The Pancreas Regulome: From causality to prediction of non-coding mutations in human pancreatic diseases

Project Information

ZPR

Grant agreement ID: 680156

DOI

10.3030/680156

Project closed

EC signature date 21 April 2016

Start date 1 June 2016

End date 31 December 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 497 520,00

EU contribution

€ 1 497 520,00

Coordinated by

INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR-IBMC
Portugal

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (10)

Multidimensional chromatin profiling of zebrafish pancreas to uncover and investigate disease-relevant enhancers

Author(s): R. Bordeira-Carriço, J. Teixeira, M. Duque, M. Galhardo, D. Ribeiro, R. Dominguez-Acemel, P. N. Firbas, J. J. Tena, A. Eufrasio, J. Marques, F. Ferreira, T. Freitas, F. Carneiro, J. L. Goméz-Skarmeta, J. Bessa
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group

FOXM1 repression increases mitotic death upon antimitotic chemotherapy through BMF upregulation

Author(s): Sara Vaz, Fábio J. Ferreira, Joana C. Macedo, Gil Leor, Uri Ben-David, José Bessa, Elsa Logarinho
Published in: Cell Death & Disease, 2021, ISSN 2041-4889
Publisher: Nature Publishing Group
DOI: 10.1038/s41419-021-03822-5

Glycans as Immune Checkpoints: Removal of Branched N-glycans Enhances Immune Recognition Preventing Cancer Progression

Author(s): Mariana C. Silva, Ângela Fernandes, Maria Oliveira, Carlos Resende, Alexandra Correia, Julio C. de-Freitas-Junior, Aonghus Lavelle, Jéssica Andrade-da-Costa, Magdalena Leander, Helena Xavier-Ferreira, José Bessa, Carina Pereira, Rui M. Henrique, Fátima Carneiro, Mário Dinis-Ribeiro, Ricardo Marcos-Pinto, Margarida Lima, Bernd Lepenies, Harry Sokol, José C. Machado, Manuel Vilanova, Salomé S
Published in: Cancer Immunology Research, Issue 8/11, 2020, Page(s) 1407-1425, ISSN 2326-6066
Publisher: American Association for Cancer Research Inc.
DOI: 10.1158/2326-6066.cir-20-0264

A Conserved Notochord Enhancer Controls Pancreas Development in Vertebrates

Author(s): João Pedro Amorim, Ana Gali-Macedo, Hugo Marcelino, Renata Bordeira-Carriço, Silvia Naranjo, Solangel Rivero-Gil, Joana Teixeira, Mafalda Galhardo, Joana Marques, José Bessa
Published in: Cell Reports, Issue 32/1, 2020, Page(s) 107862, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.107862

foxm1 Modulates Cell Non-Autonomous Response in Zebrafish Skeletal Muscle Homeostasis

Author(s): Fábio J Ferreira; Leonor Carvalho; Leonor Carvalho; Leonor Carvalho; Elsa Logarinho; Elsa Logarinho; José Bessa; José Bessa
Published in: Cells, Issue 1, 2021, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells10051241

Antisense Transcription across Nucleotide Repeat Expansions in Neurodegenerative and Neuromuscular Diseases: Progress and Mysteries

Author(s): Ana F. Castro, Joana R. Loureiro, José Bessa, Isabel Silveira
Published in: Genes, Issue 11/12, 2020, Page(s) 1418, ISSN 2073-4425
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes11121418

In Vivo Reporter Assays Uncover Changes in Enhancer Activity Caused by Type 2 Diabetes–Associated Single Nucleotide Polymorphisms

Author(s): Ana Eufrásio, Chiara Perrod, Fábio J. Ferreira, Marta Duque, Mafalda Galhardo, José Bessa
Published in: Diabetes, Issue 69/12, 2020, Page(s) 2794-2805, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/db19-1049

Ptf1a function and transcriptional cis-regulation, a cornerstone in vertebrate pancreas development.

Author(s): Marta Duque; Marta Duque; João Amorim; João Amorim; José Bessa; José Bessa
Published in: FEBS, Issue 1, 2021, ISSN 1742-464X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/febs.16075

CRISPR-Cas9-Mediated Genomic Deletions Protocol in Zebrafish

Author(s): João Pedro Amorim, Renata Bordeira-Carriço, Ana Gali-Macedo, Chiara Perrod, José Bessa
Published in: STAR Protocols, Issue 1/3, 2020, Page(s) 100208, ISSN 2666-1667
Publisher: Cell Press
DOI: 10.1016/j.xpro.2020.100208

Intratumoral VEGF nanotrapper reduces gliobastoma vascularization and tumor cell mass

Author(s): Flávia Sousa; Ana Isabel Costa-Pereira; Andrea Cruz; Fábio J Ferreira; Marcos Gouveia; José Bessa; Bruno Sarmento; Rui D. M. Travasso; I Pinto
Published in: Journal of Controlled Release, Issue 1, 2021, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2021.09.031

Thesis and dissertations (4)

Study of human regulatory mutations associated with pancreatic diseases by humanizing the zebrafish genome.

Author(s): Inês Maria Batista da Costa
Published in: University of Oporto, Issue 1, 2019
Publisher: Universidade do Porto

Crispr-cas9 mutagenesis of the zebrafish foxm1

Author(s): Carvalho, Leonor
Published in: University of Lisbon, 2018
Publisher: Universidade de Lisboa, Faculdade de Ciências

Uncovering transcriptional cisregulatory  elements active in zebrafish adult exocrine pancreas

Author(s): Diogo José Coutinho Ribeiro
Published in: University of Oporto, Issue 1, 2018
Publisher: Universidade do Porto

O potencial regulatório em cis de sequências não codificantes associadas a diabetes tipo 2

Author(s): Eufrásio, Ana Catarina Macedo
Published in: University of Aveiro, Issue 1, 2018
Publisher: Universidade de Aveiro

Other (1)

Cis-regulatory similarities in the zebrafish and human pancreas uncover potential disease-related enhancers

Author(s): R. Bordeira-Carriço ; J. Teixeira ; M. Duque ; M. Galhardo ; D. Ribeiro ; R. Dominguez-Acemel ; P. N. Firbas ; J. J. Tena ; A. Eufrasio; J. Marques ; F. Ferreira ; T. Freitas ; F. Carneiro ; J. L. Goméz-Skarmeta ; J. Bessa
Published in: Biorxvi, 2020
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/2020.04.27.064220

Non-peer reviewed articles (1)

A master cis-regulatory element in the FOXM1/RHNO1/TEAD4 landscape drives cellular senescence

Author(s): Fábio Júnio Ferreira, Joana Teixeira, Mafalda Galhardo, Elsa Logarinho, José Bessa
Published in: Genome Biology, 2022, ISSN 1474-760X
Publisher: BioMed Central