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CRACKING THE CODE BEHIND MITOTIC FIDELITY: the roles of tubulin post-translational modifications and a chromosome separation checkpoint

Publications

The Tubulin Code in Mitosis and Cancer

Author(s): Danilo Lopes, Helder Maiato
Published in: Cells, Issue 9/11, 2020, Page(s) 2356, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells9112356

CLASP2 recognizes tubulins exposed at the microtubule plus-end in a nucleotide state-sensitive manner

Author(s): Wangxi Luo, Vladimir Demidov, Qi Shen, Hugo Girão, Manas Chakraborty, Aleksandr Maiorov, Fazly I Ataullakhanov, Chenxiang Lin, Helder Maiato, Ekaterina L Grishchuk
Published in: Sci Adv, 2023, ISSN 2375-2548
Publisher: AAAS
DOI: 10.1126/sciadv.abq5404

Nuclear tension controls mitotic entry by regulating cyclin B1 nuclear translocation

Author(s): Margarida Dantas; Andreia Oliveira; Paulo Aguiar; Helder Maiato; Jorge G. Ferreira
Published in: Journal of Cell Biology, Issue 1, 2022, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.202205051

An anaphase surveillance mechanism prevents micronuclei formation from frequent chromosome segregation errors

Author(s): Bernardo Orr, Filipe De Sousa, Margarida A. Gomes, Olga Afonso, Ana Luisa Ferreira, Ana C. Figueiredo, Helder Maiato
Published in: Cell Reports, 2021, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2021.109783

Micronuclei from misaligned chromosomes that satisfy the spindle assembly checkpoint in cancer cells

Author(s): Ana M. Gomes, Bernardo Orr, Marco Novais-Cruz, Filipe De Sousa, Joana Macário-Monteiro, Carolina Lemos, Cristina Ferrás, Helder Maiato
Published in: Current Biology, 2022, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2022.08.026

α-tubulin detyrosination links the suppression of MCAK activity with taxol cytotoxicity

Author(s): Danilo Lopes, Alexandre L. Seabra, Bernardo Orr, Helder Maiato
Published in: Journal of Cell Biology, 2022, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.202205092

Polycomb group (PcG) proteins prevent the assembly of abnormal synaptonemal complex structures during meiosis

Author(s): Tália Feijão, Bruno Marques, Rui D Silva, Célia Carvalho, Daniel Sobral, Ricardo Matos, Tian Tan, António Pereira, Eurico Morais-de-Sá, Hélder Maiato, Steven Z DeLuca, Rui Gonçalo Martinho
Published in: PNAS, 2022, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2204701119

Microtubule poleward flux in human cells is driven by the coordinated action of four kinesins

Author(s): Yulia Steblyanko, Girish Rajendraprasad, Mariana Osswald, Susana Eibes, Ariana Jacome, Stephan Geley, António J Pereira, Helder Maiato, Marin Barisic
Published in: EMBO J, 2020, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2020105432

Augmin-dependent microtubule self-organization drives kinetochore fiber maturation in mammals

Author(s): Ana C. Almeida, Joana Soares-de-Oliveira, Danica Drpic, Liam P. Cheeseman, Joana Damas, Harris, A. Lewin, Denis Larkin, Paulo Aguiar, António J. Pereira, Helder Maiato
Published in: Cell Reports, 2022, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2022.110610

α-Tubulin detyrosination impairs mitotic error correction by suppressing MCAK centromeric activity

Author(s): Luísa T. Ferreira, Bernardo Orr, Girish Rajendraprasad, António J. Pereira, Carolina Lemos, Joana T. Lima, Clàudia Guasch Boldú, Jorge G. Ferreira, Marin Barisic, Helder Maiato
Published in: Journal of Cell Biology, Issue 219/4, 2020, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.201910064

Optimized protocol for live-cell analysis of kinetochore fiber maturation in Indian muntjac cells

Author(s): Ana C. Almeida, Joana Soares-de-Oliveira, Helder Maiato
Published in: STAR Protocols, 2023, ISSN 2666-1667
Publisher: Elsevier
DOI: 10.1016/j.xpro.2022.102011

Double-checking chromosome segregation

Author(s): Helder Maiato; Sónia Silva
Published in: Journal of Cell Biology, Issue 1, 2023, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.202301106

Mechanisms of Chromosome Congression during Mitosis

Author(s): Helder Maiato, Ana Gomes, Filipe Sousa, Marin Barisic
Published in: Biology, Issue 6/4, 2017, Page(s) 13, ISSN 2079-7737
Publisher: MDPI AG
DOI: 10.3390/biology6010013

Cell Division: NuMA Bears the Load in the Spindle

Author(s): Helder Maiato, António J. Pereira
Published in: Current Biology, Issue 27/15, 2017, Page(s) R765-R767, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2017.06.060

Protein Phosphatase 1 inactivates Mps1 to ensure efficient Spindle Assembly Checkpoint silencing

Author(s): Margarida Moura, Mariana Osswald, Nelson Leça, João Barbosa, António J Pereira, Helder Maiato, Claudio E Sunkel, Carlos Conde
Published in: eLife, Issue 6, 2017, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/eLife.25366

Chromosome Segregation Is Biased by Kinetochore Size

Author(s): Danica Drpic, Ana C. Almeida, Paulo Aguiar, Fioranna Renda, Joana Damas, Harris A. Lewin, Denis M. Larkin, Alexey Khodjakov, Helder Maiato
Published in: Current Biology, 2018, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2018.03.023

Closing the tubulin detyrosination cycle

Author(s): Anna Akhmanova, Helder Maiato
Published in: Science, Issue 358/6369, 2017, Page(s) 1381-1382, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aar3895

Chromokinesins

Author(s): Ana C. Almeida, Helder Maiato
Published in: Current Biology, Issue 28/19, 2018, Page(s) R1131-R1135, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2018.07.017

Differential regulation of transition zone and centriole proteins contributes to ciliary base diversity

Author(s): Swadhin Chandra Jana, Susana Mendonça, Pedro Machado, Sascha Werner, Jaqueline Rocha, António Pereira, Helder Maiato, Mónica Bettencourt-Dias
Published in: Nature Cell Biology, Issue 20/8, 2018, Page(s) 928-941, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-018-0132-1

Actin divides to conquer

Author(s): Helder Maiato, Cristina Ferrás
Published in: Science, Issue 357/6353, 2017, Page(s) 756-757, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aao2461

A Regulatory Switch Alters Chromosome Motions at the Metaphase-to-Anaphase Transition

Author(s): Kuan-Chung Su, Zachary Barry, Nina Schweizer, Helder Maiato, Mark Bathe, Iain McPherson Cheeseman
Published in: Cell Reports, Issue 17/7, 2016, Page(s) 1728-1738, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2016.10.046

The Tubulin Code: A Navigation System for Chromosomes during Mitosis

Author(s): Marin Barisic, Helder Maiato
Published in: Trends in Cell Biology, Issue 26/10, 2016, Page(s) 766-775, ISSN 0962-8924
Publisher: Elsevier BV
DOI: 10.1016/j.tcb.2016.06.001

Mitotic progression, arrest, exit or death relies on centromere structural integrity, rather than de novo transcription

Author(s): Marco Novais-Cruz, Maria Alba Abad, Wilfred FJ van IJcken, Niels Galjart, A Arockia Jeyaprakash, Helder Maiato, Cristina Ferrás
Published in: eLife, Issue 7, 2018, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.36898

Kinetochore regulation: Let there be light

Author(s): Ana C Figueiredo, Helder Maiato
Published in: Nature Chemical Biology, Issue 13/10, 2017, Page(s) 1058-1059, ISSN 1552-4450
Publisher: Nature Publishing Group
DOI: 10.1038/nchembio.2464

No chromosome left behind: The importance of metaphase alignment for mitotic fidelity

Author(s): Bernardo Orr, Helder Maiato
Published in: The Journal of Cell Biology, 2019, Page(s) jcb.201902041, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.201902041

Coherent-hybrid STED: high contrast sub-diffraction imaging using a bi-vortex depletion beam

Author(s): António Pereira, Mafalda Sousa, Ana C. Almeida, Luísa T. Ferreira, Ana Rita Costa, Marco Novais-Cruz, Cristina Ferrás, Mónica Mendes Sousa, Paula Sampaio, Michael Belsley, Helder Maiato
Published in: Optics Express, Issue 27/6, 2019, Page(s) 8092, ISSN 1094-4087
Publisher: Optical Society of America
DOI: 10.1364/oe.27.008092

Spatiotemporal control of mitotic exit during anaphase by an aurora B-Cdk1 crosstalk

Author(s): Olga Afonso, Colleen M Castellani, Liam P Cheeseman, Jorge G Ferreira, Bernardo Orr, Luisa T Ferreira, James J Chambers, Eurico Morais-de-Sá, Thomas J Maresca, Helder Maiato
Published in: eLife, Issue 8, 2019, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.47646

CLASP2 binding to curved microtubule tips promotes flux and stabilizes kinetochore attachments

Author(s): Hugo Girão, Naoyuki Okada, Tony A. Rodrigues, Alexandra O. Silva, Ana C. Figueiredo, Zaira Garcia, Tatiana Moutinho-Santos, Ikuko Hayashi, Jorge E. Azevedo, Sandra Macedo-Ribeiro, Helder Maiato
Published in: The Journal of Cell Biology, 2019, Page(s) jcb.201905080, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.201905080

SOGA1 and SOGA2/MTCL1 are CLASP-interacting proteins required for faithful chromosome segregation in human cells

Author(s): Luisa T. Ferreira, Elsa Logarinho, Joana C. Macedo, Ana R. R. Maia, Helder Maiato.
Published in: Chromosome Research, 2021, ISSN 0967-3849
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10577-021-09651-8

Mitotic DNA damage promotes chromokinesin-mediated missegregation of polar chromosomes in cancer cells

Author(s): Marco Novais-Cruz, Antonio Pombinho, Mafalda Sousa, Andre F. Maia, Helder Maiato, Cristina Ferras
Published in: Molecular Biology of the Cell, Issue 5, 2023, ISSN 1059-1524
Publisher: American Society for Cell Biology
DOI: 10.1091/mbc.e22-11-0518

Centrosome-nuclear axis repositioning drives the assembly of a bipolar spindle scaffold to ensure mitotic fidelity

Author(s): Vanessa Nunes, Margarida Dantas, Domingos Castro, Elisa Vitiello, Irène Wang, Nicolas Carpi, Martial Balland, Matthieu Piel, Paulo Aguiar, Helder Maiato, Jorge G. Ferreira
Published in: Molecular Biology of the Cell, 2020, ISSN 1059-1524
Publisher: American Society for Cell Biology
DOI: 10.1091/mbc.e20-01-0047

Dissecting the role of the tubulin code in mitosis

Author(s): Luísa T. Ferreira, Ana C. Figueiredo, Bernardo Orr, Danilo Lopes, Helder Maiato
Published in: Mitosis and Meiosis Part A, Issue 144, 2018, Page(s) 33-74, ISBN 9780-128141441
Publisher: Elsevier
DOI: 10.1016/bs.mcb.2018.03.040

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