667-2901
Publisher: Cells & Development
DOI: 10.1016/j.cdev.2021.203735

Methods to quantify endothelial cell front-rear polarity in vivo and in vitro

Author(s): Andreia Pena, Marie Ouarné, Cláudio Areias Franco
Published in: Current Opinion in Hematology, Issue 28/3, 2021, Page(s) 208-213, ISSN 1065-6251
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/moh.0000000000000643

Immunopathology and Trypanosoma congolense parasite sequestration cause acute cerebral trypanosomiasis

Author(s): Mariana De Niz; Sara Silva Pereira; Karine Serre; Marie Ouarné; Joana E Coelho; Cláudio A Franco; Luisa M Figueiredo
Published in: eLIFE, Issue 1, 2022, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.77440

Endothelial cell invasion is controlled by dactylopodia

Author(s): Ana Martins Figueiredo, Pedro Barbacena, Ana Russo, Silvia Vaccaro, Daniela Ramalho, Andreia Pena, Aida Pires Lima, Rita Rua Ferreira, Marta Alves Fidalgo, Fatima El-Marjou, Yulia Carvalho, Francisca Ferreira Vasconcelos, Ana-Maria Lennon-Duménil, Danijela Matic Vignjevic, Claudio Areias Franco
Published in: Proceedings of the National Academy of Sciences, Issue 118/18, 2021, Page(s) e2023829118, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2023829118

Blood flow boosts BMP signaling to keep vessels in shape

Author(s): Claudio A. Franco, Holger Gerhardt
Published in: The Journal of Cell Biology, Issue 214/7, 2016, Page(s) 793-795, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.201609038

PAR‐3 controls endothelial planar polarity and vascular inflammation under laminar flow

Author(s): Takao Hikita, Fatemeh Mirzapourshafiyi, Pedro Barbacena, Meghan Riddell, Ayesha Pasha, Mengnan Li, Takuji Kawamura, Ralf P Brandes, Tomonori Hirose, Shigeo Ohno, Holger Gerhardt, Michiyuki Matsuda, Claudio A Franco, Masanori Nakayama
Published in: EMBO reports, 2018, Page(s) e45253, ISSN 1469-221X
Publisher: Nature Publishing Group
DOI: 10.15252/embr.201745253

YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development

Author(s): Filipa Neto, Alexandra Klaus-Bergmann, Yu Ting Ong, Silvanus Alt, Anne-Clémence Vion, Anna Szymborska, Joana R Carvalho, Irene Hollfinger, Eireen Bartels-Klein, Claudio A Franco, Michael Potente, Holger Gerhardt
Published in: eLife, Issue 7, 2018, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/eLife.31037

PolNet: A Tool to Quantify Network-Level Cell Polarity and Blood Flow in Vascular Remodeling

Author(s): Miguel O. Bernabeu, Martin L. Jones, Rupert W. Nash, Anna Pezzarossa, Peter V. Coveney, Holger Gerhardt, Claudio A. Franco
Published in: Biophysical Journal, Issue 114/9, 2018, Page(s) 2052-2058, ISSN 0006-3495
Publisher: Biophysical Society
DOI: 10.1016/j.bpj.2018.03.032

Computational fluid dynamics assisted characterization of parafoveal hemodynamics in normal and diabetic eyes using adaptive optics scanning laser ophthalmoscopy

Author(s): Yang Lu, Miguel O. Bernabeu, Jan Lammer, Charles C. Cai, Martin L. Jones, Claudio A. Franco, Lloyd Paul Aiello, Jennifer K. Sun
Published in: Biomedical Optics Express, Issue 7/12, 2016, Page(s) 4958, ISSN 2156-7085
Publisher: The Optical Society
DOI: 10.1364/BOE.7.004958

Endothelial Calcineurin Signaling Restrains Metastatic Outgrowth by Regulating Bmp2

