CRACKING THE CODE BEHIND MITOTIC FIDELITY: the roles of tubulin post-translational modifications and a chromosome separation checkpoint

Project Information

CODECHECK

Grant agreement ID: 681443

DOI 10.3030/681443

Project closed

EC signature date 19 July 2016

Start date 1 July 2016

End date 30 June 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 323 468,00

EU contribution € 2 323 468,00

Coordinated by

INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR-IBMC
Portugal

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (31)

The Tubulin Code in Mitosis and Cancer

Author(s): Danilo Lopes, Helder Maiato
Published in: Cells, Issue 9/11, 2020, Page(s) 2356, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells9112356

CLASP2 recognizes tubulins exposed at the microtubule plus-end in a nucleotide state-sensitive manner

Author(s): Wangxi Luo, Vladimir Demidov, Qi Shen, Hugo Girão, Manas Chakraborty, Aleksandr Maiorov, Fazly I Ataullakhanov, Chenxiang Lin, Helder Maiato, Ekaterina L Grishchuk
Published in: Sci Adv, 2023, ISSN 2375-2548
Publisher: AAAS
DOI: 10.1126/sciadv.abq5404

Nuclear tension controls mitotic entry by regulating cyclin B1 nuclear translocation

Author(s): Margarida Dantas; Andreia Oliveira; Paulo Aguiar; Helder Maiato; Jorge G. Ferreira
Published in: Journal of Cell Biology, Issue 1, 2022, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.202205051

An anaphase surveillance mechanism prevents micronuclei formation from frequent chromosome segregation errors

Author(s): Bernardo Orr, Filipe De Sousa, Margarida A. Gomes, Olga Afonso, Ana Luisa Ferreira, Ana C. Figueiredo, Helder Maiato
Published in: Cell Reports, 2021, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2021.109783

Micronuclei from misaligned chromosomes that satisfy the spindle assembly checkpoint in cancer cells

Author(s): Ana M. Gomes, Bernardo Orr, Marco Novais-Cruz, Filipe De Sousa, Joana Macário-Monteiro, Carolina Lemos, Cristina Ferrás, Helder Maiato
Published in: Current Biology, 2022, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2022.08.026

α-tubulin detyrosination links the suppression of MCAK activity with taxol cytotoxicity

Author(s): Danilo Lopes, Alexandre L. Seabra, Bernardo Orr, Helder Maiato
Published in: Journal of Cell Biology, 2022, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.202205092

Polycomb group (PcG) proteins prevent the assembly of abnormal synaptonemal complex structures during meiosis

Author(s): Tália Feijão, Bruno Marques, Rui D Silva, Célia Carvalho, Daniel Sobral, Ricardo Matos, Tian Tan, António Pereira, Eurico Morais-de-Sá, Hélder Maiato, Steven Z DeLuca, Rui Gonçalo Martinho
Published in: PNAS, 2022, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2204701119

Microtubule poleward flux in human cells is driven by the coordinated action of four kinesins

Author(s): Yulia Steblyanko, Girish Rajendraprasad, Mariana Osswald, Susana Eibes, Ariana Jacome, Stephan Geley, António J Pereira, Helder Maiato, Marin Barisic
Published in: EMBO J, 2020, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2020105432

Augmin-dependent microtubule self-organization drives kinetochore fiber maturation in mammals

Author(s): Ana C. Almeida, Joana Soares-de-Oliveira, Danica Drpic, Liam P. Cheeseman, Joana Damas, Harris, A. Lewin, Denis Larkin, Paulo Aguiar, António J. Pereira, Helder Maiato
Published in: Cell Reports, 2022, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2022.110610

α-Tubulin detyrosination impairs mitotic error correction by suppressing MCAK centromeric activity

