Highly Competent and Safe Titanium(IV) Therapeutic Frameworks that are Cancer Targeted based on Complex 1, 2, and 3D Chemical Architectures

Project Information

TiDrugArchitectures

Grant agreement ID: 681243

DOI 10.3030/681243

Project closed

EC signature date 25 May 2016

Start date 1 June 2016

End date 31 May 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 000 000,00

EU contribution € 2 000 000,00

Coordinated by

THE HEBREW UNIVERSITY OF JERUSALEM
Israel

Publications

Peer reviewed articles (8)

Binding of the anticancer Ti(IV) complex phenolaTi to serum proteins: Thermodynamic and kinetic aspects

Author(s): Zohar Shpilt, Edit Y. Tshuva
Published in: Journal of Inorganic Biochemistry, 2022, ISSN 0162-0134
Publisher: Elsevier BV
DOI: 10.1016/j.jinorgbio.2022.111817

Titanium Tackles the Endoplasmic Reticulum: A First Genomic Study on a Titanium Anticancer Metallodrug

Author(s): Maya Miller, Anna Mellul, Maya Braun, Dana Sherill-Rofe, Emiliano Cohen, Zohar Shpilt, Irene Unterman, Ori Braitbard, Jacob Hochman, Edit Y. Tshuva, Yuval Tabach
Published in: iScience, 2020, ISSN 2589-0042
Publisher: Science Direct
DOI: 10.1016/j.isci.2020.101262

Fluorescent antitumor titanium( iv ) salen complexes for cell imaging

Author(s): Avia Tzubery, Naomi Melamed-Book, Edit Y. Tshuva
Published in: Dalton Transactions, Issue 47/11, 2018, Page(s) 3669-3673, ISSN 1477-9226
Publisher: Royal Society of Chemistry
DOI: 10.1039/c7dt04828a

In Vivo Anticancer Activity of a Nontoxic Inert Phenolato Titanium Complex: High Efficacy on Solid Tumors Alone and Combined with Platinum Drugs

Author(s): Nitzan Ganot, Ori Briaitbard, Asaad Gammal, Joseph Tam, Jacob Hochman, Edit Y. Tshuva
Published in: ChemMedChem, Issue 13/21, 2018, Page(s) 2290-2296, ISSN 1860-7179
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.201800551

Cytotoxic Titanium(IV) Complexes of Salalen-Based Ligands

Author(s): Avia Tzubery, Edit Y. Tshuva
Published in: European Journal of Inorganic Chemistry, Issue 2017/12, 2017, Page(s) 1695-1705, ISSN 1434-1948
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/ejic.201601200

Racemic vs. enantiopure inert Ti( iv ) complex of a single diaminotetrakis(phenolato) ligand in anticancer activity toward human drug-sensitive and -resistant cancer cell lines

Author(s): Maya Miller, Edit Y. Tshuva
Published in: RSC Advances, Issue 8/69, 2018, Page(s) 39731-39734, ISSN 2046-2069
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8ra08925f

From medium to endoplasmic reticulum: Tracing anticancer phenolato titanium(IV) complex by 19F NMR detection

Author(s): Gilad Nahari, Roy E. Hoffman, Edit Y. Tshuva
Published in: Journal of Inorganic Biochemistry, 2021, ISSN 0162-0134
Publisher: Elsevier BV
DOI: 10.1016/j.jinorgbio.2021.111492

Effective Oral Administration of an AntitumorigenicNanoformulated Titanium Complex

Author(s): Gilad Nahari, Ori Braitbard, Liraz Larush, Jacob Hochman, Edit Y. Tshuva
Published in: ChemMedChem, 2021, ISSN 1860-7187
Publisher: Wiley
DOI: 10.1002/cmdc.202000384