Author(s): Stefanie Hendrikx, Sanja Coso, Borja Prat-Luri, Laureline Wetterwald, Amélie Sabine, Claudio A. Franco, Sina Nassiri, Nadine Zangger, Holger Gerhardt, Mauro Delorenzi, Tatiana V. Petrova
Published in: Cell Reports, Issue 26/5, 2019, Page(s) 1227-1241.e6, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.01.016

GNrep mouse: A reporter mouse for front–rear cell polarity

Author(s): Pedro Barbacena, Marie Ouarné, Jody J. Haigh, Francisca F. Vasconcelos, Anna Pezzarossa, Claudio A. Franco
Published in: genesis, 2019, Page(s) e23299, ISSN 1526-954X
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/dvg.23299

Non-canonical Wnt signaling regulates junctional mechanocoupling during angiogenic collective cell migration

Author(s): Joana R Carvalho, Isabela C Fortunato, Catarina G Fonseca, Anna Pezzarossa, Pedro Barbacena, Maria A Dominguez-Cejudo, Francisca F Vasconcelos, Nuno C Santos, Filomena A Carvalho, Claudio A Franco
Published in: eLife, Issue 8, 2019, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.45853

Competition for endothelial cell polarity drives vascular morphogenesis in the mouse retina

Author(s): Pedro Barbacena, Maria Dominguez-Cejudo, Catarina G Fonseca, Manuel Gómez-González, Laura M Faure, Georgia Zarkada, Andreia Pena, Anna Pezzarossa, Daniela Ramalho, Ylenia Giarratano, Marie Ouarné, David Barata, Isabela C Fortunato, Lenka Henao Misikova, Ian Mauldin, Yulia Carvalho , Xavier Trepat, Pere Roca-Cusachs, Anne Eichmann, Miguel O Bernabeu, Cláudio A Franco
Published in: Developmental Cell, 2022, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2022.09.002

Organotypic endothelial adhesion molecules are key for Trypanosoma brucei tropism and virulence

Author(s): Mariana De Niz, Daniela Brás, Marie Ouarné, Mafalda Pedro, Ana M. Nascimento, Lenka Henao Misikova, Claudio A. Franco, Luisa M. Figueiredo
Published in: Cell Reports, Issue 36/12, 2021, Page(s) 109741, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2021.109741

Mouse retinal cell behaviour in space and time using light sheet fluorescence microscopy

Author(s): Claudia Prahst, Parham Ashrafzadeh, Thomas Mead, Ana Figueiredo, Karen Chang, Douglas Richardson, Lakshmi Venkaraman, Mark Richards, Ana Martins Russo, Kyle Harrington, Marie Ouarné, Andreia Pena, Dong Feng Chen, Lena Claesson-Welsh, Kin-Sang Cho, Claudio A Franco, Katie Bentley
Published in: eLife, Issue 9, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.49779

Defective Flow-Migration Coupling Causes Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia

Author(s): Hyojin Park, Jessica Furtado, Mathilde Poulet, Minhwan Chung, Sanguk Yun, Sungwoon Lee, William C. Sessa, Claudio A. Franco, Martin A. Schwartz, Anne Eichmann
Published in: Circulation, Issue 144/10, 2021, Page(s) 805-822, ISSN 0009-7322
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.120.053047

Morph or Move? How Distinct Endothelial Cell Responses to Blood Flow Shape Vascular Networks

Author(s): Claudio A. Franco, Holger Gerhardt
Published in: Developmental Cell, Issue 41/6, 2017, Page(s) 574-576, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2017.06.008

Intellectual Property Rights

Patent (3)

GNREP MOUSE: A TRANSGENIC REPORTER MOUSE LINE FOR FRONT-REAR CELL POLARITY

Application/Publication number: 0198 20191000006333
Date: 2019-02-01

GNREP MOUSE: A TRANSGENIC REPORTER MOUSE LINE FOR FRONT-REAR CELL POLARITY

Application/Publication number: 0198 20191000006333
Date: 2019-02-01

GNREP MOUSE: A TRANSGENIC REPORTER MOUSE LINE FOR FRONT-REAR CELL POLARITY

Application/Publication number: 0198 20191000006333
Date: 2019-02-01
Applicant(s): INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES