PRINCIPLES OF AXIAL POLARITY-DRIVEN VASCULAR PATTERNING

Project Information

AXIAL.EC

Grant agreement ID: 679368

DOI

10.3030/679368

Project closed

EC signature date 23 February 2016

Start date 1 September 2016

End date 28 February 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 618 750,00

EU contribution

€ 1 618 750,00

Coordinated by

INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES
Portugal

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Conference proceedings (2)

Synthetic Generation of 3D Microscopy Images using Generative Adversarial Networks

Author(s): Hemaxi Narotamo; Marie Ouarne; Claudio Areias Franco; Margarida Silveira
Published in: Annu Int Conf IEEE Eng Med Biol Soc., Issue 1, 2022, ISBN 978-1-7281-2782-8
Publisher: IEEE
DOI: 10.1109/embc48229.2022.9871631

Joint Segmentation and Pairing of Nuclei and Golgi in 3D Microscopy Images

Author(s): Hemaxi Narotamo, Marie Ouarné, Cláudio Areias Franco, Margarida Silveira
Published in: IEEE Engineering in Medicine & Biology Society (EMBC), Issue 43rd Annual International Conference, 2021, ISBN 978-1-7281-1179-7
Publisher: IEEE
DOI: 10.1109/embc46164.2021.9630362

Peer reviewed articles (20)

Phosphoinositide 3-Kinase–Regulated Pericyte Maturation Governs Vascular Remodeling

Author(s): Ana M. Figueiredo, Pilar Villacampa, Rodrigo Diéguez-Hurtado, Juan José Lozano, Piotr Kobialka, Ana Rosa Cortazar, Anabel Martinez-Romero, Ana Angulo-Urarte, Claudio A. Franco, Marc Claret, Ana María Aransay, Ralf H. Adams, Arkaitz Carracedo, Mariona Graupera
Published in: Circulation, Issue 142/7, 2020, Page(s) 688-704, ISSN 0009-7322
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.119.042354

Endothelial cells on the move: dynamics in vascular morphogenesis and disease

Author(s): Catarina G Fonseca, Pedro Barbacena, Claudio A Franco
Published in: Vascular Biology, Issue 2/1, 2020, Page(s) H29-H43, ISSN 2516-5658
Publisher: Bioscientifica
DOI: 10.1530/vb-20-0007

On the preservation of vessel bifurcations during flow-mediated angiogenic remodelling

Author(s): Lowell T. Edgar, Claudio A. Franco, Holger Gerhardt, Miguel O. Bernabeu
Published in: PLOS Computational Biology, Issue 17/2, 2021, Page(s) e1007715, ISSN 1553-7358
Publisher: PLOS
DOI: 10.1371/journal.pcbi.1007715

From remodeling to quiescence: The transformation of the vascular network

Author(s): Marie Ouarné, Andreia Pena, Cláudio Areias Franco
Published in: Cells & Development, 2021, Page(s) 203735, ISSN 2667-2901
Publisher: Cells & Development
DOI: 10.1016/j.cdev.2021.203735

Methods to quantify endothelial cell front-rear polarity in vivo and in vitro

Author(s): Andreia Pena, Marie Ouarné, Cláudio Areias Franco
Published in: Current Opinion in Hematology, Issue 28/3, 2021, Page(s) 208-213, ISSN 1065-6251
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/moh.0000000000000643

Immunopathology and Trypanosoma congolense parasite sequestration cause acute cerebral trypanosomiasis

Author(s): Mariana De Niz; Sara Silva Pereira; Karine Serre; Marie Ouarné; Joana E Coelho; Cláudio A Franco; Luisa M Figueiredo
Published in: eLIFE, Issue 1, 2022, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.77440

Endothelial cell invasion is controlled by dactylopodia

Author(s): Ana Martins Figueiredo, Pedro Barbacena, Ana Russo, Silvia Vaccaro, Daniela Ramalho, Andreia Pena, Aida Pires Lima, Rita Rua Ferreira, Marta Alves Fidalgo, Fatima El-Marjou, Yulia Carvalho, Francisca Ferreira Vasconcelos, Ana-Maria Lennon-Duménil, Danijela Matic Vignjevic, Claudio Areias Franco
Published in: Proceedings of the National Academy of Sciences, Issue 118/18, 2021, Page(s) e2023829118, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2023829118

Blood flow boosts BMP signaling to keep vessels in shape

Author(s): Claudio A. Franco, Holger Gerhardt
Published in: The Journal of Cell Biology, Issue 214/7, 2016, Page(s) 793-795, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.201609038

PAR‐3 controls endothelial planar polarity and vascular inflammation under laminar flow

Author(s): Takao Hikita, Fatemeh Mirzapourshafiyi, Pedro Barbacena, Meghan Riddell, Ayesha Pasha, Mengnan Li, Takuji Kawamura, Ralf P Brandes, Tomonori Hirose, Shigeo Ohno, Holger Gerhardt, Michiyuki Matsuda, Claudio A Franco, Masanori Nakayama
Published in: EMBO reports, 2018, Page(s) e45253, ISSN 1469-221X
Publisher: Nature Publishing Group
DOI: 10.15252/embr.201745253

YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development

Author(s): Filipa Neto, Alexandra Klaus-Bergmann, Yu Ting Ong, Silvanus Alt, Anne-Clémence Vion, Anna Szymborska, Joana R Carvalho, Irene Hollfinger, Eireen Bartels-Klein, Claudio A Franco, Michael Potente, Holger Gerhardt
Published in: eLife, Issue 7, 2018, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/eLife.31037

PolNet: A Tool to Quantify Network-Level Cell Polarity and Blood Flow in Vascular Remodeling

Author(s): Miguel O. Bernabeu, Martin L. Jones, Rupert W. Nash, Anna Pezzarossa, Peter V. Coveney, Holger Gerhardt, Claudio A. Franco
Published in: Biophysical Journal, Issue 114/9, 2018, Page(s) 2052-2058, ISSN 0006-3495
Publisher: Biophysical Society
DOI: 10.1016/j.bpj.2018.03.032

Computational fluid dynamics assisted characterization of parafoveal hemodynamics in normal and diabetic eyes using adaptive optics scanning laser ophthalmoscopy

Author(s): Yang Lu, Miguel O. Bernabeu, Jan Lammer, Charles C. Cai, Martin L. Jones, Claudio A. Franco, Lloyd Paul Aiello, Jennifer K. Sun
Published in: Biomedical Optics Express, Issue 7/12, 2016, Page(s) 4958, ISSN 2156-7085
Publisher: The Optical Society
DOI: 10.1364/BOE.7.004958

Endothelial Calcineurin Signaling Restrains Metastatic Outgrowth by Regulating Bmp2

Author(s): Stefanie Hendrikx, Sanja Coso, Borja Prat-Luri, Laureline Wetterwald, Amélie Sabine, Claudio A. Franco, Sina Nassiri, Nadine Zangger, Holger Gerhardt, Mauro Delorenzi, Tatiana V. Petrova
Published in: Cell Reports, Issue 26/5, 2019, Page(s) 1227-1241.e6, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.01.016

GNrep mouse: A reporter mouse for front–rear cell polarity

Author(s): Pedro Barbacena, Marie Ouarné, Jody J. Haigh, Francisca F. Vasconcelos, Anna Pezzarossa, Claudio A. Franco
Published in: genesis, 2019, Page(s) e23299, ISSN 1526-954X
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/dvg.23299

Non-canonical Wnt signaling regulates junctional mechanocoupling during angiogenic collective cell migration

Author(s): Joana R Carvalho, Isabela C Fortunato, Catarina G Fonseca, Anna Pezzarossa, Pedro Barbacena, Maria A Dominguez-Cejudo, Francisca F Vasconcelos, Nuno C Santos, Filomena A Carvalho, Claudio A Franco
Published in: eLife, Issue 8, 2019, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.45853

Competition for endothelial cell polarity drives vascular morphogenesis in the mouse retina

Author(s): Pedro Barbacena, Maria Dominguez-Cejudo, Catarina G Fonseca, Manuel Gómez-González, Laura M Faure, Georgia Zarkada, Andreia Pena, Anna Pezzarossa, Daniela Ramalho, Ylenia Giarratano, Marie Ouarné, David Barata, Isabela C Fortunato, Lenka Henao Misikova, Ian Mauldin, Yulia Carvalho , Xavier Trepat, Pere Roca-Cusachs, Anne Eichmann, Miguel O Bernabeu, Cláudio A Franco
Published in: Developmental Cell, 2022, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2022.09.002

Organotypic endothelial adhesion molecules are key for Trypanosoma brucei tropism and virulence

Author(s): Mariana De Niz, Daniela Brás, Marie Ouarné, Mafalda Pedro, Ana M. Nascimento, Lenka Henao Misikova, Claudio A. Franco, Luisa M. Figueiredo
Published in: Cell Reports, Issue 36/12, 2021, Page(s) 109741, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2021.109741

Mouse retinal cell behaviour in space and time using light sheet fluorescence microscopy

Author(s): Claudia Prahst, Parham Ashrafzadeh, Thomas Mead, Ana Figueiredo, Karen Chang, Douglas Richardson, Lakshmi Venkaraman, Mark Richards, Ana Martins Russo, Kyle Harrington, Marie Ouarné, Andreia Pena, Dong Feng Chen, Lena Claesson-Welsh, Kin-Sang Cho, Claudio A Franco, Katie Bentley
Published in: eLife, Issue 9, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.49779

Defective Flow-Migration Coupling Causes Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia

Author(s): Hyojin Park, Jessica Furtado, Mathilde Poulet, Minhwan Chung, Sanguk Yun, Sungwoon Lee, William C. Sessa, Claudio A. Franco, Martin A. Schwartz, Anne Eichmann
Published in: Circulation, Issue 144/10, 2021, Page(s) 805-822, ISSN 0009-7322
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.120.053047

Morph or Move? How Distinct Endothelial Cell Responses to Blood Flow Shape Vascular Networks

Author(s): Claudio A. Franco, Holger Gerhardt
Published in: Developmental Cell, Issue 41/6, 2017, Page(s) 574-576, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2017.06.008

Intellectual Property Rights

Patent (1)

GNREP MOUSE: A TRANSGENIC REPORTER MOUSE LINE FOR FRONT-REAR CELL POLARITY

Application/Publication number: 0198 20191000006333
Date: 2019-02-01
Applicant(s): INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES