Structural basis for the coordination of chromosome architecture by condensin complexes

Project Information

CondStruct

Grant agreement ID: 681365

DOI

10.3030/681365

Project closed

EC signature date 9 June 2016

Start date 1 July 2016

End date 31 December 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 982 479,00

EU contribution

€ 1 982 479,00

Coordinated by

JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (11)

Structural insights into DNA loop extrusion by SMC protein complexes

Author(s): Sumanjit Datta, Léa Lecomte, Christian H Haering
Published in: Current Opinion in Structural Biology, Issue 65, 2020, Page(s) 102-109, ISSN 0959-440X
Publisher: Elsevier BV
DOI: 10.1016/j.sbi.2020.06.009

Real‐time detection of condensin‐driven DNA compaction reveals a multistep binding mechanism

Author(s): Jorine M Eeftens, Shveta Bisht, Jacob Kerssemakers, Marc Kschonsak, Christian H Haering, Cees Dekker
Published in: The EMBO Journal, Issue 36/23, 2017, Page(s) 3448-3457, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.201797596

The condensin complex is a mechanochemical motor that translocates along DNA

Author(s): Tsuyoshi Terakawa, Shveta Bisht, Jorine M. Eeftens, Cees Dekker, Christian H. Haering, Eric C. Greene
Published in: Science, Issue 358/6363, 2017, Page(s) 672-676, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aan6516

Structural Basis for a Safety-Belt Mechanism That Anchors Condensin to Chromosomes

Author(s): Marc Kschonsak, Fabian Merkel, Shveta Bisht, Jutta Metz, Vladimir Rybin, Markus Hassler, Christian H. Haering
Published in: Cell, Issue 171/3, 2017, Page(s) 588-600.e24, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2017.09.008

Real-time imaging of DNA loop extrusion by condensin

Author(s): Mahipal Ganji, Indra A. Shaltiel, Shveta Bisht, Eugene Kim, Ana Kalichava, Christian H. Haering, Cees Dekker
Published in: Science, Issue 360/6384, 2018, Page(s) 102-105, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aar7831

Structural Basis of an Asymmetric Condensin ATPase Cycle

Author(s): Markus Hassler, Indra A. Shaltiel, Marc Kschonsak, Bernd Simon, Fabian Merkel, Lena Thärichen, Henry J. Bailey, Jakub Macošek, Sol Bravo, Jutta Metz, Janosch Hennig, Christian H. Haering
Published in: Molecular Cell, Issue 74/6, 2019, Page(s) 1175-1188.e9, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2019.03.037

Distinct Roles for Condensin’s Two ATPase Sites in Chromosome Condensation

Author(s): Ahmed M.O. Elbatsh, Eugene Kim, Jorine M. Eeftens, Jonne A. Raaijmakers, Robin H. van der Weide, Alberto García-Nieto, Sol Bravo, Mahipal Ganji, Jelmi uit de Bos, Hans Teunissen, René H. Medema, Elzo de Wit, Christian H. Haering, Cees Dekker, Benjamin D. Rowland
Published in: Molecular Cell, Issue 76/5, 2019, Page(s) 724-737.e5, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2019.09.020

Solution structure and flexibility of the condensin HEAT-repeat subunit Ycg1

Author(s): Karen Manalastas-Cantos, Marc Kschonsak, Christian H. Haering, Dmitri I. Svergun
Published in: Journal of Biological Chemistry, Issue 294/37, 2019, Page(s) 13822-13829, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra119.008661

Cryo-EM structures of holo condensin reveal a subunit flip-flop mechanism

Author(s): Byung-Gil Lee, Fabian Merkel, Matteo Allegretti, Markus Hassler, Christopher Cawood, Léa Lecomte, Francis J. O’Reilly, Ludwig R. Sinn, Pilar Gutierrez-Escribano, Marc Kschonsak, Sol Bravo, Takanori Nakane, Juri Rappsilber, Luis Aragon, Martin Beck, Jan Löwe, Christian H. Haering
Published in: Nature Structural & Molecular Biology, Issue 27, 2020, Page(s) 743–751, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1038/s41594-020-0457-x

DNA-loop extruding condensin complexes can traverse one another

Author(s): Eugene Kim, Jacob Kerssemakers, Indra A. Shaltiel, Christian H. Haering, Cees Dekker
Published in: Nature, Issue 579/7799, 2020, Page(s) 438-442, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2067-5

Towards a Unified Model of SMC Complex Function

Author(s): Markus Hassler, Indra A. Shaltiel, Christian H. Haering
Published in: Current Biology, Issue 28/21, 2018, Page(s) R1266-R1281, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2018.08.034

Other (1)

A hold-and-feed mechanism drives directional DNA loop extrusion by condensin

Author(s): Indra A. Shaltiel, Sumanjit Datta, Léa Lecomte, Markus Hassler, Marc Kschonsak, Sol Bravo, Catherine Stober,Sebastian Eustermann, Christian H. Haering
Published in: bioRxiv preprint, 2021
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2021.10.29.466147