Author(s): Luísa T. Ferreira, Bernardo Orr, Girish Rajendraprasad, António J. Pereira, Carolina Lemos, Joana T. Lima, Clàudia Guasch Boldú, Jorge G. Ferreira, Marin Barisic, Helder Maiato
Published in: Journal of Cell Biology, Issue 219/4, 2020, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.201910064

Optimized protocol for live-cell analysis of kinetochore fiber maturation in Indian muntjac cells

Author(s): Ana C. Almeida, Joana Soares-de-Oliveira, Helder Maiato
Published in: STAR Protocols, 2023, ISSN 2666-1667
Publisher: Elsevier
DOI: 10.1016/j.xpro.2022.102011

Double-checking chromosome segregation

Author(s): Helder Maiato; Sónia Silva
Published in: Journal of Cell Biology, Issue 1, 2023, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.202301106

Mechanisms of Chromosome Congression during Mitosis

Author(s): Helder Maiato, Ana Gomes, Filipe Sousa, Marin Barisic
Published in: Biology, Issue 6/4, 2017, Page(s) 13, ISSN 2079-7737
Publisher: MDPI AG
DOI: 10.3390/biology6010013

Cell Division: NuMA Bears the Load in the Spindle

Author(s): Helder Maiato, António J. Pereira
Published in: Current Biology, Issue 27/15, 2017, Page(s) R765-R767, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2017.06.060

Protein Phosphatase 1 inactivates Mps1 to ensure efficient Spindle Assembly Checkpoint silencing

Author(s): Margarida Moura, Mariana Osswald, Nelson Leça, João Barbosa, António J Pereira, Helder Maiato, Claudio E Sunkel, Carlos Conde
Published in: eLife, Issue 6, 2017, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/eLife.25366

Chromosome Segregation Is Biased by Kinetochore Size

Author(s): Danica Drpic, Ana C. Almeida, Paulo Aguiar, Fioranna Renda, Joana Damas, Harris A. Lewin, Denis M. Larkin, Alexey Khodjakov, Helder Maiato
Published in: Current Biology, 2018, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2018.03.023

Closing the tubulin detyrosination cycle

Author(s): Anna Akhmanova, Helder Maiato
Published in: Science, Issue 358/6369, 2017, Page(s) 1381-1382, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aar3895

Chromokinesins

Author(s): Ana C. Almeida, Helder Maiato
Published in: Current Biology, Issue 28/19, 2018, Page(s) R1131-R1135, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2018.07.017

Differential regulation of transition zone and centriole proteins contributes to ciliary base diversity

Author(s): Swadhin Chandra Jana, Susana Mendonça, Pedro Machado, Sascha Werner, Jaqueline Rocha, António Pereira, Helder Maiato, Mónica Bettencourt-Dias
Published in: Nature Cell Biology, Issue 20/8, 2018, Page(s) 928-941, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-018-0132-1

Actin divides to conquer

Author(s): Helder Maiato, Cristina Ferrás
Published in: Science, Issue 357/6353, 2017, Page(s) 756-757, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aao2461

A Regulatory Switch Alters Chromosome Motions at the Metaphase-to-Anaphase Transition

Author(s): Kuan-Chung Su, Zachary Barry, Nina Schweizer, Helder Maiato, Mark Bathe, Iain McPherson Cheeseman
Published in: Cell Reports, Issue 17/7, 2016, Page(s) 1728-1738, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2016.10.046

The Tubulin Code: A Navigation System for Chromosomes during Mitosis

Author(s): Marin Barisic, Helder Maiato
Published in: Trends in Cell Biology, Issue 26/10, 2016, Page(s) 766-775, ISSN 0962-8924
Publisher: Elsevier BV
DOI: 10.1016/j.tcb.2016.06.001

Mitotic progression, arrest, exit or death relies on centromere structural integrity, rather than de novo transcription

Author(s): Marco Novais-Cruz, Maria Alba Abad, Wilfred FJ van IJcken, Niels Galjart, A Arockia Jeyaprakash, Helder Maiato, Cristina Ferrás
Published in: eLife, Issue 7, 2018, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.36898

Kinetochore regulation: Let there be light

Author(s): Ana C Figueiredo, Helder Maiato
Published in: Nature Chemical Biology, Issue 13/10, 2017, Page(s) 1058-1059, ISSN 1552-4450
Publisher: Nature Publishing Group
DOI: 10.1038/nchembio.2464

No chromosome left behind: The importance of metaphase alignment for mitotic fidelity

Author(s): Bernardo Orr, Helder Maiato
Published in: The Journal of Cell Biology, 2019, Page(s) jcb.201902041, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.201902041

Coherent-hybrid STED: high contrast sub-diffraction imaging using a bi-vortex depletion beam

Author(s): António Pereira, Mafalda Sousa, Ana C. Almeida, Luísa T. Ferreira, Ana Rita Costa, Marco Novais-Cruz, Cristina Ferrás, Mónica Mendes Sousa, Paula Sampaio, Michael Belsley, Helder Maiato
Published in: Optics Express, Issue 27/6, 2019, Page(s) 8092, ISSN 1094-4087
Publisher: Optical Society of America
DOI: 10.1364/oe.27.008092

Spatiotemporal control of mitotic exit during anaphase by an aurora B-Cdk1 crosstalk

Author(s): Olga Afonso, Colleen M Castellani, Liam P Cheeseman, Jorge G Ferreira, Bernardo Orr, Luisa T Ferreira, James J Chambers, Eurico Morais-de-Sá, Thomas J Maresca, Helder Maiato
Published in: eLife, Issue 8, 2019, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.47646

CLASP2 binding to curved microtubule tips promotes flux and stabilizes kinetochore attachments

Author(s): Hugo Girão, Naoyuki Okada, Tony A. Rodrigues, Alexandra O. Silva, Ana C. Figueiredo, Zaira Garcia, Tatiana Moutinho-Santos, Ikuko Hayashi, Jorge E. Azevedo, Sandra Macedo-Ribeiro, Helder Maiato
Published in: The Journal of Cell Biology, 2019, Page(s) jcb.201905080, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.201905080

SOGA1 and SOGA2/MTCL1 are CLASP-interacting proteins required for faithful chromosome segregation in human cells

Author(s): Luisa T. Ferreira, Elsa Logarinho, Joana C. Macedo, Ana R. R. Maia, Helder Maiato.
Published in: Chromosome Research, 2021, ISSN 0967-3849
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10577-021-09651-8

Mitotic DNA damage promotes chromokinesin-mediated missegregation of polar chromosomes in cancer cells

Author(s): Marco Novais-Cruz, Antonio Pombinho, Mafalda Sousa, Andre F. Maia, Helder Maiato, Cristina Ferras
Published in: Molecular Biology of the Cell, Issue 5, 2023, ISSN 1059-1524
Publisher: American Society for Cell Biology
DOI: 10.1091/mbc.e22-11-0518

Centrosome-nuclear axis repositioning drives the assembly of a bipolar spindle scaffold to ensure mitotic fidelity

Author(s): Vanessa Nunes, Margarida Dantas, Domingos Castro, Elisa Vitiello, Irène Wang, Nicolas Carpi, Martial Balland, Matthieu Piel, Paulo Aguiar, Helder Maiato, Jorge G. Ferreira
Published in: Molecular Biology of the Cell, 2020, ISSN 1059-1524
Publisher: American Society for Cell Biology
DOI: 10.1091/mbc.e20-01-0047

Book chapters (1)

Dissecting the role of the tubulin code in mitosis

Author(s): Luísa T. Ferreira, Ana C. Figueiredo, Bernardo Orr, Danilo Lopes, Helder Maiato
Published in: Mitosis and Meiosis Part A, Issue 144, 2018, Page(s) 33-74, ISBN 9780-128141441
Publisher: Elsevier
DOI: 10.1016/bs.mcb.2018.03.040