Structural basis for the coordination of chromosome architecture by condensin complexes

Project Information

CondStruct

Grant agreement ID: 681365

DOI 10.3030/681365

Project closed

EC signature date 9 June 2016

Start date 1 July 2016

End date 31 December 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 982 479,00

EU contribution € 1 982 479,00

Coordinated by

JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG
Germany

Publications

Peer reviewed articles (11)

Structural insights into DNA loop extrusion by SMC protein complexes

Author(s): Sumanjit Datta, Léa Lecomte, Christian H Haering
Published in: Current Opinion in Structural Biology, Issue 65, 2020, Page(s) 102-109, ISSN 0959-440X
Publisher: Elsevier BV
DOI: 10.1016/j.sbi.2020.06.009

Real‐time detection of condensin‐driven DNA compaction reveals a multistep binding mechanism

Author(s): Jorine M Eeftens, Shveta Bisht, Jacob Kerssemakers, Marc Kschonsak, Christian H Haering, Cees Dekker
Published in: The EMBO Journal, Issue 36/23, 2017, Page(s) 3448-3457, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.201797596

The condensin complex is a mechanochemical motor that translocates along DNA

Author(s): Tsuyoshi Terakawa, Shveta Bisht, Jorine M. Eeftens, Cees Dekker, Christian H. Haering, Eric C. Greene
Published in: Science, Issue 358/6363, 2017, Page(s) 672-676, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aan6516

Structural Basis for a Safety-Belt Mechanism That Anchors Condensin to Chromosomes

Author(s): Marc Kschonsak, Fabian Merkel, Shveta Bisht, Jutta Metz, Vladimir Rybin, Markus Hassler, Christian H. Haering
Published in: Cell, Issue 171/3, 2017, Page(s) 588-600.e24, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2017.09.008

Real-time imaging of DNA loop extrusion by condensin

Author(s): Mahipal Ganji, Indra A. Shaltiel, Shveta Bisht, Eugene Kim, Ana Kalichava, Christian H. Haering, Cees Dekker
Published in: Science, Issue 360/6384, 2018, Page(s) 102-105, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aar7831

Structural Basis of an Asymmetric Condensin ATPase Cycle

Author(s): Markus Hassler, Indra A. Shaltiel, Marc Kschonsak, Bernd Simon, Fabian Merkel, Lena Thärichen, Henry J. Bailey, Jakub Macošek, Sol Bravo, Jutta Metz, Janosch Hennig, Christian H. Haering
Published in: Molecular Cell, Issue 74/6, 2019, Page(s) 1175-1188.e9, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2019.03.037

Distinct Roles for Condensin’s Two ATPase Sites in Chromosome Condensation

Author(s): Ahmed M.O. Elbatsh, Eugene Kim, Jorine M. Eeftens, Jonne A. Raaijmakers, Robin H. van der Weide, Alberto García-Nieto, Sol Bravo, Mahipal Ganji, Jelmi uit de Bos, Hans Teunissen, René H. Medema, Elzo de Wit, Christian H. Haering, Cees Dekker, Benjamin D. Rowland
Published in: Molecular Cell, Issue 76/5, 2019, Page(s) 724-737.e5, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2019.09.020

Solution structure and flexibility of the condensin HEAT-repeat subunit Ycg1

Author(s): Karen Manalastas-Cantos, Marc Kschonsak, Christian H. Haering, Dmitri I. Svergun
Published in: Journal of Biological Chemistry, Issue 294/37, 2019, Page(s) 13822-13829, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra119.008661

Cryo-EM structures of holo condensin reveal a subunit flip-flop mechanism

Author(s): Byung-Gil Lee, Fabian Merkel, Matteo Allegretti, Markus Hassler, Christopher Cawood, Léa Lecomte, Francis J. O’Reilly, Ludwig R. Sinn, Pilar Gutierrez-Escribano, Marc Kschonsak, Sol Bravo, Takanori Nakane, Juri Rappsilber, Luis Aragon, Martin Beck, Jan Löwe, Christian H. Haering
Published in: Nature Structural & Molecular Biology, 2020, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1038/s41594-020-0457-x

DNA-loop extruding condensin complexes can traverse one another

Author(s): Eugene Kim, Jacob Kerssemakers, Indra A. Shaltiel, Christian H. Haering, Cees Dekker
Published in: Nature, Issue 579/7799, 2020, Page(s) 438-442, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2067-5

Towards a Unified Model of SMC Complex Function

Author(s): Markus Hassler, Indra A. Shaltiel, Christian H. Haering
Published in: Current Biology, Issue 28/21, 2018, Page(s) R1266-R1281, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2018.08.034

Other (1)

A hold-and-feed mechanism drives directional DNA loop extrusion by condensin

Author(s): Indra A. Shaltiel, Sumanjit Datta, Léa Lecomte, Markus Hassler, Marc Kschonsak, Sol Bravo, Catherine Stober,Sebastian Eustermann, Christian H. Haering
Published in: bioRxiv preprint, 2021
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2021.10.29.466147